Outcomes of visual acuity in carbon ion radiotherapy: Analysis of dose–volume histograms and prognostic factors

2006 ◽  
Vol 64 (2) ◽  
pp. 396-401 ◽  
Author(s):  
Azusa Hasegawa ◽  
Jun-etsu Mizoe ◽  
Atsushi Mizota ◽  
Hirohiko Tsujii
Keyword(s):  
Visual Acuity ◽  
Prognostic Factors ◽  
Carbon Ion Radiotherapy ◽  
Carbon Ion ◽  
Dose Volume Histograms ◽  
Dose Volume

scholarly journals Radiomics and Dosiomics for Predicting Local Control after Carbon-Ion Radiotherapy in Skull-Base Chordoma

Cancers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 339
Author(s):  
Giulia Buizza ◽  
Chiara Paganelli ◽  
Emma D’Ippolito ◽  
Giulia Fontana ◽  
Silvia Molinelli ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Skull Base ◽  
Local Control ◽  
Tumour Progression ◽  
Risk Groups ◽  
Carbon Ion Radiotherapy ◽  
Survival Models ◽  
Carbon Ion ◽  
Combined Models ◽  
Skull Base Chordoma

Skull-base chordoma (SBC) can be treated with carbon ion radiotherapy (CIRT) to improve local control (LC). The study aimed to explore the role of multi-parametric radiomic, dosiomic and clinical features as prognostic factors for LC in SBC patients undergoing CIRT. Before CIRT, 57 patients underwent MR and CT imaging, from which tumour contours and dose maps were obtained. MRI and CT-based radiomic, and dosiomic features were selected and fed to two survival models, singularly or by combining them with clinical factors. Adverse LC was given by in-field recurrence or tumour progression. The dataset was split in development and test sets and the models’ performance evaluated using the concordance index (C-index). Patients were then assigned a low- or high-risk score. Survival curves were estimated, and risk groups compared through log-rank tests (after Bonferroni correction α = 0.0083). The best performing models were built on features describing tumour shape and dosiomic heterogeneity (median/interquartile range validation C-index: 0.80/024 and 0.79/0.26), followed by combined (0.73/0.30 and 0.75/0.27) and CT-based models (0.77/0.24 and 0.64/0.28). Dosiomic and combined models could consistently stratify patients in two significantly different groups. Dosiomic and multi-parametric radiomic features showed to be promising prognostic factors for LC in SBC treated with CIRT.

scholarly journals Incidence, risk factors, and dose-volume relationship of radiation-induced rib fracture after carbon ion radiotherapy for lung cancer

2015 ◽  
Vol 55 (2) ◽  
pp. 163-166 ◽  
Author(s):  
Takanori Abe ◽  
Katsuyuki Shirai ◽  
Jun-Ichi Saitoh ◽  
Takeshi Ebara ◽  
Hirofumi Shimada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lung Cancer ◽  
Rib Fracture ◽  
Carbon Ion Radiotherapy ◽  
Carbon Ion ◽  
Dose Volume ◽  
Volume Relationship ◽  
Incidence Risk ◽  
Radiation Induced ◽  
Relationship Of

scholarly journals Proton and carbon ion radiotherapy in skull base chordomas: a prospective study based on a dual particle and a patient-customized treatment strategy

2020 ◽  
Vol 22 (9) ◽  
pp. 1348-1358 ◽  
Author(s):  
Alberto Iannalfi ◽  
Emma D’Ippolito ◽  
Giulia Riva ◽  
Silvia Molinelli ◽  
Sara Gandini ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Skull Base ◽  
Organs At Risk ◽  
High Rate ◽  
Carbon Ion Radiotherapy ◽  
Particle Therapy ◽  
Carbon Ion ◽  
Brainstem Compression ◽  
Optic Pathways ◽  
Skull Base Chordoma

Abstract Background The aim of this study is to evaluate results in terms of local control (LC), overall survival (OS), and toxicity profile and to better identify factors influencing clinical outcome of skull base chordoma treated with proton therapy (PT) and carbon ion radiotherapy (CIRT). Methods We prospectively collected and analyzed data of 135 patients treated between November 2011 and December 2018. Total prescription dose in the PT group (70 patients) and CIRT group (65 patients) was 74 Gy relative biological effectiveness (RBE) delivered in 37 fractions and 70.4 Gy(RBE) delivered in 16 fractions, respectively (CIRT in unfavorable patients). LC and OS were evaluated using the Kaplan–Meier method. Univariate and multivariate analyses were performed, to identify prognostic factors on clinical outcomes. Results After a median follow-up of 44 (range, 6–87) months, 14 (21%) and 8 (11%) local failures were observed in CIRT and PT group, respectively. Five-year LC rate was 71% in CIRT cohort and 84% in PT cohort. The estimated 5-year OS rate in the CIRT and PT group was 82% and 83%, respectively. On multivariate analysis, gross tumor volume (GTV), optic pathways, and/or brainstem compression and dose coverage are independent prognostic factors of local failure risk. High rate toxicity grade ≥3 was reported in 11% of patients. Conclusions Particle radiotherapy is an effective treatment for skull base chordoma with acceptable late toxicity. GTV, optic pathways, and/or brainstem compression and target coverage were independent prognostic factors for LC. Key Points • Proton and carbon ion therapy are effective and safe in skull base chordoma. • Prognostic factors are GTV, organs at risk compression, and dose coverage. • Dual particle therapy and customized strategy was adopted.

