scholarly journals The Effect of Rate Control on Quality of Life in Patients With Permanent Atrial Fibrillation

2011 ◽  
Vol 58 (17) ◽  
pp. 1795-1803 ◽  
Author(s):  
Hessel F. Groenveld ◽  
Harry J.G.M. Crijns ◽  
Maarten P. Van den Berg ◽  
Eric Van Sonderen ◽  
A. Marco Alings ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Rate Control ◽  
Permanent Atrial Fibrillation

scholarly journals Rate Control and Quality of Life in Patients With Permanent Atrial Fibrillation

2006 ◽  
Vol 70 (8) ◽  
pp. 965-970 ◽  
Author(s):  
Takayuki Tsuneda ◽  
Takeshi Yamashita ◽  
Masatake Fukunami ◽  
Koichiro Kumagai ◽  
Shin-ichi Niwano ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Rate Control ◽  
Permanent Atrial Fibrillation

scholarly journals Sex-related differences in risk factors, outcome, and quality of life in patients with permanent atrial fibrillation: results from the RACE II study

EP Europace ◽  
2019 ◽  
Vol 22 (11) ◽  
pp. 1619-1627 ◽  
Author(s):  
Mariëlle Kloosterman ◽  
Harry J G M Crijns ◽  
Bart A Mulder ◽  
Hessel F Groenveld ◽  
Dirk J Van Veldhuisen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Heart Failure ◽  
Atrial Fibrillation ◽  
Sex Differences ◽  
Rate Control ◽  
Cardiovascular Events ◽  
Event Rate ◽  
Permanent Atrial Fibrillation

Abstract Aims Atrial fibrillation (AF) risk factors translate into disease progression. Whether this affects women and men differently is unclear. We aimed to investigate sex differences in risk factors, outcome, and quality of life (QoL) in permanent AF patients. Methods and results The Rate Control Efficacy in Permanent Atrial Fibrillation (RACE II) randomized 614 patients, 211 women and 403 men, to lenient or strict rate control. In this post hoc analysis risk factors, cardiovascular events during 3-year follow-up (cardiovascular death, heart failure hospitalization, stroke, systemic embolism, bleeding, and life-threatening arrhythmic events), outcome parameters, and QoL were compared between the sexes. Women were older (71 ± 7 vs. 66 ± 8 years, P < 0.001), had more hypertension (70 vs. 57%, P = 0.002), and heart failure with preserved ejection fraction (36 vs. 17%, P < 0.001), but less coronary artery disease (13 vs. 21%, P = 0.02). Women had more risk factors (3.7 ± 1.2 vs. 2.9 ± 1.4, P < 0.001) Cardiovascular events occurred in 46 (22%) women and 59 (15%) men (P = 0.03). Women had a 1.52 times [95% confidence interval (CI) 1.03–2.24] higher yearly cardiovascular event-rate [8.2% (6.0–10.9) vs. 5.4% (4.1–6.9), P = 0.03], but this was no longer significant after adjusting for the number of underlying risk factors. Women had reduced QoL, irrespective of age and heart rate but negatively influenced by their risk factors. Conclusion In this permanent AF population, women had more accumulation of AF risk factors than men. The observed higher cardiovascular event rate in women was no longer significant after adjusting for the number of risk factors. Further, QoL was negatively influenced by the higher number of risk factors in women. This suggests that sex differences may be driven by the greater risk factor burden in women.

scholarly journals Lenient rate control versus strict rate control for atrial fibrillation: a protocol for the Danish Atrial Fibrillation (DanAF) randomised clinical trial

BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e044744
Author(s):  
Joshua Buron Feinberg ◽  
Michael Hecht Olsen ◽  
Axel Brandes ◽  
llan Raymond ◽  
Walter Bjørn Nielsen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Clinical Trial ◽  
Control Strategy ◽  
Rate Control ◽  
Randomised Clinical Trial ◽  
Component Score ◽  
Permanent Atrial Fibrillation ◽  
Sf 36

