A microdialysis model to examine nasal drug delivery and olfactory absorption in rats using lidocaine hydrochloride as a model drug

2004 ◽  
Vol 269 (2) ◽  
pp. 311-322 ◽  
Author(s):  
Morten Bagger ◽  
Erik Bechgaard
Keyword(s):  
Drug Delivery ◽  
Lidocaine Hydrochloride ◽  
Nasal Drug Delivery ◽  
Model Drug

Real-time quantitative monitoring of in vitro nasal drug delivery by a nasal epithelial mucosa-on-a-chip model

2021 ◽  
Author(s):  
Hanieh Gholizadeh ◽  
Hui Xin Ong ◽  
Peta Bradbury ◽  
Agisilaos Kourmatzis ◽  
Daniela Traini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Nasal Drug Delivery ◽  
Quantitative Monitoring

scholarly journals Effect of Poly(L-lysine) and Heparin Coatings on the Surface of Polyester-Based Particles on Prednisolone Release and Biocompatibility

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 801
Author(s):  
Abdelrahman Mohamed ◽  
Viktor Korzhikov-Vlakh ◽  
Nan Zhang ◽  
André Said ◽  
Iuliia Pilipenko ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Molecular Diffusion ◽  
Corneal Opacity ◽  
Testing Strategy ◽  
Release Process ◽  
Irritation Test ◽  
Model Drug ◽  
Novel Drug ◽  
Permeability Assay

A plethora of micro- and nanoparticle types are currently investigated for advanced ocular treatment due to improved drug retention times, higher bioavailability and better biocompatibility. Yet, comparative studies of both physicochemical and toxicological performance of these novel drug delivery systems are still rare. Herein, poly(L-lactic acid)- and poly(ε-caprolactone)-based micro- and nanoparticles were loaded with prednisolone as a model drug. The physicochemical properties of the particles were varied with respect to their hydrophilicity and size as well as their charge and the effect on prednisolone release was evaluated. The particle biocompatibility was assessed by a two-tier testing strategy, combining the EpiOcularTM eye irritation test and bovine corneal opacity and permeability assay. The biodegradable polyelectrolyte corona on the particles’ surface determined the surface charge and the release rate, enabling prednisolone release for at least 30 days. Thereby, the prednisolone release process was mainly governed by molecular diffusion. Finally, the developed particle formulations were found to be nontoxic in the tested range of concentrations.

Fundamentals in nasal drug delivery

2019 ◽  
pp. 343-360
Author(s):  
Zachary Warnken ◽  
Yu Jin Kim ◽  
Heidi M. Mansour ◽  
Robert O. Williams ◽  
Hugh D.C. Smyth
Keyword(s):  
Drug Delivery ◽  
Nasal Drug Delivery
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