scholarly journals Dose–volume histogram analysis of brainstem necrosis in head and neck tumors treated using carbon-ion radiotherapy

2017 ◽  
Vol 125 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Katsuyuki Shirai ◽  
Kyohei Fukata ◽  
Akiko Adachi ◽  
Jun-ichi Saitoh ◽  
Atsushi Musha ◽  
...  
Keyword(s):  
Head And Neck ◽  
Head And Neck Tumors ◽  
Histogram Analysis ◽  
Carbon Ion Radiotherapy ◽  
Dose Volume Histogram ◽  
Carbon Ion ◽  
Neck Tumors ◽  
Dose Volume

scholarly journals The Risk Factors for Radiation Pneumonitis After Single-Fraction Carbon-Ion Radiotherapy for Lung Cancer or Metastasis

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3229
Author(s):  
Takashi Ono ◽  
Naoyoshi Yamamoto ◽  
Akihiro Nomoto ◽  
Mio Nakajima ◽  
Yuma Iwai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Interstitial Pneumonitis ◽  
Radiation Pneumonitis ◽  
Target Volume ◽  
Carbon Ion Radiotherapy ◽  
Normal Lung ◽  
Carbon Ion ◽  
Single Fraction ◽  
Dose Volume ◽  
Mean Lung Dose

There are no studies on the risk factors of radiation pneumonitis (RP) after carbon-ion radiotherapy at a dose of 50 Gy (relative biological effectiveness (RBE)) in a single fraction. The objective of this study was to identify factors associated with RP after radiotherapy, including dose–volume parameters. Ninety-eight patients without a history of thoracic radiotherapy who underwent treatment for solitary lung tumors between July 2013 and April 2016 were retrospectively analyzed. Treatment was planned using Xio-N. The median follow-up duration was 53 months, and the median clinical target volume was 32.3 mL. Three patients developed grade 2 RP, and one patient developed grade 3 interstitial pneumonitis. None of the patients developed grade 4 or 5 RP. The dose-volume parameters of the normal lung irradiated at least with 5–30 Gy (RBE), and the mean lung dose was significantly lower in patients with grade 0–1 RP than in those with grade 2–3 RP. Pretreatment with higher SP-D and interstitial pneumonitis were significant factors for the occurrence of symptomatic RP. The present study showed a certain standard for single-fraction carbon-ion radiotherapy that does not increase the risk of RP; however, further validation studies are needed.

scholarly journals Effects of the dose-volume relationship on and risk factors for maxillary osteoradionecrosis after carbon ion radiotherapy

2014 ◽  
Vol 9 (1) ◽  
pp. 92 ◽  
Author(s):  
Go Sasahara ◽  
Masashi Koto ◽  
Hiroaki Ikawa ◽  
Azusa Hasegawa ◽  
Ryo Takagi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Carbon Ion Radiotherapy ◽  
Carbon Ion ◽  
Dose Volume ◽  
Volume Relationship

scholarly journals Carbon Ion Dose Constraints in the Head and Neck and Skull Base: Review of MedAustron Institutional Protocols

2021 ◽  
Vol 8 (1) ◽  
pp. 25-35
Author(s):  
Piero Fossati ◽  
Ana Perpar ◽  
Markus Stock ◽  
Petra Georg ◽  
Antonio Carlino ◽  
...  
Keyword(s):  
Head And Neck ◽  
Local Effect ◽  
Brain Parenchyma ◽  
Carbon Ion Radiotherapy ◽  
Carbon Ion ◽  
Effect Model ◽  
Dose Volume ◽  
Ion Therapy ◽  
Dose Constraints ◽  
Fractionation Schedules

Abstract Background Dose constraints are of paramount importance for the outcome of any radiotherapy treatment. In this article, we report dose-volume constraints as well as currently used fractionation schedules for carbon ion radiotherapy as applied in MedAustron (Wiener Neustadt, Austria). Materials and Methods For fractionation schedules, both German and Japanese regimes were used. From the clinical experience of National Institute of Radiological Sciences (Chiba, Japan) and Heidelberg Ion Therapy (Heidelberg, Germany; formerly GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany) and the work by colleagues in Centro Nazionale Adroterapia Oncologica (Pavia, Italy) recalculating the dose from the microdosimetric kinetic model to the local effect model, we have set the dose constraints for critical organs of the head and neck area. Where no clinical data was available, an educated guess was made, based on data available from photon and proton series. Results We report the constraints for the optic nerve and chiasm, brainstem, spinal cord, cochlea, brain parenchyma, salivary gland, eye and adnexa, and mandibular/maxillary bone; constraints are grouped based on a fractionation scheme (German versus Japanese) and the risk of toxicity (safe, low to middle, and middle to high). Conclusion We think validation of dose constraints should present a relevant part of the activity of any carbon ion radiotherapy facility, and we anticipate future multicentric, joint evaluations.

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