Positive results bias in pediatric ophthalmology scientific publications

Author(s):  
Assaf Gershoni ◽  
Meydan Ben Ishai ◽  
Igor Vainer ◽  
Michael Mimouni ◽  
Eedy Mezer
Author(s):  
Galina Stepanovna Merzlikina

The article deals with the problems of assessing the economic efficiency of smart production and ways to resolve them. It has been found that Smart Manufacturing is currently becoming a goal in itself and a guarantor of successful development of industrial business. A comparative analysis of scientific publications to clarify the content of the concept of Smart Manufacturing is carried out, it is revealed that it is necessary to distinguish between intelligent and smart production, which are currently used as synonyms. Analysis of the practice of organizing smart manufacturing has shown that often the process of creating Smart Manufacturing pursues the goal of participating in a popular, useful process with the expectation of future “blurry” positive results; but there are also the actual results in the form of cost savings (better organization of the production process), an increase in production and an increase in labor productivity. All enterprises and organizations quite clearly understand the process of creating a specific smart production with detailing of individual stages, therefore, the specific goals of Smart Manufacturing should be specified taking into account a specific enterprise, but at the same time, standardized for the possibility of a comparative assessment of economic efficiency. It has been proved that traditional economic indicators of efficiency are used to assess the economic efficiency of Smart Manufacturing; but for the organization it is necessary to form a special system of performance indicators based on the theory of management by goals. It is determined that the main factor of Smart Manufacturing is innovative capital, since smart manufacturing is innovative by definition. Possible options for the formation and combination of goals and objectives of Smart Manufacturing and innovation capital are considered. The content and structure of the regulation for assessing the economic efficiency of Smart Manufacturing are proposed


2020 ◽  
Author(s):  
Frédérique Thonon ◽  
Swati Perrot ◽  
Abhijna Vithal Yergolkar ◽  
Olivia Rousset-Torrente ◽  
James W Griffith ◽  
...  

BACKGROUND Migrants may face significant delays and barriers in accessing health care, especially those who do not speak fluently the language of the host country. Some applications (apps) or electronic tools have been specifically developed to be used in medical consultations to facilitate the dialogue between health care professionals and migrants with low language proficiency, as well as apps to promote health amongst migrants. OBJECTIVE We conducted a systematic review to examine the evidence related to the development, adaptation, acceptability and effectiveness of electronic tools designed to help health care providers communicate with, or promote health amongst, migrants having a low proficiency in the language of the country of origin and/or low health literacy. METHODS We conducted a search of three scientific publications databases: Pubmed, Scopus and Embase. The study selection was performed by two researchers independently. We collected data about: general information about the app, information about health literacy and cultural adaptation, information about the development of the app, evidence about the app’s acceptability/efficacy and information about the apps’ use. Data was collected by two researchers independently and results were compared for triangulation and synthesis. Results were reported according to the PRISMA checklist. RESULTS We included 61 articles presenting a total of 48 applications. About one third of them (N=16) were designed solely to facilitate the interaction between migrants and a health care provider during a consultation, while the remaining two thirds (N=32) were designed to promote health amongst migrants with a language barrier. Thirty-two applications (67%) had their acceptability evaluated. Amongst them, 78% reported an overall good or very good acceptability, 3% reported an adequate acceptability. Half of the applications had their efficacy evaluated. Amongst them, for 5 of them the study was ongoing (21%); half had significant positive results, with 12% having had partially positive results meaning that the application showed significant efficacy in some measured outcomes but not all; and 8% applications had non-significant results. CONCLUSIONS Overall the applications included had good levels of acceptability, while only half had their efficacy evaluated. In those evaluations, the endpoints used are mostly related to reported behavior change and knowledge improvement, which is common for evaluations of health promotion programs. In the future, it is inevitable that more health applications will be created. Thus, it is essential that applications that claim to have a public health objective undergo a rigorous evaluation of their acceptability, efficacy and actual use. Indicators of outcomes, such as changes in health status, or access to care should be reported in future studies, beyond only reported changes in behavior and knowledge. This systematic review has helped us note the characteristics associated with improved acceptability and efficacy, which can be helpful for the development of future applications.


