scholarly journals A novel method for drug-adverse event extraction using machine learning

2019 ◽  
Vol 17 ◽  
pp. 100190 ◽  
Author(s):  
Kajal Negi ◽  
Arun Pavuri ◽  
Ladle Patel ◽  
Chirag Jain
Keyword(s):  
Machine Learning ◽  
Adverse Event ◽  
Event Extraction ◽  
Drug Adverse Event ◽  
Novel Method

A Novel Amino Acid Sequence-based Computational Approach to Predicting Cell-penetrating Peptides

2019 ◽  
Vol 15 (3) ◽  
pp. 206-211 ◽  
Author(s):  
Jihui Tang ◽  
Jie Ning ◽  
Xiaoyan Liu ◽  
Baoming Wu ◽  
Rongfeng Hu
Keyword(s):  
Machine Learning ◽  
Amino Acid ◽  
Amino Acid Position ◽  
Cell Penetrating Peptides ◽  
Support Vector ◽  
Cell Penetration ◽  
Drug Candidates ◽  
Machine Learning Model ◽  
Cell Penetrating ◽  
Novel Method

<P>Introduction: Machine Learning is a useful tool for the prediction of cell-penetration compounds as drug candidates. </P><P> Materials and Methods: In this study, we developed a novel method for predicting Cell-Penetrating Peptides (CPPs) membrane penetrating capability. For this, we used orthogonal encoding to encode amino acid and each amino acid position as one variable. Then a software of IBM spss modeler and a dataset including 533 CPPs, were used for model screening. </P><P> Results: The results indicated that the machine learning model of Support Vector Machine (SVM) was suitable for predicting membrane penetrating capability. For improvement, the three CPPs with the most longer lengths were used to predict CPPs. The penetration capability can be predicted with an accuracy of close to 95%. </P><P> Conclusion: All the results indicated that by using amino acid position as a variable can be a perspective method for predicting CPPs membrane penetrating capability.</P>

Evaluation of Drug Adverse Event Intake and Reporting in a Medical Information Service

2011 ◽  
Vol 45 (6) ◽  
pp. 767-773 ◽  
Author(s):  
Pamela D. Allen ◽  
Robert J. Fuentes ◽  
Michael J. Hoopes ◽  
Greg Susla
Keyword(s):  
Adverse Event ◽  
Medical Information ◽  
Information Service ◽  
Drug Adverse Event

GUESS: projecting machine learning scores to well-calibrated probability estimates for clinical decision-making

2018 ◽  
Vol 35 (14) ◽  
pp. 2458-2465 ◽  
Author(s):  
Johanna Schwarz ◽  
Dominik Heider
Keyword(s):  
Machine Learning ◽  
Decision Support ◽  
Clinical Decision Support ◽  
State Of The Art ◽  
Clinical Decision Support Systems ◽  
Clinical Decision ◽  
Calibration Method ◽  
Probability Estimates ◽  
Calibration Methods ◽  
Novel Method

Abstract Motivation Clinical decision support systems have been applied in numerous fields, ranging from cancer survival toward drug resistance prediction. Nevertheless, clinical decision support systems typically have a caveat: many of them are perceived as black-boxes by non-experts and, unfortunately, the obtained scores cannot usually be interpreted as class probability estimates. In probability-focused medical applications, it is not sufficient to perform well with regards to discrimination and, consequently, various calibration methods have been developed to enable probabilistic interpretation. The aims of this study were (i) to develop a tool for fast and comparative analysis of different calibration methods, (ii) to demonstrate their limitations for the use on clinical data and (iii) to introduce our novel method GUESS. Results We compared the performances of two different state-of-the-art calibration methods, namely histogram binning and Bayesian Binning in Quantiles, as well as our novel method GUESS on both, simulated and real-world datasets. GUESS demonstrated calibration performance comparable to the state-of-the-art methods and always retained accurate class discrimination. GUESS showed superior calibration performance in small datasets and therefore may be an optimal calibration method for typical clinical datasets. Moreover, we provide a framework (CalibratR) for R, which can be used to identify the most suitable calibration method for novel datasets in a timely and efficient manner. Using calibrated probability estimates instead of original classifier scores will contribute to the acceptance and dissemination of machine learning based classification models in cost-sensitive applications, such as clinical research. Availability and implementation GUESS as part of CalibratR can be downloaded at CRAN.

scholarly journals A Novel Method for Sea-Land Clutter Separation Using Regularized Randomized and Kernel Ridge Neural Networks

Sensors ◽  
2020 ◽  
Vol 20 (22) ◽  
pp. 6491
Author(s):  
Le Zhang ◽  
Jeyan Thiyagalingam ◽  
Anke Xue ◽  
Shuwen Xu
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Neural Networks ◽  
Classification Accuracy ◽  
Signal Amplitude ◽  
Statistical Characteristics ◽  
Support Vector ◽  
Amplitude Change ◽  
Novel Method

Classification of clutter, especially in the context of shore based radars, plays a crucial role in several applications. However, the task of distinguishing and classifying the sea clutter from land clutter has been historically performed using clutter models and/or coastal maps. In this paper, we propose two machine learning, particularly neural network, based approaches for sea-land clutter separation, namely the regularized randomized neural network (RRNN) and the kernel ridge regression neural network (KRR). We use a number of features, such as energy variation, discrete signal amplitude change frequency, autocorrelation performance, and other statistical characteristics of the respective clutter distributions, to improve the performance of the classification. Our evaluation based on a unique mixed dataset, which is comprised of partially synthetic clutter data for land and real clutter data from sea, offers improved classification accuracy. More specifically, the RRNN and KRR methods offer 98.50% and 98.75% accuracy, outperforming the conventional support vector machine and extreme learning based solutions.

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