Immunohistochemical analysis of retraction pocket pars tensa of tympanic membrane in children

2019 ◽  
Vol 122 ◽  
pp. 111-116
Author(s):  
Milan Urík ◽  
Pavel Hurník ◽  
Dušan Žiak ◽  
Josef Machač ◽  
Ivo Šlapák ◽  
...  
Keyword(s):  
Tympanic Membrane ◽  
Immunohistochemical Analysis ◽  
Retraction Pocket ◽  
Pars Tensa

scholarly journals Pathogenesis of Retraction Pocket of the Tympanic Membrane—A Narrative Review

Medicina ◽  
2021 ◽  
Vol 57 (5) ◽  
pp. 425
Author(s):  
Milan Urík ◽  
Miroslav Tedla ◽  
Pavel Hurník
Keyword(s):  
Tympanic Membrane ◽  
Middle Ear ◽  
Immunohistochemical Study ◽  
Current Knowledge ◽  
Immunohistochemical Analysis ◽  
Narrative Review ◽  
Retraction Pocket ◽  
Middle Ear Pressure ◽  
A Current

Several theories describe the development of the retraction pocket of the tympanic membrane (RP). Many authors suggest that the negative middle ear pressure is the main reason responsible for developing this condition. A narrative review has been undertaken, and conclusions are drawn reflecting a current knowledge with our new observations in the histological and immunohistochemical study. Recent studies show the important role of inflammation in the development and progression of RP. A review of the available literature shows that the inflammation plays a key role in pathogenesis of the RP and its progression to the cholesteatoma. We support this statement with our new results from histological and immunohistochemical analysis of the RPs.

Histological analysis of retraction pocket pars tensa of tympanic membrane in children

2016 ◽  
Vol 86 ◽  
pp. 213-217 ◽  
Author(s):  
M. Urík ◽  
P. Hurník ◽  
D. Žiak ◽  
J. Machač ◽  
I. Šlapák ◽  
...  
Keyword(s):  
Tympanic Membrane ◽  
Histological Analysis ◽  
Retraction Pocket ◽  
Pars Tensa

Tympanic membrane atelectasis in childhood otitis media with effusion

1995 ◽  
Vol 109 (6) ◽  
pp. 495-498 ◽  
Author(s):  
H. L. Tay ◽  
R. P. Mills
Keyword(s):  
Multivariate Analysis ◽  
Tympanic Membrane ◽  
Otitis Media With Effusion ◽  
Pars Tensa ◽  
Hearing Thresholds ◽  
Inferior Segment ◽  
Glue Ear ◽  
The Difference ◽  
A Prospective Study ◽  
Relevant Factors

AbstractA prospective study on the dynamics of tympanic membrane atelectasis during the treatment for glue ear was performed in a sample of 115 ears of 83 children aged between one and 11 years. The progression in the degree of pars tensa atelectasis was analysed in relation to six potentially relevant factors. Multivariate analysis showed that the factor with the most predictive value on the progression of the pars tensa retraction was the grade of atelectasis at initial detection (p<0.0001). The use of grommets did not have any significant influence on the outcome grade of atelectasis. There was an association between previous grommet insertion and localized retractions in the inferior segment of the pars tensa (P<0.0001). However, localized retractions in the postero-superior quadrant were not associated with previous grommet insertion (P<0.02). Although the hearing thresholds of atelectatic ears were significantly worse than normal ears especially at 4 kHz (p<0.006), the difference was less than 5 dB.

Management of retraction pockets of the pars tensa

1991 ◽  
Vol 105 (7) ◽  
pp. 525-528 ◽  
Author(s):  
Robert P. Mills
Keyword(s):  
Surgical Treatment ◽  
Tympanic Membrane ◽  
Composite Graft ◽  
Study Group ◽  
Pars Tensa ◽  
Retraction Pockets

AbstractA study of 73 patients with retraction pockets of the pars tensa (93 affected ears) has been carried out. Of these 32 per cent had otalgia and 31 per cent reported episodes of aural discharge. Adequate audiometric data was available on 75 ears. Mean air-bone gaps were calculated using 500 Hz, 1000 Hz, 2000 Hz and 4000 Hz. Thirty per cent of ears had air-bone gaps of less than 10 dB and in 93 per cent the air-bone gap was less than 30 dB. Air-bone gaps of more than 40 dB were found in seven per cent. Of this group, seven patients were selected for surgical treatment. In all cases the retraction pockets were elevated and everted. In six cases, the thinned tympanic membrane was reinforced with a composite graft of cartilage and perichondrium. This technique has also been used in three patients not included in this study group. An ossiculoplasty was performed in four cases. In the early months, the retraction pockets remained completely everted. However, by 12 months some degree of retraction had recurred in four of the six patients who have been followed for more than 12 months.

