Therapeutic potential of bicyclol in liver diseases: Lessons from a synthetic drug based on herbal derivative in traditional Chinese medicine

2021 ◽  
Vol 91 ◽  
pp. 107308
Author(s):  
Tianming Zhao ◽  
Lihong Mao ◽  
Zihan Yu ◽  
Yangyang Hui ◽  
Hongjuan Feng ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Liver Diseases ◽  
Therapeutic Potential ◽  
Synthetic Drug

Cardiovascular Modulating Effects of Magnolol and Honokiol, Two Polyphenolic Compounds from Traditional Chinese Medicine-Magnolia Officinalis

2020 ◽  
Vol 21 (6) ◽  
pp. 559-572 ◽  
Author(s):  
Yuan Yuan ◽  
Xiaocui Zhou ◽  
Yuanyuan Wang ◽  
Yan Wang ◽  
Xiangyan Teng ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cardiac Hypertrophy ◽  
Therapeutic Potential ◽  
Current Data ◽  
Polyphenolic Compounds ◽  
Comprehensive Review ◽  
Magnolia Officinalis

Honokiol and its isomer magnolol are poly-phenolic compounds isolated from the Magnolia officinalis that exert cardiovascular modulating effects via a variety of mechanisms. They are used as blood-quickening and stasis-dispelling agents in Traditional Chinese Medicine and confirmed to have therapeutic potential in atherosclerosis, thrombosis, hypertension, and cardiac hypertrophy. This comprehensive review summarizes the current data regarding the cardioprotective mechanisms of those compounds and identifies areas for further research.

Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCγ1- and Ca2+-dependent apoptosis

Blood ◽  
2008 ◽  
Vol 111 (4) ◽  
pp. 2354-2363 ◽  
Author(s):  
Sven Baumann ◽  
Stefanie C. Fas ◽  
Marco Giaisi ◽  
Wolfgang W. Müller ◽  
Anette Merling ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Potential ◽  
Human T Cell ◽  
Voltage Dependent ◽  
Ca2 Channels ◽  
Malignant T Cells

Herbs have successfully been used in traditional Chinese medicine for centuries. However, their curative mechanisms remain largely unknown. In this study, we show that Wogonin, derived from the traditional Chinese medicine Huang-Qin (Scutellaria baicalensis Georgi), induces apoptosis in malignant T cells in vitro and suppresses growth of human T-cell leukemia xenografts in vivo. Importantly, Wogonin shows almost no toxicity on T lymphocytes from healthy donors. Wogonin induces prolonged activation of PLCγ1 via H2O2 signaling in malignant T cells, which leads to sustained elevation of cytosolic Ca2+ in malignant but not normal T cells. Subsequently, a Ca2+ overload leads to disruption of the mitochondrial membrane. The selective effect of Wogonin is due to its differential regulation of the redox status of malignant versus normal T cells. In addition, we show that the L-type voltage-dependent Ca2+ channels are involved in the intracellular Ca2+ mobilization in T cells. Furthermore, we show that malignant T cells possess elevated amounts of voltage-dependent Ca2+ channels compared with normal T cells, which further enhance the cytotoxicity of Wogonin for malignant T cells. Taken together, our data show a therapeutic potential of Wogonin for the treatment of hematologic malignancies.

scholarly journals Leonurine, a Potential Agent of Traditional Chinese Medicine: Recent Updates and Future Perspectives

2016 ◽  
Vol 11 (11) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Di Yang ◽  
Wanwan Jia ◽  
Yi Zhun Zhu
Keyword(s):  
Natural Products ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Future Perspectives ◽  
Effective Agent ◽  
Recent Advances

Herba Leonuri, also named Chinese Motherwort, has been extensively investigated as an effective agent on the uterus system. Our group has been studying the natural products of Herba Leonuri for several years, and during this period, many biological activities of the drug were recognized. Leonurine (4-guanidino- N-butyl-syringate) is an alkaloid present in Herba Leonuri. Recently, growing evidence has highlighted the therapeutic potential of leonurine in multiple diseases, especially cardiovascular. In this review, we discuss the biological activities of leonurine, as well as recent advances involving this alkaloid.

