scholarly journals Decreasing in-hospital mortality rate in severe sepsis and septic shock patients by implementing a sepsis bundle in University Hospital, Trnava

2014 ◽  
Vol 21 ◽  
pp. 409
Author(s):  
Z. Skvarkova ◽  
J. Brnova ◽  
A. Streharova ◽  
A. Simkova ◽  
L. Michalikova ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Mortality Rate ◽  
Hospital Mortality ◽  
University Hospital ◽  
Sepsis And Septic Shock ◽  
Sepsis Bundle

The epidemiology of, and risk factors for, mortality from severe sepsis and septic shock in a tertiary-care university hospital setting

2009 ◽  
Vol 137 (9) ◽  
pp. 1333-1341 ◽  
Author(s):  
B. KHWANNIMIT ◽  
R. BHURAYANONTACHAI
Keyword(s):  
Risk Factors ◽  
Septic Shock ◽  
Severe Sepsis ◽  
Hospital Mortality ◽  
Tertiary Care ◽  
Hospital Setting ◽  
University Hospital ◽  
Apache Ii Score ◽  
Sepsis And Septic Shock ◽  
Hospital Acquired

SUMMARYThis study investigated the clinical characteristics of, and outcomes and risk factors for hospital mortality of 390 patients admitted with severe sepsis or septic shock in an intensive care unit (ICU). Prospectively collected data from patients collected between 1 July 2004 and 30 June 2006 were analysed. Overall hospital mortality was 49·7% and comorbidities were found in 40·3% of patients, the most common of which was haematological malignancy. The respiratory tract was the most common site of infection (50%). Hospital-acquired infections accounted for 55·6% of patients with Gram-negative bacteria predominant (68%). Multivariate analysis showed that acute respiratory distress syndrome, pulmonary artery catheter placement, comorbidities, hospital-acquired infection, APACHE II score and maximum LOD score, were independent risk factors for hospital mortality. In conclusion, severe sepsis and septic shock are common causes of ICU admission. Patients with risk factors for increased mortality should be carefully monitored and aggressive treatment administered.

Multicenter Implementation Of Sepsis Bundle And Decreased Mortality In Severe Sepsis And Septic Shock Patients

2012 ◽  
Author(s):  
Russell R. Miller ◽  
Li Dong ◽  
Nancy C. Nelson ◽  
Daniel R. Probst ◽  
Kathryn G. Kuttler ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Sepsis And Septic Shock ◽  
Sepsis Bundle

scholarly journals Decreasing Mortality in Severe Sepsis and Septic Shock Patients by Implementing a Sepsis Bundle in a Hospital Setting

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e26790 ◽  
Author(s):  
Sandra Christina Pereira Lima Shiramizo ◽  
Alexandre R. Marra ◽  
Marcelino S. Durão ◽  
Ângela T. Paes ◽  
Michael B. Edmond ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Hospital Setting ◽  
Sepsis And Septic Shock ◽  
Sepsis Bundle

scholarly journals Adequate antibiotic therapy prior to ICU admission in patients with severe sepsis and septic shock reduces hospital mortality

Critical Care ◽  
2015 ◽  
Vol 19 (1) ◽  
Author(s):  
José Garnacho-Montero ◽  
Antonio Gutiérrez-Pizarraya ◽  
Ana Escoresca-Ortega ◽  
Esperanza Fernández-Delgado ◽  
José María López-Sánchez
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Hospital Mortality ◽  
Antibiotic Therapy ◽  
Icu Admission ◽  
Sepsis And Septic Shock

Impact of New-Onset Left Ventricular Dysfunction on Outcomes in Mechanically Ventilated Patients With Severe Sepsis and Septic Shock

2016 ◽  
Vol 33 (12) ◽  
pp. 680-686 ◽  
Author(s):  
Saraschandra Vallabhajosyula ◽  
Shane M. Gillespie ◽  
David W. Barbara ◽  
Nandan S. Anavekar ◽  
Juan N. Pulido
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Hospital Mortality ◽  
Diastolic Dysfunction ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Systolic Dysfunction ◽  
Secondary Outcomes ◽  
Sepsis And Septic Shock

