Racial Differences In The Relationship Of Total and Food-Specific IgE To Atopic Dermatitis In Childhood

Background: It is widely acknowledged that food sensitization is related to atopic dermatitis in infants and young children. Objective: To investigate the association of aeroallergen sensitization with increased rates and severity of atopic dermatitis in school children. Methods: We enrolled 576 children (mean age, 9.4 ± 1.8 years) from six elementary schools. Atopic dermatitis was diagnosed by questionnaires, and severity was rated by physical examinations graded by using the Scoring Atopic Dermatitis (SCORAD) index. Skin-prick tests to 22 common allergens (6 aeroallergens and 16 food allergens) were conducted. Logistic and linear regression analyses were performed by using two models: model I adjusted for age, sex, and body mass index z score; and model II adjusted for all model I factors plus asthma and allergic rhinitis. Results: We diagnosed atopic dermatitis in 22.4% (n = 129) of the children, sensitization to foods in 48.3% (n = 278), and sensitization to aeroallergens in 11.3% (n = 65). A total of 26.2% of the children (n = 149) had mild and 6.5% had moderate-to-severe symptoms and signs of atopic dermatitis (n = 37). Atopic dermatitis was associated with sensitization to aeroallergens and eosinophilia (model I), but this risk was no longer significant after additional adjustment for current allergic status (model II). However, the relationship of the total SCORAD score with aeroallergen sensitization and eosinophilia was significant in model I and model II. Conclusion: The severity of atopic dermatitis correlated with the extent of allergic sensitization and eosinophilia. Analysis of our results suggests that more sensitization to dust mites and eosinophilia are related to increased rates and high severity scores of atopic dermatitis.

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Faculty Opinions recommendation of Food Allergy in Infants With Atopic Dermatitis: Limitations of Food-Specific IgE Measurements.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725957563.793512792 ◽

2016 ◽

Author(s):

Carsten Flohr ◽

Teresa Tsakok

Keyword(s):

Atopic Dermatitis ◽

Food Allergy ◽

Specific Ige ◽

Food Specific Ige

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Skin Manifestations of Food Allergy

PEDIATRICS ◽

10.1542/peds.111.s3.1617 ◽

2003 ◽

Vol 111 (Supplement_3) ◽

pp. 1617-1624 ◽

Cited By ~ 3

Author(s):

Wesley Burks

Keyword(s):

Atopic Dermatitis ◽

Food Allergy ◽

Specific Ige ◽

Rational Approach ◽

Severe Atopic Dermatitis ◽

Acute Urticaria ◽

Skin Response ◽

Allergic Skin ◽

Food Challenges ◽

Food Specific Ige

The pediatrician is faced with evaluating a panoply of skin rashes, a subset of which may be induced by food allergy. Acute urticaria is a common manifestation of an allergic skin response to food, but food is rarely a cause of chronic urticaria. Approximately one third of infants/children with moderate to severe atopic dermatitis have food allergy. Although diagnosis of acute urticaria provoked by a food may be evident from a straightforward history and confirmed by diagnostic tests to detect food-specific IgE antibody, determination of the role of food allergy in patients with atopic dermatitis is more difficult and may require additional diagnostic maneuvers, including elimination diets and oral food challenges. The immunopathologic basis of food-allergic disorders that affect the skin and a rational approach to diagnosis and treatment are discussed. Additional disorders that are caused by or mimic ones caused by food allergy are reviewed.

