Faculty Opinions recommendation of Food Allergy in Infants With Atopic Dermatitis: Limitations of Food-Specific IgE Measurements.

Author(s):  
Carsten Flohr ◽  
Teresa Tsakok
PEDIATRICS ◽  
2003 ◽  
Vol 111 (Supplement_3) ◽  
pp. 1617-1624 ◽  
Author(s):  
Wesley Burks

The pediatrician is faced with evaluating a panoply of skin rashes, a subset of which may be induced by food allergy. Acute urticaria is a common manifestation of an allergic skin response to food, but food is rarely a cause of chronic urticaria. Approximately one third of infants/children with moderate to severe atopic dermatitis have food allergy. Although diagnosis of acute urticaria provoked by a food may be evident from a straightforward history and confirmed by diagnostic tests to detect food-specific IgE antibody, determination of the role of food allergy in patients with atopic dermatitis is more difficult and may require additional diagnostic maneuvers, including elimination diets and oral food challenges. The immunopathologic basis of food-allergic disorders that affect the skin and a rational approach to diagnosis and treatment are discussed. Additional disorders that are caused by or mimic ones caused by food allergy are reviewed.


PEDIATRICS ◽  
2015 ◽  
Vol 136 (6) ◽  
pp. e1530-e1538 ◽  
Author(s):  
J. M. Spergel ◽  
M. Boguniewicz ◽  
L. Schneider ◽  
J. M. Hanifin ◽  
A. S. Paller ◽  
...  

Children ◽  
2021 ◽  
Vol 8 (6) ◽  
pp. 497
Author(s):  
Aikaterini Anagnostou

Background: Food allergies are common, affecting 1 in 13 school children in the United States and their prevalence is increasing. Many misconceptions exist with regards to food allergy prevention, diagnosis and management. Objective: The main objective of this review is to address misconceptions with regards to food allergies and discuss the optimal, evidence-based approach for patients who carry this diagnosis. Observations: Common misconceptions in terms of food allergy prevention include beliefs that breastfeeding and delayed introduction of allergenic foods prevent the development of food allergies. In terms of diagnosis, statements such as ‘larger skin prick tests or/and higher levels of food-specific IgE can predict the severity of food-induced allergic reactions’, or ‘Tryptase is always elevated in food-induced anaphylaxis’ are inaccurate. Additionally, egg allergy is not a contraindication for receiving the influenza vaccine, food-allergy related fatalities are rare and peanut oral immunotherapy, despite reported benefits, is not a cure for food allergies. Finally, not all infants with eczema will develop food allergies and epinephrine auto-injectors may unfortunately be both unavailable and underused in food-triggered anaphylaxis. Conclusions and relevance: Healthcare professionals must be familiar with recent evidence in the food allergy field and avoid common misunderstandings that may negatively affect prevention, diagnosis and management of this chronic disease.


2014 ◽  
Vol 133 (2) ◽  
pp. AB196
Author(s):  
Gillian Bassirpour ◽  
Edward M. Zoratti ◽  
Ganesa Wegienka ◽  
Suzanne Havstad ◽  
Alexandra Sitarik ◽  
...  

2016 ◽  
Vol 4 (11) ◽  
pp. 2120-2126 ◽  
Author(s):  
Zahid Shakoor ◽  
◽  
Musibeeh A ◽  
Najd S ◽  
Al-Anazi SaraR ◽  
...  

2020 ◽  
Vol 2 (1) ◽  
pp. 35-38
Author(s):  
Tina Banzon ◽  
Donald Y.M. Leung ◽  
Lynda C. Schneider

Atopic dermatitis (AD), characterized by intense pruritus, eczematous lesions, and a relapsing disease course, is a chronic inflammatory skin disease that affects both children and adults. AD often begins in infancy and is associated with atopic diseases in the personal or family history.1 Environmental factors may trigger AD by affecting the skin barrier and by triggering inflammation. The elicitation of T-helper type 2 cytokines further impairs the epidermal barrier and leads to the penetration of irritants and allergens into the epidermis and thereby perpetuating inflammation. The presence of AD and its severity has been shown to positively correlate with risk of developing food allergy (FA). Children with AD are estimated to be six times more likely to develop FA compared with their healthy peers. It has been reported that nearly 40% of children with moderate-to-severe AD have immunoglobulin E (IgE) mediated FA compared with only 6% in the general population. Although analysis of experimental data has linked skin inflammation in AD to FA, with food challenges reproducing symptoms and avoidance diets improving AD, elimination diets are not known to cure AD and may have unfavorable consequences, such as loss of tolerance, which leads to immediate-type allergy, including anaphylaxis, nutritional deficiencies, growth failure, and reduction of quality of life for the patient and family. Exacerbation of AD can be inaccurately attributed to foods. Individuals with AD are often sensitized to foods with positive testing results, however, able to tolerate the food. In light of widespread ordering and commercial availability of serum specific IgE for FA, testing for FA is recommended only if, from a detailed clinical history, immediate-type allergic symptoms occur with ingestion of food, or in infants with AD who do not improve with optimal skin care.


2010 ◽  
Vol 7 (6) ◽  
pp. 60-63
Author(s):  
A N Pampura ◽  
E E Varlamov

Background. Establish indications for prescription of amino acid formula to infants with atopic dermatitis. Methods. 55 infants with atopic dermatitis and food allergy were enrolled. Allergic examination included skin prick tests and evaluation of specific IgE level. Oral challenge test was performed if necessary. Results. Low efficacy of elimination diet was observed in 16 infants with multiple food protein intolerance. In the issue cluster analysis defined two subgroups. High IgE levels, specific IgE to egg and fish were considered as criterions of the first subgroup. Patients with multiple food protein intolerance and low efficacy to elimination diet received amino acid formula, SCORAD index decreased more than 50% after the first week of treatment. Conclusion. Multiple food protein intolerance is particular form of food allergy. Prescription of amino acid formula is reasonable in this category of patients.


2020 ◽  
Vol 16 (3) ◽  
pp. 301-305
Author(s):  
Jędrzej Przekora ◽  
◽  
Agata Wawrzyniak ◽  
Anna Bujnowska ◽  
Agnieszka Rustecka ◽  
...  

Food allergy is an important problem in the paediatric population. Food products that are most likely to induce allergic reactions include cow’s milk, wheat, peanuts, hen’s eggs, fish and seafood. Food-allergy-related diseases include, among other things, atopic dermatitis, urticaria and asthma. Anaphylactic shock is the most severe form of allergic reaction. Intramuscular adrenalin at a dose of 0.01 mg/kg body weight (maximum dose 0.3–0.5 mg) is the primary treatment for anaphylaxis. An elimination diet is the treatment of choice in food allergy. If symptoms persist despite dietary intervention, extended diagnosis using skin prick tests and/or specific IgE measurements should be performed. We present a clinical case of a 2.5-year-old boy with erythroderma secondary to atopic dermatitis, who was referred to our Department due to the lack of improvement after outpatient treatment. It was found during hospital stay that the symptoms were caused by potato allergens.


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