Experimental Retraction Pocket Cholesteatoma

1986 ◽  
Vol 95 (6) ◽  
pp. 639-644 ◽  
Author(s):  
David E. Wolfman ◽  
Richard A. Chole
Keyword(s):  
Animal Model ◽  
Experimental Evidence ◽  
Tympanic Membrane ◽  
Eustachian Tube ◽  
Middle Ear ◽  
Mongolian Gerbils ◽  
Retraction Pocket ◽  
Tube Obstruction ◽  
Middle Ear Fluid ◽  
Acquired Cholesteatoma

An animal model for retraction pocket (primary acquired) cholesteatoma is presented. Bilateral eustachian tube obstruction by electrocauterization of the nasopharyngeal portion was performed in 16 Mongolian gerbils. Animals were killed at 2, 4, 8, and 16 weeks. At 2 weeks all animals had bilateral serous effusions and retracted tympanic membranes. At 4 weeks, four of eight ears had middle ear fluid, retractions, and cholesteatomas. After 8 weeks, five of eight ears had middle ear effusions, and four of these had cholesteatomas; one ear had total atelectasis with a cholesteatoma filling the bulla. By 16 weeks, six of eight ears had developed cholesteatomas. Some animals did not develop effusion or retraction because of failure or recanalization of eustachian tube obstruction. This study provides experimental evidence that aural cholesteatomas may arise by retraction of the tympanic membrane.

Epithelial migration in the atelectatic tympanic membrane

2009 ◽  
Vol 123 (12) ◽  
pp. 1321-1324 ◽  
Author(s):  
I P Tang ◽  
N Prepageran ◽  
R Raman ◽  
T Sharizhal
Keyword(s):  
Methylene Blue ◽  
Tympanic Membrane ◽  
Migration Rate ◽  
Blue Staining ◽  
Blue Dye ◽  
Retraction Pocket ◽  
Epithelial Migration ◽  
Significant Difference ◽  
And Control ◽  
Tympanic Membranes

AbstractObjective:To determine whether epithelial migration in the atelectatic tympanic membrane (secondary to any pathology) occurs in a similar fashion to that in the normal (non-pathological) tympanic membrane, by calculating and comparing the epithelial migration rate and pattern.Study design:Prospective, non-randomised, case–control study. This study was a pilot study. We included patients with an atelectatic pars tensa region of the tympanic membrane and a healthy contralateral tympanic membrane (the latter used as the control).Setting:Otorhinolaryngology out-patient clinic. The study was conducted from January 2006 to January 2008.Intervention:A total of 40 patients (80 ears) were included based on their otoscopic appearance and tympanography findings. All patients' ears were examined under an operating microscope. A dot of methylene blue dye was applied in the immediate vicinity of the umbo of the atelectatic tympanic membrane, and in the same position on the tympanic membrane of the control ear. Patients were then followed up weekly until the dye dot had migrated to reach the annulus.Main outcome measures:Direction and rate of epithelial migration.Results:In the atelectatic tympanic membranes, epithelial migration proceeded from the centre of the retraction pocket toward the annulus in a lateral, radiating manner. Thirty-three (82.5 per cent) of the 40 patients showed a similar migratory pattern in both the study and control ears. Sixty per cent of the retracted tympanic membranes showed no migration in the first week after methylene blue staining. After the first week, the migration rate was nearly constant from the umbo towards the periphery, in both the study and control ears. The mean daily epithelial migration rate in the study and control ears was 62.6 and 64.7 µm/day, respectively; however, this difference was statistically insignificant (p = 0.202, independent samplest-test).Conclusion:There is no difference in the epithelial migration rate or pattern, comparing atelectatic tympanic membranes and normal tympanic membranes. However, there may be a significant difference in the epithelial migration rate with increased grades of tympanic membrane atelectasis.

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