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Antipruritic therapy issues on background of skin xerosis

Medical alphabet ◽

10.33667/2078-5631-2021-27-37-40 ◽

2021 ◽

pp. 37-41

Author(s):

L. S. Kruglova ◽

E. V. Tipaeva

Keyword(s):

Atopic Dermatitis ◽

Clinical Practice ◽

Drug Therapy ◽

Skin Diseases ◽

Transepidermal Water Loss ◽

Topical Drugs ◽

Antipruritic Therapy ◽

Therapeutic Measures ◽

Relationship Of ◽

The Relationship

The relationship of xerosis with various skin diseases is very multifaceted, at the same time, xerosis can be the cause of the onset or aggravation of itching. Modern recommendations for the external treatment of chronic dermatoses, accompanied by xerosis and itching, imply two directions: direct therapeutic measures during an exacerbation and the use of dermatocosmetics adapted to certain symptoms.Material and methods. We observed 26 patients (mean age 38.7 ± 1.9 years with atopic dermatitis, eczema, psoriasis or pruritus, where xerosis was present in the clinical picture and pruritus was noted. All patients used topical drugs in accordance with the nosology, in as an adjuvant therapy – Neotanin Comfort Plus cream.Research results. In atopic dermatitis, the corneometry index increased by an average of 21%, with eczema – by 20%, with psoriasis – by 22%, with skin itching – by 12%. Transepidermal water loss decreased in atopic dermatitis by 19.8%, with eczema – by 22.8%, with psoriasis – by 21.8%, with pruritus – by 18.4% The value of the total BRS index decreased by more than two times.Conclusion. The use of Neotanin Comfort Plus cream in combination with topical drug therapy (GCS, multicomponent drugs) is highly effective and safe in patients with atopic dermatitis, eczema, psoriasis or pruritus, which makes it possible to recommend it for use in wide clinical practice.

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Racial Differences in the Relationship of Glucose Concentrations and Hemoglobin A1c Levels

Annals of Internal Medicine ◽

10.7326/l17-0588 ◽

2018 ◽

Vol 168 (3) ◽

pp. 232

Author(s):

Rajesh Garg

Keyword(s):

Racial Differences ◽

Hemoglobin A1c ◽

Relationship Of ◽

The Relationship

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Ghrelin and Peptide YY in Youth: Are There Race-Related Differences?

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2005-2448 ◽

2006 ◽

Vol 91 (8) ◽

pp. 3117-3122 ◽

Cited By ~ 23

Author(s):

Fida Bacha ◽

Silva A. Arslanian

Keyword(s):

Insulin Sensitivity ◽

Racial Differences ◽

Peptide Yy ◽

Tolerance Test ◽

Oral Glucose ◽

Obesity Prevalence ◽

Satiety Hormone ◽

Design And Methods ◽

Relationship Of ◽

The Relationship

Abstract Objective: Obesity prevalence is higher in African-American (AA) vs. American white (AW) youth. Ghrelin is a “hunger” peptide that is high preprandially and decreases postprandially, and peptide YY (PYY) is a “satiety” hormone increasing after meals. Impaired regulation of ghrelin/PYY may be conducive to obesity. We hypothesized that racial differences in childhood obesity could partly be explained by differences in ghrelin/PYY dynamics. Research Design and Methods: We investigated: 1) ghrelin suppression/PYY elevation in response to an oral glucose tolerance test (OGTT) in AA vs. AW, and 2) the relationship of ghrelin and PYY dynamics to insulin sensitivity. Thirty-three AA and 54 AW prepubertal children underwent an OGTT measuring ghrelin, PYY, glucose, and insulin. Fasting glucose to insulin ratio (GF/IF) was used to assess the relationship of insulin sensitivity to fasting and post-OGTT ghrelin and PYY levels. Results: OGTT-induced suppression in ghrelin (Δ ghrelin) was lower in AA youth. Δ ghrelin correlated with GF/IF (r = 0.47, P < 0.001) and Δ insulin at 30 min (r = −0.47, P < 0.001). In multiple regression analysis, race (P = 0.013) and GF/IF (P = 0.004) contributed independently to the variance in Δ ghrelin (R2 = 0.28, P < 0.001). Fasting and post-OGTT PYY levels were lower in AAs and were not related to insulin sensitivity. Conclusion: The lower suppression of ghrelin in AA, but not the lower PYY levels, correlates with insulinemia and insulin resistance. Less ghrelin suppression and PYY elevation after a meal in black youth could be a potential mechanism of race-related differences in hunger/satiety predisposing to risk of obesity.

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