Platelet rich fibrin-a promising approach for tissue regeneration in oral and maxillofacial surgery: preclinical and clinical studies

2015 ◽  
Vol 44 ◽  
pp. e67
Author(s):  
S. Ghanaati ◽  
A. Kubesch ◽  
J. Lorenz ◽  
M. Barbeck ◽  
A. Teiler ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Clinical Studies ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Platelet Rich Fibrin ◽  
Preclinical And Clinical Studies

scholarly journals Application of 3-D Printing for Tissue Regeneration in Oral and Maxillofacial Surgery: What is Upcoming?

2018 ◽  
Author(s):  
Seied Omid Keyhan ◽  
Hamidreza Fallahi ◽  
Alireza Jahangirnia ◽  
Mohammad Taher Amirzade-Iranaq ◽  
Mohammad Hosein Amirzade-Iranaq
Keyword(s):  
Tissue Regeneration ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery

Use of Platelet-Rich Plasma and Platelet-Rich Fibrin in Dentistry and Oral Surgery: Introduction and Review of the Literature

2019 ◽  
Vol 36 (2) ◽  
pp. 109-123 ◽  
Author(s):  
Kristina Feigin ◽  
Bonnie Shope
Keyword(s):  
Soft Tissues ◽  
Oral Surgery ◽  
Platelet Rich Plasma ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Platelet Concentrates ◽  
Platelet Rich Fibrin ◽  
Wide Range ◽  
Comprehensive Examination ◽  
And Function

Platelet concentrates, mostly represented by platelet-rich plasma and platelet-rich fibrin, have gained significant interest in various medical and oral disciplines because of their potential to stimulate and boost regeneration of hard and soft tissues. Prepared from the patient’s own blood, they have been tested and used in various different surgical fields including oral and maxillofacial surgery. The effects of these biomaterials are described to be a result of the large concentration of platelets which contain a wide range of growth factors. The aim of this article is to introduce the principle and function of these platelet concentrates, to review their preparation, and to provide a comprehensive examination of the published oral and maxillofacial literature on this subject.

scholarly journals The 3 R’s for Platelet-Rich Fibrin: A “Super” Tri-Dimensional Biomaterial for Contemporary Naturally-Guided Oro-Maxillo-Facial Soft and Hard Tissue Repair, Reconstruction and Regeneration

Materials ◽  
2018 ◽  
Vol 11 (8) ◽  
pp. 1293 ◽  
Author(s):  
Consuelo Zumarán ◽  
Marcelo Parra ◽  
Sergio Olate ◽  
Eduardo Fernández ◽  
Francisco Muñoz ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Oral Surgery ◽  
Therapeutic Potential ◽  
Maxillofacial Surgery ◽  
Clinical Effectiveness ◽  
Oral And Maxillofacial Surgery ◽  
User Friendliness ◽  
Platelet Rich Fibrin ◽  
Tissue Repair And Regeneration ◽  
Regenerative Dentistry

Platelet-Rich fibrin (PRF) is a three-dimensional (3-D) autogenous biomaterial obtained via simple and rapid centrifugation from the patient’s whole blood samples, without including anti-coagulants, bovine thrombin, additives, or any gelifying agents. At the moment, it is safe to say that in oral and maxillofacial surgery, PRFs (particularly, the pure platelet-rich fibrin or P-PRF and leukocyte and platelet-rich fibrin or L-PRF sub-families) are receiving the most attention, essentially because of their simplicity, cost-effectiveness, and user-friendliness/malleability; they are a fairly new “revolutionary” step in second-generation therapies based on platelet concentration, indeed. Yet, the clinical effectiveness of such surgical adjuvants or regenerative platelet concentrate-based preparations continues to be highly debatable, primarily as a result of preparation protocol variability, limited evidence-based clinical literature, and/or poor understanding of bio-components and clinico-mechanical properties. To provide a practical update on the application of PRFs during oral surgery procedures, this critical review focuses on evidence obtained from human randomized and controlled clinical trials only. The aim is to serve the reader with current information on the clinical potential, limitations, challenges, and prospects of PRFs. Accordingly, reports often associate autologous PRFs with early bone formation and maturation; accelerated soft-tissue healing; and reduced post-surgical edema, pain, and discomfort. An advanced and original tool in regenerative dentistry, PRFs present a strong alternative and presumably cost-effective biomaterial for oro-maxillo-facial tissue (soft and hard) repair and regeneration. Yet, preparation protocols continue to be a source of confusion, thereby requiring revision and standardization. Moreover, to increase the validity, comprehension, and therapeutic potential of the reported findings or observations, a decent analysis of the mechanico-rheological properties, bio-components, and their bioactive function is eagerly needed and awaited; afterwards, the field can progress toward a brand-new era of “super” oro-dental biomaterials and bioscaffolds for use in oral and maxillofacial tissue repair and regeneration, and beyond.

