scholarly journals Bio-guided fractionation of extracts of Geranium robertianum L.: Relationship between phenolic profile and biological activity

2017 ◽  
Vol 108 ◽  
pp. 543-552 ◽  
Author(s):  
V.C. Graça ◽  
Lillian Barros ◽  
Ricardo C. Calhelha ◽  
Maria Inês Dias ◽  
Isabel C.F.R. Ferreira ◽  
...  
Keyword(s):  
Biological Activity ◽  
Phenolic Profile ◽  
Geranium Robertianum

Phenolic profile and biological activity of Plantago bellardii all

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
I Beara ◽  
M Lesjak ◽  
D Četojević-Simin ◽  
N Simin ◽  
K Balog ◽  
...  
Keyword(s):  
Biological Activity ◽  
Phenolic Profile

scholarly journals Antioxidant and Antimicrobial Potential of Phenolic Metabolites from Traditionally Used Mediterranean Herbs and Spices

Foods ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 579 ◽  
Author(s):  
Mekinić ◽  
Skroza ◽  
Ljubenkov ◽  
Katalinić ◽  
Šimat
Keyword(s):  
Biological Activity ◽  
Foodborne Pathogens ◽  
Radical Scavenging ◽  
Antimicrobial Activities ◽  
Phenolic Profile ◽  
Gram Positive Bacteria ◽  
Phenolic Profiles ◽  
Radical Scavenging Properties ◽  
And Staphylococcus Aureus ◽  
Antibacterial Potential

The phenolic extracts of fifteen Mediterranean medicinal plants, as well as their antioxidant and antimicrobial activities were investigated to grade their potential as additives in the food industry. Phenolic profiles of plant extracts were determined spectrophotometrically (total phenolics and phenolic subgroups) while individual compounds were identified using chromatographic assays. The biological activity of samples was determined using five antioxidant assays, while the antibacterial potential was determined against six foodborne pathogens (Camplyobacter coli, Escherichia coli, Salmonela Infantis, Bacillus cereus, Listeria monocytogenes, and Staphylococcus aureus). The results showed significant variations in phenolic profile of plants and consequently their biological activity. Bearberry contained the highest concentration of phenolics, was extremely rich in non-flavonoids and also had the highest amount of catechins that resulted with good reducing and free radical scavenging properties and low chelating activity. All extracts were not effective against tested microorganisms with Gram-positive bacteria being more sensitive (especially S. aureus). The most effective extracts were St. Johns wort against S. aureus with minimal inhibitory concentration (MIC) of 1.00 mg/mL), bay laurel and nettle against B. cereus (MICs of 1.67 mg/mL), and woodland strawberry against L. monocytogenes (MIC of 3.33 mg/mL).

scholarly journals Biological Activity of Phenolic Compounds in Extra Virgin Olive Oils through Their Phenolic Profile and Their Combination with Anticancer Drugs Observed in Human Cervical Carcinoma and Colon Adenocarcinoma Cells

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 453 ◽  
Author(s):  
Jelena Torić ◽  
Anamaria Brozovic ◽  
Mirela Baus Lončar ◽  
Cvijeta Jakobušić Brala ◽  
Ana Karković Marković ◽  
...  
Keyword(s):  
Biological Activity ◽  
Olive Oil ◽  
Anticancer Drugs ◽  
Anticancer Agents ◽  
Biological Effect ◽  
Dependent Manner ◽  
Phenolic Profile ◽  
Virgin Olive Oils ◽  
Olive Oils

The roles of phenolics from olive oils as effective anticancer agents have been documented in various in vitro studies of different cancer cells lines, but the relationship between the phenolic profile of olive oil and its biological activity needs more elucidation. In this study, we analysed phenolic profiles of extra virgin olive oils (EVOOs) from different autochthonous cultivars from Croatia (Oblica, Bjelica, Buža, Žižolera) and investigated the biological effect of EVOO phenolic extracts (EVOO-PEs) on human cervical (HeLa) and human colon (SW48) cancer cell lines alone and in combination with cisplatin (cDDP), carboplatin (CBP), 5-fluorouracil (5-FU) and irinotecan. The quantitative evaluation of olive oil polyphenols was performed by HPLC-DAD and spectrophotometric analysis. The biological effect of EVOO-PEs alone and in combination with anticancer drugs was measured by MTT assay. Analysed EVOO-PEs differ in phenolic profile and inhibited HeLa and SW48 cells in a dose-dependent manner. Further, it is shown that EVOO-PEs (Oblica-Sea, Buža and Žižolera), in combination with anticancer drugs, increase the metabolic activity of HeLa and SW48 cells and have a protective role. These data imply careful consummation of olive oil during chemotherapy of cancer patients.

scholarly journals Phenolic profile and biological activity of Hypericum perforatum L.: Can roots be considered as a new source of natural compounds?