Background: Left ventricular systolic dysfunction (LVSD) and LV diastolic dysfunction (LVDD) are commonly seen in severe sepsis and septic shock; however, their role in patients with concurrent invasive mechanical ventilation (IMV) is less well defined. Methods: This was a prospective observational study on all patients admitted to all the intensive care units (ICUs) at Mayo Clinic, Rochester from August 2007 to January 2009. All adult patients with severe sepsis and septic shock and concurrent IMV without prior heart failure underwent transthoracic echocardiography within 24 hours. Patients with active pregnancy, prior congenital or valvular heart disease, and prosthetic cardiac valves were excluded. Left ventricular systolic dysfunction was defined as LV ejection fraction (LVEF) <50% and LVDD as E/e′ >15. Primary outcome was hospital mortality, and secondary outcomes included IMV duration, ICU length of stay (LOS), and total LOS. Two-tailed P value of <.05 was considered statistically significant. Results: In a total of 106 patients, 58 (54.7%) met our inclusion criteria, with 17 (29.3%), 11 (19.0%), and 5 (8.6%) having LVSD, LVDD, and both, respectively. The cohorts with and without LVSD and LVDD did not differ significantly in their baseline characteristics and laboratory and ventilatory parameters. Compared to those without LVSD, patients with LVSD had higher LV end-systolic diameters but were not different in their left atrial diameters or E/e′ ratio. Patients with LVDD had a higher E velocity and E/e′ ratio compared to those without LVDD. Hospital mortality was not different in patients with and without LVSD (8 [47%] vs 21 [51%], P = 1.00) and LVDD (8 [73%] vs 21 [45%], P = .18). Secondary outcomes were not different between the 2 groups. Conclusion: Left ventricular systolic or diastolic dysfunction did not influence in-hospital outcomes in patients with severe sepsis and septic shock and concurrent IMV.

scholarly journals Cell-Free Plasma DNA as a Predictor of Outcome in Severe Sepsis and Septic Shock

2008 ◽  
Vol 54 (6) ◽  
pp. 1000-1007 ◽  
Author(s):  
Katri Saukkonen ◽  
Päivi Lakkisto ◽  
Ville Pettilä ◽  
Marjut Varpula ◽  
Sari Karlsson ◽  
...  
Keyword(s):  
Septic Shock ◽  
Regression Analysis ◽  
Severe Sepsis ◽  
Hospital Mortality ◽  
Independent Predictor ◽  
Discriminative Power ◽  
Plasma Dna ◽  
Icu Mortality ◽  
Sepsis And Septic Shock ◽  
Free Plasma

Abstract Background: Increased concentrations of cell-free DNA have been found in plasma of septic and critically ill patients. We investigated the value of plasma DNA for the prediction of intensive care unit (ICU) and hospital mortality and its association with the degree of organ dysfunction and disease severity in patients with severe sepsis. Methods: We studied 255 patients with severe sepsis or septic shock. We obtained blood samples on the day of study inclusion and 72 h later and measured cell-free plasma DNA by real-time quantitative PCR assay for the β-globin gene. Results: Cell-free plasma DNA concentrations were higher at admission in ICU nonsurvivors than in survivors (median 15 904 vs 7522 genome equivalents [GE]/mL, P &lt; 0.001) and 72 h later (median 15 176 GE/mL vs 6758 GE/mL, P = 0.004). Plasma DNA values were also higher in hospital nonsurvivors than in survivors (P = 0.008 to 0.009). By ROC analysis, plasma DNA concentrations had moderate discriminative power for ICU mortality (AUC 0.70–0.71). In multiple regression analysis, first-day plasma DNA was an independent predictor for ICU mortality (P = 0.005) but not for hospital mortality. Maximum lactate value and Sequential Organ Failure Assessment score correlated independently with the first-day plasma DNA in linear regression analysis. Conclusions: Cell-free plasma DNA concentrations were significantly higher in ICU and hospital nonsurvivors than in survivors and showed a moderate discriminative power regarding ICU mortality. Plasma DNA concentration was an independent predictor for ICU mortality, but not for hospital mortality, a finding that decreases its clinical value in severe sepsis and septic shock.

IN HOSPITAL MORTALITY BENEFIT WITH COMBINED LOW DOSE VITAMIN C AND HYDROCORTISONE IN SEVERE SEPSIS AND SEPTIC SHOCK

CHEST Journal ◽  
2019 ◽  
Vol 156 (4) ◽  
pp. A1645-A1646
Author(s):  
Elyana Matayeva ◽  
Theresa Henson ◽  
Nashreen Anderson ◽  
Donald Brown ◽  
Raghavendra Sanivarapu ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Vitamin C ◽  
Hospital Mortality ◽  
Low Dose ◽  
Mortality Benefit ◽  
Sepsis And Septic Shock
Sign in / Sign up

Export Citation Format

Share Document