COMPARISON OF POST EXTRACTION SOCKET HEALING WITH AND WITHOUT USING PLATELET RICH FIBRIN (PRF) – A CLINICAL AND RADIOGRAPHIC STUDY

2021 ◽  
pp. 62-65
Author(s):  
S.P. Indra Kumar ◽  
Kavin T ◽  
Narendar R ◽  
E. Gayathri Priyadharshini ◽  
Akshaya murugan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Maxillofacial Surgery ◽  
Test Group ◽  
Control Group ◽  
Oral And Maxillofacial Surgery ◽  
Soft Tissue Healing ◽  
Extraction Socket ◽  
Platelet Rich Fibrin ◽  
Tissue Healing ◽  
Socket Healing

AIM: The aim of this study is to comparatively evaluate the post extraction socket healing clinically and radiographically with and without using Platelet Rich Fibrin (PRF). MATERIALS AND METHODS: Fifty, otherwise healthy individuals undergoing dental treatment in the department of Oral and Maxillofacial surgery, Vivekananda Dental College for women, Thiruchengode, were randomly selected and the participants were divided into two groups – test group(PRF, n=25) and control group (Blood clot, n=25). Blood was freshly obtained from the participants of the test group and PRF was prepared. PRF was placed in the sockets of the test group and followed by the pressure application and suturing. Control group were allowed to heal naturally. Clinically, soft tissue healing and socket closure were assessed. Radiographic analysis of socket healing done by comparison of pre- and post-operative radiographs. The clinical follow-up assessments were done at an interval of 3 days, 1 week and 4 weeks and the data obtained were assessed. The patients were aged above 18 years, i RESULT: ncluding 33 females and 17 males. The soft tissue and socket healing were higher in the test group when compared with the control group clinically and the mean proportion of radiographic bone ll was signicantly higher in the test group in all the time intervals of 3 days, 1 week and 4 weeks, respectively. Outcome of the study CONCLUSION: demonstrate that the PRF placement in the extraction socket accelerates soft tissue healing and socket healing and increases the bone ll and reduces the bone resorption using clinical and radiographic methods.

scholarly journals Mitochondrial Bioenergetic, Photobiomodulation and Trigeminal Branches Nerve Damage, What’s the Connection? A Review

2021 ◽  
Vol 22 (9) ◽  
pp. 4347
Author(s):  
Silvia Ravera ◽  
Esteban Colombo ◽  
Claudio Pasquale ◽  
Stefano Benedicenti ◽  
Luca Solimei ◽  
...  
Keyword(s):  
Trigeminal Nerve ◽  
Maxillofacial Surgery ◽  
Bound Water ◽  
Cell Manipulation ◽  
Oral And Maxillofacial Surgery ◽  
Nir Light ◽  
Interesting Candidate ◽  
Nerve Recovery ◽  
Preclinical And Clinical Studies ◽  
Energetic Variation

