Comprehensive analysis of the expression and prognostic value of CXC chemokines in colorectal cancer

2020 ◽  
Vol 89 ◽  
pp. 107077
Author(s):  
Li Yu ◽  
Xinmei Yang ◽  
Chuchu Xu ◽  
Jiachun Sun ◽  
Zhipeng Fang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Comprehensive Analysis

scholarly journals Prognostic Value of the Pretreatment Systemic Immune-Inflammation Index in Patients with Colorectal Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Jing Li ◽  
Jingjing Shao ◽  
Xunlei Zhang ◽  
Xin Chen ◽  
Wenjing Zhao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Disease Free Survival ◽  
Progression Free Survival ◽  
Comprehensive Analysis ◽  
Cochrane Library ◽  
Free Survival ◽  
Immune Inflammation ◽  
The Cochrane Library ◽  
Disease Free

Background. Multiple studies have reported the significance of the systemic immune-inflammation index (SII) in the prognosis of colorectal cancer (CRC), but no consensus has yet been reached. The purpose of this study was to systematically assess the prognostic value of SII in patients with CRC. Materials and Methods. We performed a systematic literature search in PubMed, Embase, and the Cochrane Library for eligible studies. The correlation between pretreatment SII and overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) in CRC patients was evaluated by combining the hazard ratio (HR) and 95% confidence interval (CI). Results. Twelve studies involving 3919 patients were included. Comprehensive analysis results showed that high SII indicated poor OS in CRC patients ( HR = 1.777 , 95% CI: 1.328-2.376). Compared with patients with low SII values, patients with high SII had lower PFS ( HR = 1.658 , 95% CI: 1.189-2.311). Subgroup analysis further verified the above results. Conclusions. SII may be a noninvasive and powerful tool for predicting survival outcomes in CRC patients. However, more well-designed studies are needed to validate our findings.

Prognostic Value of Erythrocyte Sedimentation Rate in Patients with Colorectal Cancer

2008 ◽  
Vol 24 (5) ◽  
pp. 351
Author(s):  
Young Ki Kim ◽  
Seong Woo Hong ◽  
Jung Woo Chun ◽  
Yeo Goo Chang ◽  
In Wook Paik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Prognostic Value ◽  
Erythrocyte Sedimentation

scholarly journals Comprehensive analysis of lncRNA-miRNA-mRNA regulatory networks for microbiota-mediated colorectal cancer associated with immune cell infiltration

Bioengineered ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 3410-3425
Author(s):  
Xiangzhou Tan ◽  
Linfeng Mao ◽  
Changhao Huang ◽  
Weimin Yang ◽  
Jianping Guo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Regulatory Networks ◽  
Immune Cell ◽  
Comprehensive Analysis ◽  
Cell Infiltration ◽  
Immune Cell Infiltration

scholarly journals Metastatic heterogeneity of the consensus molecular subtypes of colorectal cancer

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Peter W. Eide ◽  
Seyed H. Moosavi ◽  
Ina A. Eilertsen ◽  
Tuva H. Brunsell ◽  
Jonas Langerud ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Principal Components ◽  
Prognostic Value ◽  
Tumor Heterogeneity ◽  
Molecular Subtypes ◽  
R Package ◽  
Data Set ◽  
Primary Tumors ◽  
External Data

AbstractGene expression-based subtypes of colorectal cancer have clinical relevance, but the representativeness of primary tumors and the consensus molecular subtypes (CMS) for metastatic cancers is not well known. We investigated the metastatic heterogeneity of CMS. The best approach to subtype translation was delineated by comparisons of transcriptomic profiles from 317 primary tumors and 295 liver metastases, including multi-metastatic samples from 45 patients and 14 primary-metastasis sets. Associations were validated in an external data set (n = 618). Projection of metastases onto principal components of primary tumors showed that metastases were depleted of CMS1-immune/CMS3-metabolic signals, enriched for CMS4-mesenchymal/stromal signals, and heavily influenced by the microenvironment. The tailored CMS classifier (available in an updated version of the R package CMScaller) therefore implemented an approach to regress out the liver tissue background. The majority of classified metastases were either CMS2 or CMS4. Nonetheless, subtype switching and inter-metastatic CMS heterogeneity were frequent and increased with sampling intensity. Poor-prognostic value of CMS1/3 metastases was consistent in the context of intra-patient tumor heterogeneity.

scholarly journals 126P Prognostic value of blood-based fibrosis biomarkers in patients with metastatic colorectal cancer receiving chemotherapy and bevacizumab

2020 ◽  
Vol 31 ◽  
pp. S290
Author(s):  
N.I. Nissen ◽  
S. Kehlet ◽  
M.K. Boisen ◽  
M. Liljefors ◽  
C. Jensen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Prognostic Value

scholarly journals The prognostic value of KRAS mutations in patients with colorectal cancer

2012 ◽  
Vol 28 (5) ◽  
pp. 1579-1584 ◽  
Author(s):  
YASUHIRO INOUE ◽  
SUSUMU SAIGUSA ◽  
TAKASHI IWATA ◽  
YOSHINAGA OKUGAWA ◽  
YUJI TOIYAMA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Kras Mutations
Sign in / Sign up

Export Citation Format

Share Document