Cardiovascular Event Reporting in Clinical Trials Involving Chest Radiation Therapy

2020 ◽  
Vol 108 (3) ◽  
pp. S53-S54
Author(s):  
R.N. Prasad ◽  
M. McIntyre ◽  
R.R. Carter ◽  
A. Guha ◽  
V. Yildiz ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Radiation Therapy ◽  
Cardiovascular Event ◽  
Event Reporting

scholarly journals Radiation Therapy Oncology Group (RTOG)

2006 ◽  
Vol 9 (S1) ◽  
pp. 411-418
Author(s):  
Keyword(s):  
Clinical Trials ◽  
Radiation Therapy ◽  
Radiation Therapy Oncology Group ◽  
Phase Iii ◽  
Partial Breast Irradiation ◽  
List Type ◽  
Breast Irradiation ◽  
Oncology Group ◽  
Duct Carcinoma ◽  
Conformal Radiation Therapy

This section provides current contact details and a summary of recent or ongoing clinical trials being coordinated by Radiation therapy Oncology group (RTOG). Clinical trials include: RTOG 9804: Phase III trial of observation ± tamoxifen versus RT ± tamoxifen for good risk duct carcinoma in-situ(DCIS) of the female breast.NSABP B-39/RTOG 0413: A randomized phase III study of conventional whole breast irradiation (WBI) versus partial breast irradiation (PBI) for women with stage 0, I, or II breast cancer.A phase II trial to evaluate three dimensional conformal radiation therapy (3D-RT) confined to the region of the lumpectomy cavity for stage I and II breast carcinoma.

scholarly journals Point/counterpoint: early-stage Hodgkin lymphoma and the role of radiation therapy

Hematology ◽  
2012 ◽  
Vol 2012 (1) ◽  
pp. 313-321 ◽  
Author(s):  
Ralph M. Meyer ◽  
Richard T. Hoppe
Keyword(s):  
Clinical Trials ◽  
Radiation Therapy ◽  
Hodgkin Lymphoma ◽  
Early Stage ◽  
Trial Protocol ◽  
Radiation Oncologist ◽  
Limited Stage ◽  
Considerable Debate

Abstract The results of recent clinical trials for the management of limited-stage Hodgkin lymphoma have led to considerable debate, especially regarding the role of radiation therapy. This review highlights those recent trials and provides perspectives regarding their interpretation from a radiation oncologist and a hematologist. The trial protocol is available at http://www.nejm.org/doi/suppl/10.1056/NEJMoa1111961/suppl_file/nejmoa1111961_protocol.pdf.

scholarly journals A case of long-term disease control in a patient with disseminated melanoma with synchronous detection of multiple brain metastases

2018 ◽  
Vol 5 (4) ◽  
pp. 98-105
Author(s):  
M. I. Kurzhupov
Keyword(s):  
Clinical Trials ◽  
Radiation Therapy ◽  
Targeted Therapy ◽  
Clinical Case ◽  
Total Duration ◽  
Skin Melanoma ◽  
Synchronous Detection ◽  
Term Survival ◽  
Stage Of Diagnosis

The article presents clinical trials data of melanoma with brain metastasis and a clinical case of long-term survival of a patient with disseminated skin melanoma and synchronous multiple metastatic brain damage by controlling a tumor disease using modern antitumor treatment, including targeted therapy, immunotherapy, radiation therapy, radiosurgery and neurosurgery (at the stage of diagnosis). The total duration of life after detection of the disease is 22 months, with an expected 2-3 months.

Combining Low-Dose Radiation Therapy and Magnetic Resonance Guided Focused Ultrasound to Reduce Amyloid-β Deposition in Alzheimer’s Disease

2021 ◽  
pp. 1-4
Author(s):  
Paolo Farace ◽  
Stefano Tamburin
Keyword(s):  
Alzheimer’S Disease ◽  
Clinical Trials ◽  
Radiation Therapy ◽  
White Matter ◽  
Magnetic Resonance ◽  
Low Dose ◽  
Focused Ultrasound ◽  
Amyloid Β ◽  
Low Dose Radiation ◽  
Dose Radiation

Amyloid-β deposition is one of the neuropathological hallmarks of Alzheimer’s disease (AD), but pharmacological strategies toward its reduction are poorly effective. Preclinical studies indicate that low-dose radiation therapy (LD-RT) may reduce brain amyloid-β. Animal models and proof-of-concept preliminary data in humans have shown that magnetic resonance guided focused ultrasound (MRgFUS) can reversibly open the blood-brain-barrier and facilitate the delivery of targeted therapeutics to the hippocampus, to reduce amyloid-β and promote neurogenesis in AD. Ongoing clinical trials on AD are exploring whole-brain LD-RT, which may damage radio-sensitive structures, i.e., hippocampus and white matter, thus contributing to reduced neurogenesis and radiation-induced cognitive decline. However, selective irradiation of cortical amyloid-β plaques through advanced LD-RT techniques might spare the hippocampus and white matter. We propose combined use of advanced LD-RT and targeted drug delivery through MRgFUS for future clinical trials to reduce amyloid-β deposition in AD since its preclinical stages.

scholarly journals Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis

Medicina ◽  
2019 ◽  
Vol 55 (2) ◽  
pp. 25 ◽  
Author(s):  
Goda Daugėlaitė ◽  
Kristė Užkuraitytė ◽  
Eglė Jagelavičienė ◽  
Aleksas Filipauskas
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Radiation Therapy ◽  
Laser Therapy ◽  
Oral Mucositis ◽  
Oral Hygiene ◽  
Royal Jelly ◽  
Review Of Literature ◽  
Treatment And Prevention ◽  
Prevention Methods

Background and objectives: Oral mucositis is one of the main adverse events of cancer treatment with chemotherapy or radiation therapy. It presents as erythema, atrophy or/and ulceration of oral mucosa. It occurs in almost all patients, who receive radiation therapy of the head and neck area and from 20% to 80% of patients who receive chemotherapy. There are few clinical trials in the literature proving any kind of treatment or prevention methods to be effective. Therefore, the aim of this study is to perform systematic review of literature and examine the most effective treatment and prevention methods for chemotherapy or/and radiotherapy induced oral mucositis. Materials and methods: Clinical human trials, published from 1 January 2007 to 31 December 2017 in English, were included in this systematic review of literature. Preferred reporting items for systematic reviews and meta-analysis (PRISMA) protocol was followed while planning, providing objectives, selecting studies and analyzing data for this systematic review. “MEDLINE” and “PubMed Central” databases were used to search eligible clinical trials. Clinical trials researching medication, oral hygiene, cryotherapy or laser therapy efficiency in treatment or/and prevention of oral mucositis were included in this systematic review. Results: Results of the studies used in this systematic review of literature showed that laser therapy, cryotherapy, professional oral hygiene, antimicrobial agents, Royal jelly, L. brevis lozenges, Zync supplementation and Benzydamine are the best treatment or/and prevention methods for oral mucositis. Conclusions: Palifermin, Chlorhexidine, Smecta, Actovegin, Kangfuxin, L. brevis lozenges, Royal jelly, Zync supplement, Benzydamine, cryotherapy, laser therapy and professional oral hygiene may be used in oral mucositis treatment and prevention.

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