Background: Injury of the trigeminal nerve in oral and maxillofacial surgery can occur. Schwann cell mitochondria are regulators in the development, maintenance and regeneration of peripheral nerve axons. Evidence shows that after the nerve injury, mitochondrial bioenergetic dysfunction occurs and is associated with pain, neuropathy and nerve regeneration deficit. A challenge for research is to individuate new therapies able to normalise mitochondrial and energetic metabolism to aid nerve recovery after damage. Photobiomodulation therapy can be an interesting candidate, because it is a technique involving cell manipulation through the photonic energy of a non-ionising light source (visible and NIR light), which produces a nonthermal therapeutic effect on the stressed tissue. Methods: The review was based on the following questions: (1) Can photo-biomodulation by red and NIR light affect mitochondrial bioenergetics? (2) Can photobiomodulation support damage to the trigeminal nerve branches? (preclinical and clinical studies), and, if yes, (3) What is the best photobiomodulatory therapy for the recovery of the trigeminal nerve branches? The papers were searched using the PubMed, Scopus and Cochrane databases. This review followed the ARRIVE-2.0, PRISMA and Cochrane RoB-2 guidelines. Results and conclusions: The reliability of photobiomodulatory event strongly bases on biological and physical-chemical evidence. Its principal player is the mitochondrion, whether its cytochromes are directly involved as a photoacceptor or indirectly through a vibrational and energetic variation of bound water: water as the photoacceptor. The 808-nm and 100 J/cm2 (0.07 W; 2.5 W/cm2; pulsed 50 Hz; 27 J per point; 80 s) on rats and 800-nm and 0.2 W/cm2 (0.2 W; 12 J/cm2; 12 J per point; 60 s, CW) on humans resulted as trustworthy therapies, which could be supported by extensive studies.

scholarly journals USE OF PLATELET-RICH FIBRIN IN MAXILLOFACIAL SURGERY

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Nenad Tanasković
Keyword(s):  
Soft Tissue ◽  
Second Generation ◽  
Maxillofacial Surgery ◽  
Biological Properties ◽  
Platelet Concentrate ◽  
Oral And Maxillofacial Surgery ◽  
Platelet Rich Fibrin ◽  
Ridge Augmentation ◽  
Wide Range ◽  
Autologous Platelet Concentrate

Platelet Rich Fibrin (PRF) is autologous biomaterial which is the second-generation platelet concentrate. It has a favorable biological properties that accelerate healing of soft tissue, and bone, giveing a wide range of applications found in oral and maxillofacial surgery and other surgical fields. PRF technique was developed by Choukroun et al in 2001 and it represents a second generation of autologous platelet concentrate, which is used to accelerate the healing of soft and hard tissue. In contrast to the PRP, the PRF is composed of autologous fibrin matrix in which a large amount of platelets and their growth factors are embedded. PRF-graft is used in augmentative techniques residual bone defects, alone or in combination with biomaterials. When the alveolar ridge augmentation technique GBR, the PRF membranes can be used for protection and stabilization of bone compensation. PRF accelerates the healing of soft tissue and reduces the possibility of dehiscence and exposure of the membrane.

scholarly journals From Platelet-Rich Plasma to Advanced Platelet-Rich Fibrin: Biological Achievements and Clinical Advances in Modern Surgery

2019 ◽  
Vol 13 (02) ◽  
pp. 280-286 ◽  
Author(s):  
Andrea Caruana ◽  
Daniele Savina ◽  
José Paulo Macedo ◽  
Sandra Clara Soares
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Tissue Regeneration ◽  
Second Generation ◽  
Transforming Growth Factor ◽  
Platelet Rich Plasma ◽  
Maxillofacial Surgery ◽  
Cellular Migration ◽  
Platelet Concentrates ◽  
Platelet Rich Fibrin

AbstractIn the past 20 years, the platelet concentrates have evolved from first-generation products, i.e., platelet-rich plasma (PRP) and plasma rich in growth factors to the second-generation products such as leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF). These autologous products with a higher leukocyte inclusion and flexible fibrin mesh act as a scaffold to increase cellular migration in the angiogenic, osteogenic, and antimicrobial potential of these biomaterials in tissue regeneration. In the second-generation platelet concentrates, the protocols are easier, cheaper, and faster with an entire physiological fibrin matrix, resulting in a tridimensional mesh, not as rigid as one of the first generations. This allows the slow release of molecules over a longer period of time and triggers the healing and regenerative process at the site of injury. The potential of A-PRF to mimic the physiology and immunology of wound healing is also due to the high concentration of growth factors released as follows: vascular endothelial growth factor, platelet-derived growth factor, transforming growth factor-β, and anti-inflammatory cytokines that stimulate tissue cicatrization, vessels formation, and bone cell proliferation and differentiation. Furthermore, the number of neutrophils and monocytes/macrophages is higher releasing important chemotactic molecules such as chemokine ligand-5 and eotaxin. Thus, L-PRF and A-PRF have been used, especially in implantology, periodontology, and maxillofacial surgery. Future clinical applications include tissue regeneration/grafts, ulcers/skin necrosis in the diabetic patient and others, plastic surgery, and even musculoskeletal lesions.

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