scholarly journals GW29-e1382 Association Between Various Glycemic Markers and the Prevalence of Diffuse Coronary Artery Lesion and adverse prognosis in NSTE-ACS patients with Diabetes Mellitus

2018 ◽  
Vol 72 (16) ◽  
pp. C114
Author(s):  
Qi Zhao ◽  
Tingyu Zhang ◽  
Ji Huang ◽  
Yue Ma ◽  
Xuejian Hou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery ◽  
Coronary Artery Lesion ◽  
Patients With Diabetes ◽  
Glycemic Markers

Features of diabetes mellitus in very elderly patients

2019 ◽  
Vol 1 (9) ◽  
pp. 13-19
Author(s):  
S. V. Topolyanskaya ◽  
T. M. Kolontai ◽  
O. N. Vaculenko ◽  
L. I. Dvoretski
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Elderly Patients ◽  
Very Elderly ◽  
Younger Patients ◽  
Patients With Diabetes ◽  
Artery Disease

Modern concepts about features of diabetes mellitus in very elderly patients are described in the article. Special attention to the therapeutic methods of management of very elderly patients with diabetes mellitus has been devoted. The results of diabetes mellitus study in patients with coronary artery disease older than 75 years in comparison with younger patients are presented.

Prognostic value of gamma-glutamyl transferase in patients with diabetes mellitus and coronary artery disease

2016 ◽  
Vol 49 (15) ◽  
pp. 1127-1132 ◽  
Author(s):  
Gjin Ndrepepa ◽  
Roisin Colleran ◽  
Anke Luttert ◽  
Siegmund Braun ◽  
Salvatore Cassese ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Prognostic Value ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Patients With Diabetes ◽  
Artery Disease ◽  
Glutamyl Transferase

Abstract 13887: Cardiac Troponin I and Bnp for Predicting Zero Agatston Score in Patients With Diabetes Mellitus

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Theo Pezel ◽  
Jean Guillaume DILLINGER ◽  
Guillaume Bonnet ◽  
Tiphaine Vidal Trecan ◽  
Anouk Asselin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Multivariate Model ◽  
Cardiac Troponin I ◽  
Agatston Score ◽  
Diabetic Patients ◽  
Nested Models ◽  
Patients With Diabetes

Introduction: Coronary artery calcifications (CAC) Agatston score has shown an excellent prognostic value and particularly in diabetic patients, with a very low rate of cardiovascular (CV) events in patients with zero CAC score. Recent studies have suggested that high-sensitive cardiac troponin I (hs-cTnI) and brain natriuretic peptide (BNP) may be useful to detect subclinical atherosclerosis. Hypothesis: To assess the predictive value of hs-cTnI and BNP to predict zero CAC score in diabetic patients. Methods: Between 2015 and 2019, CAC score was performed in consecutive patients with diabetes mellitus. Patients with symptoms, coronary artery disease or atrial fibrillation were excluded. Within 24h from CT examination, blood samples were taken to measure hs-cTnI and BNP. The relationship between hs-cTnI/BNP concentrations and zero CAC score was evaluated using univariate and multivariate binomial models, and nested models associated with Chi-squared test of independence. Results: Among 844 diabetic patients (61±7 years, 57% men, duration of diabetes 18 years), 35% had zero CAC score, 30% a score from 1-100, 19% from 101-400, and 16% >400. Hs-cTnI/BNP were associated with zero CAC score (OR 2.63, 95%CI[1.51-5.01]; p<0.001; OR 1.09, 95%CI[1.01-1.22]; p=0.03 respectively). In multivariate analysis, hs-cTnI/BNP were associated with zero CAC score (OR 2.38, 95%CI[1.51-4.76]; p=0.009; OR 1.18, 95%CI[1.07-1.32]; p=0.001 respectively). Among 77 variables, the multivariate model including age, gender, smoking, dyslipidaemia, duration of the diabetes, hypertension, diabetic neuropathy, hs-cTnI and BNP significantly discriminated the zero CAC score (AUC=0.81; p<0.001). In nested models, both hs-cTnI and BNP brought information to this multivariate model to predict zero CAC score (p<0.001). Conclusions: Biomarkers hs-cTnI and BNP are associated with zero CAC score in diabetic patients.

Long-term prognosis after percutaneous or surgical revascularization in patients with diabetes mellitus and complex coronary artery disease- a systematic review and meta analysis

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
A Abdul Razzack ◽  
S Mandava ◽  
S Pothuru ◽  
S Adeel Hassan ◽  
D Missael Rocha Castellanos ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Artery Bypass ◽  
Left Main ◽  
All Cause Mortality ◽  
Patients With Diabetes ◽  
Artery Disease

Abstract Funding Acknowledgements Type of funding sources: None. Background-Whether Coronary artery bypass grafting (CABG) confers a survival benefit in patients with diabetes mellitus(DM) and complex coronary artery disease (CAD), including left main CAD and multivessel coronary disease (MVD) after a follow up period ≥ 5 years remains unknown. Methods- Electronic databases (PubMed, Embase, Scopus, Cochrane) were searched from inception to December 12th 2020. Using a generic invariance weighted random effects model, Hazard ratios (HRs) and their 95% confidence intervals (CIs) from individual studies were converted to Log HRs and corresponding standard errors, which were then pooled. The primary outcome of interest was all-cause mortality and major adverse cardiac and cerebrovascular events (MACCE) which was defined as a composite of death, myocardial reinfarction and stroke at ≥ 5 years. Results-A total of 8 studies with 13336 participants(PCI = 6783, CABG = 6553)were included in our analysis. Mean age was 54.6 and 55.3 in the PCI-DES and CABG groups respectively. The 5-yr follow-up outcomes including all-cause mortality (HR 1.37; 95%CI 1.15-1.65; p = 0.0006, I2 = 0)and MACCE (HR 1.48; 95%CI 1.29-1.69; p &lt; 0.00001, I2 = 0) were significantly higher with PCI as compared to CABG. Furthermore, at &gt;5 year follow-up, all-cause mortality (HR 1.35; 95%CI 1.10-1.66; p = 0.004, I2 = 37) and MACCE (HR 1.98; 95%CI 1.85-2.12; p &lt; 0.00001, I2 = 0) had similar outcomes. Conclusion-Amongst patients with DM and Complex CAD ( left main/MVD), CABG was associated with improved long-term mortality and freedom from MACCEs as opposed to PCI-DES. CABG is the preferred revascularization strategy in patients with complex anatomic disease and concurrent diabetes. Abstract Figure.

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