Expression of vascular endothelial growth factor and its receptors after mandibular distraction osteogenesis

2007 ◽  
Vol 36 (4) ◽  
pp. 338-344 ◽  
Author(s):  
J.-H. Byun ◽  
B.-W. Park ◽  
J.-R. Kim ◽  
J.-H. Lee
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Distraction Osteogenesis ◽  
Vascular Endothelial ◽  
Mandibular Distraction ◽  
Mandibular Distraction Osteogenesis ◽  
Endothelial Growth Factor

High-purity magnesium pin enhances bone consolidation in distraction osteogenesis model through activation of the VHL/HIF-1α/VEGF signaling

2020 ◽  
Vol 35 (2) ◽  
pp. 224-236
Author(s):  
Musha Hamushan ◽  
Weijie Cai ◽  
Yubo Zhang ◽  
Tengfei Lou ◽  
Shaoxiang Zhang ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Distraction Osteogenesis ◽  
High Purity ◽  
Hypoxia Inducible Factor ◽  
Vascular Endothelial ◽  
Von Hippel Lindau ◽  
Hypoxia Inducible Factor 1Α ◽  
Bone Consolidation ◽  
Endothelial Growth Factor

Distraction osteogenesis has widespread clinical use in the treatment of large bone defects. Nonetheless, the prolonged consolidation period carries the risk of complications. Magnesium-based materials have been shown to promote bone regeneration in fracture healing both in vitro and in vivo. Here, we investigated whether high-purity magnesium could enhance bone formation in distraction osteogenesis. High-purity magnesium pins were placed into the medullary cavity in the rat distraction osteogenesis model. Results showed that the bone volume/total tissue volume, bone mineral density, and mechanical properties of new callus were significantly higher in the high-purity magnesium group compared to stainless steel and control group (p < 0.01). Histological analyses confirmed improved bone consolidation and vascularization in high-purity magnesium group. Further, polymerase chain reaction-array investigation, Western blot, and immunohistochemical results found that vascular endothelial growth factor and hypoxia inducible factor-1α were highly expressed in the high-purity magnesium group, while Von Hippel–Lindau protein was the opposite (p < 0.01). In conclusion, high-purity magnesium implants have the potential to enhance angiogenesis and bone consolidation in the distraction osteogenesis application, and this process might be via the regulation of Von Hippel–Lindau/hypoxia inducible factor-1α/vascular endothelial growth factor signaling.

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