PH-sensitive bionanocomposite hydrogel beads based on carboxymethyl cellulose/ZnO nanoparticle as drug carrier

2016 ◽  
Vol 93 ◽  
pp. 1317-1327 ◽  
Author(s):  
Zhila Zare-Akbari ◽  
Hassan Farhadnejad ◽  
Behrouz Furughi-Nia ◽  
Saeedeh Abedin ◽  
Mehdi Yadollahi ◽  
...  
Keyword(s):  
Carboxymethyl Cellulose ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Zno Nanoparticle ◽  
Hydrogel Beads

scholarly journals Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

2018 ◽  
Vol 7 (4) ◽  
pp. 291-301 ◽  
Author(s):  
Zepeng Jiao ◽  
Bin Zhang ◽  
Chunya Li ◽  
Weicong Kuang ◽  
Jingxian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Tumor Growth Inhibition

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

Synthesis and characterization of an amphiphilic graft polymer and its potential as a pH-sensitive drug carrier

Polymer ◽  
2011 ◽  
Vol 52 (15) ◽  
pp. 3304-3310 ◽  
Author(s):  
Yi Li ◽  
Hye Jung Heo ◽  
Guang Hui Gao ◽  
Seong Woo Kang ◽  
Cong Truc Huynh ◽  
...  
Keyword(s):  
Drug Carrier ◽  
Ph Sensitive ◽  
Synthesis And Characterization ◽  
Graft Polymer
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