Treatment Outcomes of Locally Advanced Oropharyngeal Cancer: A Comparison Between Combined Modality Radio-Chemotherapy and Two Variants of Single Modality Altered Fractionation Radiotherapy

2011 ◽  
Vol 80 (4) ◽  
pp. 1030-1036 ◽  
Author(s):  
Hosam A. Kader ◽  
Aminudin R. Mydin ◽  
Matthew Wilson ◽  
Cheryl Alexander ◽  
Jeevin Shahi ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Oropharyngeal Cancer ◽  
Locally Advanced ◽  
Altered Fractionation ◽  
Combined Modality ◽  
Radio Chemotherapy ◽  
Single Modality

MRI-guided adaptive brachytherapy for locally advanced cervix cancer: Treatment outcomes from a single institution in Hong Kong

Brachytherapy ◽  
2019 ◽  
Vol 18 (2) ◽  
pp. 171-179 ◽  
Author(s):  
Philip Yuguang Wu ◽  
Terry Pang Wai Wong ◽  
Yan Yee Chloe Yip ◽  
Tien Yee Amy Chang ◽  
Lai Kwan Lucy Chan ◽  
...  
Keyword(s):  
Hong Kong ◽  
Cancer Treatment ◽  
Treatment Outcomes ◽  
Locally Advanced ◽  
Cervix Cancer ◽  
Single Institution ◽  
Mri Guided

scholarly journals Comparison of altered fractionation schedule with concurrent chemo-radiation for squamous cell carcinoma of head and neck

2020 ◽  
Vol 8 (8) ◽  
pp. 2834
Author(s):  
Mathew Varghese K. ◽  
Geeta S. Narayanan ◽  
Bhaskar Vishwanathan ◽  
Shashidhar V. Karpurmath ◽  
Soumya Narayanan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Performance Status ◽  
Locally Advanced ◽  
Complete Response ◽  
Altered Fractionation ◽  
Fractionation Schedule ◽  
Nodal Burden

Background: Aim of the study was to compare the response of altered fractionation schedule with concurrent chemo-radiation in patients with primary and the nodal disease.Methods: Total of 40 patients (20 in each arm) with stage 1- 4 squamous cell carcinoma of the head and neck with a performance status of 0-2 (ECOG) were included in the study. Arm A was altered fractionation schedule where in patients received 6 fractions per week to a total dose of 6600 cGy in 33 fractions. In Arm B, patients received conventional radiotherapy with concurrent chemotherapy three weekly Inj. of cisplatin (100 mg/m2). Patients were evaluated for acute toxicity every week using the Acute Radiation Morbidity Scoring Criteria. The response was assessed after 6 weeks and 12 weeks post treatment using the RECIST criteria. Data was statistically analyzed.Results: Seventeen patients in Arm A and 18 patients in Arm B completed the treatment. At the end of three months, In Arm A, 7 patients had complete response and in Arm B, 9 patients had complete response of the primary (p>0.05).  When the complete nodal response was compared in both the arms, there was no difference (2 vs 4 in Arm A vs Arm B resp.). But there were more partial nodal responders in Arm B (p = 0.016). The acute toxicities were comparable in both the arms.Conclusions: Altered fraction radiotherapy can be used in early lesions with minimal nodal burden but with locally advanced disease or large nodal burden addition of chemotherapy should not be avoided.

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