Therapeutic Potential of Wenshen Xiaozheng Tang, a Traditional Chinese Medicine Prescription, for Treating Endometriosis

2013 ◽  
Vol 20 (10) ◽  
pp. 1215-1223 ◽  
Author(s):  
Zhenzhen Zhang ◽  
Chunping Hu ◽  
Weiwei Tang ◽  
Tao Gui ◽  
Ruyun Qian ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Potential ◽  
Medicine Prescription ◽  
Chinese Medicine Prescription

scholarly journals Therapeutic Potential of Traditional Chinese Medicine on Inflammatory Diseases

2013 ◽  
Vol 3 (3) ◽  
pp. 142-151 ◽  
Author(s):  
Wen-Hsin Tsai ◽  
Chih-Ching Yang ◽  
Ping-Chia Li ◽  
Wang-Chuan Chen ◽  
Chiang-Ting Chien
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Potential ◽  
Inflammatory Diseases

scholarly journals The potential of MLC901 (NeuroAiD II™), a traditional Chinese medicine

2019 ◽  
Vol 2 (2) ◽  
pp. 18-24
Author(s):  
Suhua Huang ◽  
Mingxia Lin ◽  
Xiaowei Pan ◽  
Qiwen Tan ◽  
Kai-Leng Tan
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Potential ◽  
Neurological Deficits ◽  
Inflammatory Infiltration ◽  
Research Directions ◽  
Beneficial Effects ◽  
Target Drug ◽  
Single Target ◽  
The Individual

Stroke, also known as cerebral ischemia, is a common neurological disease. The therapeutic potential of MLC901 (NeuroAiD II™) has been reported in clinical trials on traumatic brain injury as well as in animal and cell models. MLC901 reduced the infarction size, ischemia-induced neurological deficits and pro-inflammatory infiltration of phagocyte. It also inhibited the ischemia-induced expression of pro-inflammatory mediators and Prx6, TLR4 signalling, and phosphorylation of NFκB. We found that the beneficial effects of MLC901 are in coherent with studies performed on the individual active ingredient. MLC901 may develop its efficacy through a synergistic effect via nine herbal extracts. MLC901 is a multifaceted traditional Chinese medicine. A cocktail of herbs provides a broader spectrum of targets. This may surpass single-target drug treatment in terms of side effect and therapeutic efficacy. MLC901 leads to various potential research directions on the development or improvement of a feasible, effective and promising herbal formulation for treating stroke patients.

A Metabonomics Approach to Drug Toxicology in Liver Disease and its Application in Traditional Chinese Medicine

2019 ◽  
Vol 20 (4) ◽  
pp. 292-300 ◽  
Author(s):  
Guangyue Su ◽  
Haifeng Wang ◽  
Jiao Bai ◽  
Gang Chen ◽  
Yuehu Pei
Keyword(s):  
Liver Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Liver Diseases ◽  
Biomarker Discovery ◽  
Protective Mechanisms ◽  
Metabolic Transformation ◽  
Drug Interventions ◽  
Endogenous Metabolites

Background: The progression of liver disease causes metabolic transformation in vivo and thus affects corresponding endogenous small molecular compounds. Metabonomics is a powerful technology which is able to assess global low-molecular-weight endogenous metabolites in a biological system. This review is intended to provide an overview of a metabonomics approach to the drug toxicology of diseases of the liver. Methods: The regulation of, and relationship between, endogenous metabolites and diseases of the liver is discussed in detail. Furthermore, the metabolic pathways involved in drug interventions of liver diseases are reviewed. Evaluation of the protective mechanisms of traditional Chinese medicine in liver diseases using metabonomics is also reviewed. Examples of applications of metabolite profiling concerning biomarker discovery are highlighted. In addition, new developments and future prospects are described. Results: Metabonomics can measure changes in metabolism relating to different stages of liver disease, so metabolic differences can provide a basis for the diagnosis, treatment and prognosis of various diseases. Conclusion: Metabonomics has great advantages in all aspects of the therapy of liver diseases, with good prospects for clinical application.

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