This article is an analysis of scientific publications that reflect the experience of using autologous plateletrich plasma in patients with androgenic alopecia (AGA), a multifactorial genetically predisposed disease caused by the influence of exogenous or endogenous triggers responsible for the clinical manifestations of pathology. Attention to this topic is due to the significant prevalence of AGA, as well as unsatisfactory results in achieving a positive therapeutic effect. Positive results were obtained during the 12 clinical studies among the conducted ones, no positive dynamics were observed in the end of other 2 studies. It can be noted that different methods and parameters of centrifugation were used to perform these experiments: PRP used differ or PRP activators were not used at all, variations were observed in methods for evaluating the obtained results, the multiplicity of procedures and intervals between them, the procedure technique (using a mezoroller, anesthetics, injections, etc.). Studies with a negative result were characterized by the smallest number of procedures performed (1 or 2 procedures), and methods for evaluating the results cannot be called sufficiently reliable (a magnifying glass). It is obvious that the use of PRP has a positive effect on the state of AGA and can be used with approved methods of this disease treatment. However, the published results of only a small number of clinical trials on the effectiveness of PRP for hair growth cannot be considered objective. In addition, there is no published agreed protocol for the standard use of PRP, and the use of growth factors and stimulants in the expression of their genes still requires comparative evaluation with preparations approved for the treatment of hair. Thus, the method of PRP using can be considered as a method of treating AGA, however, it is necessary to continue research for further study and standardization of this technique.


2018 ◽  
pp. 199-204
Author(s):  
Gizele da Silva Lima ◽  
Iris Milleyde da Silva Laurentino ◽  
Vânia Nazaré da Costa Silva ◽  
Antonio Flaudiano Bem Leite ◽  
Marcelo Moraes Valença ◽  
...  

Introduction: Several studies present evidence that headache is a symptom often associated with systemic arterial hypertension (SAH) and it may contribute to a greater potential for the development of these diseases, including the risks of more serious damages, such as stroke). Objective: To identify in the existing scientific publications the relation between migraine, systemic arterial hypertension and secondary outcome of cerebrovascular accident. Methodological procedures: This is an integrative literature review from 2014 to 2018, in the bibliographic databases of Latin Literature (LILACS) and the Medical Literature Analysis and Retrieval System Online (MEDLINE /PUBMED) conducted in April 2019. From 50 identified records, considering the selected descriptors, through selection and eligibility procedures according to the proposed inclusion and exclusion criteria, 04 articles were selected. The PRISMA tool (Preferred Reporting Items for Systematic Reviews and Meta-analyzes) was used as a guideline in the writing of the integrated review. Results: 50% of the analyzed studies directed the objectives for the investigation of the association between migraine and cardiovascular disease. The others, prioritized as objective the evaluation of migraine as a risk factor for stroke. The findings of the studies analyzed in full confirm the presence of the association of migraine with systemic arterial hypertension and stroke. Of these, only one presented no significance in the statistical model, when migraine was generally included for the risk of stroke, but when migraine with aura was inserted, it showed positive results. Conclusion: Migraine is directly associated with cardiovascular diseases and can have a significant impact, both for the patients' disability and for the public health policy, which needs to improve strategies for monitoring and preventing negative outcomes in the long term.


1990 ◽  
Vol 29 (05) ◽  
pp. 204-209
Author(s):  
B. Ugarković ◽  
D. Ivančević ◽  
D. Babić ◽  
Ž. Babić

A method is presented which combines gastro-oesophageal reflux quantification and oesophageal transit measurement so as to differentiate true reflux from residual oesophageal activity. A group of 33 subjects with gastro-oesophageal reflux symptoms and endoscopically confirmed reflux oesophagitis and a group of 21 asymptomatic subjects with normal oesophageal, gastric and duodenal endoscopic findings were examined. The subjects were given 37 MBq 99mTc-Sn-colloid in saline orally and then scintiscanned dynamically. The gastro-oesophageal quantification was done after transit measurement and after the oesophageal time activity (to detect residual oesophageal activity) reached its minimum. The difference in the reflux indices between the two groups was highly significant. In low-grade oesophagitis measured reflux was lower than in higher grades of disease. Only 4.7% false-positive results were observed with a specificity of 95%, indicating that this method may be superior to methods published earlier.


1974 ◽  
Vol 31 (02) ◽  
pp. 273-278
Author(s):  
Kenneth K Wu ◽  
John C Hoak ◽  
Robert W Barnes ◽  
Stuart L Frankel

SummaryIn order to evaluate its daily variability and reliability, impedance phlebography was performed daily or on alternate days on 61 patients with deep vein thrombosis, of whom 47 also had 125I-fibrinogen uptake tests and 22 had radiographic venography. The results showed that impedance phlebography was highly variable and poorly reliable. False positive results were noted in 8 limbs (18%) and false negative results in 3 limbs (7%). Despite its being simple, rapid and noninvasive, its clinical usefulness is doubtful when performed according to the original method.


Sign in / Sign up

Export Citation Format

Share Document