2018 ◽  
Vol 117 ◽  
pp. 301-310 ◽  
Author(s):  
O. Tusevski ◽  
M. Krstikj ◽  
J.P. Stanoeva ◽  
M. Stefova ◽  
S. Gadzovska Simic
Keyword(s):  
Biological Activity ◽  
Hypericum Perforatum ◽  
Natural Compounds ◽  
Phenolic Profile ◽  
Hypericum Perforatum L

scholarly journals Comprehensive Characterization of Extractable Phenolic Compounds by UPLC-PDA-ESI-QqQ of Buddleja scordioides Plants Elicited with Salicylic Acid

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
J. O. Díaz-Rivas ◽  
R. F. González-Laredo ◽  
J. A. Chávez-Simental ◽  
J. B. Montoya-Ayón ◽  
M. R. Moreno-Jiménez ◽  
...  
Keyword(s):  
Biological Activity ◽  
Salicylic Acid ◽  
Phenolic Compounds ◽  
Phenolic Profile ◽  
Phytochemical Composition ◽  
Biological Potential ◽  
Medicinal Properties ◽  
Metabolites Production ◽  
Comprehensive Characterization

Buddleja scordioides has a rich phytochemical composition and reported medicinal properties. An increase in its secondary metabolites production could improve its functional properties. A strategy to enhance its biological potential is to subject the plant to elicitation with phytohormones such as salicylic acid under controlled environmental conditions. The present study explores the effect of exogenous application of three salicylic acid levels as elicitation treatment in B. scordioides plants. Phenolic profile, enzymatic activities, and antioxidant capacity were evaluated. Elicitation with 100 µM of salicylic acid resulted in the biosynthesis of phenolic compounds with recognized biological activity.

Fractionation of the more active extracts of Geranium molle L.: a relationship between their phenolic profile and biological activity

2018 ◽  
Vol 9 (4) ◽  
pp. 2032-2042 ◽  
Author(s):  
V. C. Graça ◽  
Maria Inês Dias ◽  
Lillian Barros ◽  
Ricardo C. Calhelha ◽  
P. F. Santos ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Phenolic Profile ◽  
Human Tumor Cell Lines ◽  
Geranium Molle

Active extracts of Geranium molle L. were fractionated and the fractions were evaluated for their antioxidant activity and cytotoxicity against several human tumor cell lines, and their phenolic profile was determined.

Antioxidant and anti-inflammatory activities of Geranium robertianum L. decoctions

2017 ◽  
Vol 8 (9) ◽  
pp. 3355-3365 ◽  
Author(s):  
Marcelo D. Catarino ◽  
Artur M. S. Silva ◽  
Maria Teresa Cruz ◽  
Susana M. Cardoso
Keyword(s):  
Phenolic Profile ◽  
Geranium Robertianum ◽  
Anti Inflammatory

The phenolic profile ofGeranium robertianumL. decoctions as well as their antioxidant and anti-inflammatory activities were investigated.

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

Effects of Vincristine on Endothelial Microtubules in the Spinal Cord

1976 ◽  
Vol 34 ◽  
pp. 58-59
Author(s):  
John L. Beggs ◽  
John D. Waggener ◽  
Wanda Miller
Keyword(s):  
Spinal Cord ◽  
Biological Activity ◽  
Horseradish Peroxidase ◽  
Transport Mechanism ◽  
Vasogenic Edema ◽  
Vesicular Transport ◽  
Close Proximity

Microtubules (MT) are versatile organelles participating in a wide variety of biological activity. MT involvement in the movement and transport of cytoplasmic components has been well documented. In the course of our study on trauma-induced vasogenic edema in the spinal cord we have concluded that endothelial vesicles contribute to the edema process. Using horseradish peroxidase as a vascular tracer, labeled endothelial vesicles were present in all situations expected if a vesicular transport mechanism was in operation. Frequently,labeled vesicles coalesced to form channels that appeared to traverse the endothelium. The presence of MT in close proximity to labeled vesicles sugg ested that MT may play a role in vesicular activity.

Isothiazol-3(2 H )-ones, Part I: Synthesis, Reactions and Biological Activity

2002 ◽  
Vol 23 (1) ◽  
pp. 79-121 ◽  
Author(s):  
Kathleen Taubert ◽  
Susanne Kraus ◽  
Bärbel Schulze
Keyword(s):  
Biological Activity ◽  
Synthesis Reactions
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