IntroductionAtrial fibrillation is the most common heart arrhythmia with a prevalence of approximately 2% in the western world. Atrial fibrillation is associated with an increased risk of death and morbidity. In many patients, a rate control strategy is recommended. The optimal heart rate target is disputed despite the results of the the RAte Control Efficacy in permanent atrial fibrillation: a comparison between lenient vs strict rate control II (RACE II) trial.Our primary objective will be to investigate the effect of lenient rate control strategy (<110 beats per minute (bpm) at rest) compared with strict rate control strategy (<80 bpm at rest) on quality of life in patients with persistent or permanent atrial fibrillation.Methods and analysisWe plan a two-group, superiority randomised clinical trial. 350 outpatients with persistent or permanent atrial fibrillation will be recruited from four hospitals, across three regions in Denmark. Participants will be randomised 1:1 to a lenient medical rate control strategy (<110 bpm at rest) or a strict medical rate control strategy (<80 bpm at rest). The recruitment phase is planned to be 2 years with 3 years of follow-up. Recruitment is expected to start in January 2021. The primary outcome will be quality of life using the Short Form-36 (SF-36) questionnaire (physical component score). Secondary outcomes will be days alive outside hospital, symptom control using the Atrial Fibrillation Effect on Quality of Life, quality of life using the SF-36 questionnaire (mental component score) and serious adverse events. The primary assessment time point for all outcomes will be 1 year after randomisation.Ethics and disseminationEthics approval was obtained through the ethics committee in Region Zealand. The design and findings will be published in peer-reviewed journals as well as be made available on ClinicalTrials.gov.Trial registration numberNCT04542785.

High-intensity interval training improves cardiovascular health, exercise capacity, and quality of life in permanent atrial fibrillation: a case study

2015 ◽  
Vol 40 (12) ◽  
pp. 1321-1323 ◽  
Author(s):  
Jennifer L. Reed ◽  
Pablo B. Nery ◽  
David H. Birnie ◽  
Heather E. Tulloch ◽  
Andrew L. Pipe
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
High Intensity ◽  
Cardiovascular Health ◽  
Treatment Options ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Permanent Atrial Fibrillation ◽  
High Intensity Interval

Persons with permanent atrial fibrillation experience reduced exercise tolerance, weight gain, and an associated decline in overall health. We report on a 74-year-old man with permanent atrial fibrillation who underwent a 10-week high-intensity interval training program. Substantial improvements in heart rate, blood pressure, aerobic and functional capacity, and quality of life were observed. These are desirable as these patients are not candidates for other treatment options and more effective therapies for the treatment of atrial fibrillation are needed.

scholarly journals Influence of heart rate control on exercise capacity and quality of life in patients with permanent atrial fibrillation

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Fei She ◽  
Yuan Ma ◽  
Yi Li ◽  
Lei Li ◽  
Weixian Xu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Heart Rate ◽  
Exercise Capacity ◽  
Rate Control ◽  
Short Form ◽  
Linear Regression Analysis ◽  
Control Group ◽  
Cardiopulmonary Exercise

Abstract Background The optimal level of heart rate (HR) control in patients with atrial fibrillation (AF) is unknown. To assess the effect of rate control on cardiopulmonary exercise capacity and quality of life (QoL) in permanent AF. Methods One hundred forty-three patients with permanent AF were enrolled in this study. All patients received rate control medications and were followed up for 1 year. After 1-year therapy, the exercise capacity and QoL were evaluated by cardiopulmonary exercise testing (CPET) and 36-item Short-Form Health Survey, respectively. Data were compared by dividing the patients according to the following criteria: (1) whether the resting HR was ≤80 or > 80 bpm; (2) whether the exercise HR during moderate exercises on CPET was ≤110 or > 110 bpm; and (3) whether the resting HR was ≤80 bpm and exercise HR was ≤110 bpm. Results No significant differences in peak oxygen uptake, peak metabolic equivalent, and anaerobic threshold were found between the strict control and lenient control groups. Both physical component summary (PCS) and mental component summary (MCS) were significantly higher for the strict rate control group than for the lenient control group. The single-factor correlation analysis revealed a negative correlation between resting HR and both PCS and MCS. The multivariable linear regression analysis indicated that both exercise HR and duration of AF linearly correlated with PCS and MCS. Conclusions Therefore, in patients with permanent AF, exercise capacity may not be affected by the stringency of rate control, and strict rate control may be associated with better QoL.

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