Interleukin-26 is a Novel Biomarker for Asthma Inflammation Associated with Systemic Inflammation and Lung Function in Obese Asthmatics

2021 ◽  
Vol 147 (2) ◽  
pp. AB54
Author(s):  
Igor Kaidashev ◽  
Yanina Avramenko ◽  
Olga Izmailova ◽  
Oksana Shlykova ◽  
Lawrence Dubuske
Keyword(s):  
Lung Function ◽  
Systemic Inflammation ◽  
Interleukin 26

scholarly journals Systemic inflammation and lung function in young adults

Thorax ◽  
2007 ◽  
Vol 62 (12) ◽  
pp. 1064-1068 ◽  
Author(s):  
R. J Hancox ◽  
R. Poulton ◽  
J. M Greene ◽  
S. Filsell ◽  
C. R McLachlan ◽  
...  
Keyword(s):  
Young Adults ◽  
Lung Function ◽  
Systemic Inflammation

scholarly journals Occupational exposure and markers of genetic damage, systemic inflammation and lung function: a Danish cross-sectional study among air force personnel

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria Helena Guerra Andersen ◽  
Anne Thoustrup Saber ◽  
Marie Frederiksen ◽  
Per Axel Clausen ◽  
Camilla Sandal Sejbaek ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Lung Function ◽  
Air Force ◽  
Systemic Inflammation ◽  
Reference Group ◽  
Exposed Group ◽  
Exposure Level ◽  
Genetic Damage ◽  
Job Functions ◽  
Exposure Levels

AbstractAir force ground crew personnel are potentially exposed to fuels and lubricants, as raw materials, vapours and combustion exhaust emissions, during operation and maintenance of aircrafts. This study investigated exposure levels and biomarkers of effects for employees at a Danish air force military base. We enrolled self-reported healthy and non-smoking employees (n = 79) and grouped them by exposure based on job function, considered to be potentially exposed (aircraft engineers, crew chiefs, fuel operators and munition specialists) or as reference group with minimal occupational exposure (avionics and office workers). We measured exposure levels to polycyclic aromatic hydrocarbons (PAHs) and organophosphate esters (OPEs) by silicone bands and skin wipes (PAHs only) as well as urinary excretion of PAH metabolites (OH-PAHs). Additionally, we assessed exposure levels of ultrafine particles (UFPs) in the breathing zone for specific job functions. As biomarkers of effect, we assessed lung function, plasma levels of acute phase inflammatory markers, and genetic damage levels in peripheral blood cells. Exposure levels of total PAHs, OPEs and OH-PAHs did not differ between exposure groups or job functions, with low correlations between PAHs in different matrices. Among the measured job functions, the UFP levels were higher for the crew chiefs. The exposure level of the PAH fluorene was significantly higher for the exposed group than the reference group (15.9 ± 23.7 ng/g per 24 h vs 5.28 ± 7.87 ng/g per 24 h, p = 0.007), as was the OPE triphenyl phosphate (305 ± 606 vs 19.7 ± 33.8 ng/g per 24 h, p = 0.011). The OPE tris(1,3-dichlor-2-propyl)phosphate had a higher mean in the exposed group (60.7 ± 135 ng/g per 24 h) compared to the reference group (8.89 ± 15.7 ng/g per 24 h) but did not reach significance. No evidence of effects for biomarkers of systemic inflammation, genetic damage or lung function was found. Overall, our biomonitoring study show limited evidence of occupational exposure of air force ground crew personnel to UFPs, PAHs and OPEs. Furthermore, the OH-PAHs and the assessed biomarkers of early biological effects did not differ between exposed and reference groups.

Cross-sectional and longitudinal associations between urinary zinc and lung function among urban adults in China

Thorax ◽  
2020 ◽  
Vol 75 (9) ◽  
pp. 771-779 ◽  
Author(s):  
Min Zhou ◽  
Lili Xiao ◽  
Shijie Yang ◽  
Bin Wang ◽  
Tingming Shi ◽  
...  
Keyword(s):  
Lung Function ◽  
Oxidative Damage ◽  
Systemic Inflammation ◽  
Secretory Protein ◽  
Forced Expiratory Volume ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Mediation Analyses ◽  
Reactive Protein

BackgroundExposure to zinc was suggested to be associated with pulmonary damage, but whether zinc exposure affects lung function remains unclear.ObjectivesTo quantify the association between urinary zinc and lung function and explore the potential mechanisms.MethodsUrinary zinc and lung function were measured in 3917 adults from the Wuhan-Zhuhai cohort and were repeated after 3 years of follow-up. Indicators of systemic inflammation (C reactive protein), lung epithelium integrity (club cell secretory protein-16) and oxidative damage (8-hydroxy-2′-deoxyguanosine and 8-isoprostane) were measured at baseline. Linear mixed models were used to estimate the exposure–response relationship between urinary zinc and lung function. Mediation analyses were conducted to assess mediating roles of inflammation and oxidative damage in above relationships.ResultsEach 1-unit increase in log-transformed urinary zinc values was associated with a 35.72 mL decrease in forced vital capacity (FVC) and a 24.89 mL decrease in forced expiratory volume in 1 s (FEV1) in the baseline analyses. In the follow-up analyses, there was a negative association between urinary zinc and FVC among participants with persistent high urinary zinc levels, with an estimated change of −93.31 mL (95% CI −178.47 to −8.14). Furthermore, urinary zinc was positively associated with restrictive ventilatory impairment. The mediation analyses suggested that C reactive protein mediated 8.62% and 8.71% of the associations of urinary zinc with FVC and FEV1, respectively.ConclusionUrinary zinc was negatively associated with lung function, and the systemic inflammation may be one of the underlying mechanisms.

scholarly journals Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Anouk W. Vaes ◽  
Martijn A. Spruit ◽  
Karel Van Keer ◽  
João Barbosa-Breda ◽  
Emiel F. M. Wouters ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Lung Function ◽  
Systolic Blood Pressure ◽  
Systemic Inflammation ◽  
Pulmonary Rehabilitation ◽  
Functional Outcomes ◽  
Retinal Vessel ◽  
Copd Patients ◽  
Retinal Vessel Diameters

AbstractCardiovascular diseases are frequently present in chronic obstructive pulmonary disease (COPD). Population-based studies found associations between retinal vessel diameters and cardiovascular health, but it is unknown whether this also applies to COPD patients. Therefore, we measured retinal vessel diameters in COPD patients and aimed to determine the association with cardiovascular risk factors, lung function, and functional outcomes. In addition, we investigated whether an exercise-based pulmonary rehabilitation (PR) program would change retinal vessel diameters, as a proxy for improved microvascular health. Demographics and clinical characteristics, including pulmonary function, exercise capacity, blood pressure, blood measurements and level of systemic inflammation were obtained from 246 patients during routine assessment before and after PR. Retinal vessel diameters were measured from digital retinal images. Older age and higher systolic blood pressure were associated with narrower retinal arterioles (β: −0.224; p = 0.042 and β: −0.136; p < 0.001, respectively). Older age, higher systolic blood pressure and lower level of systemic inflammation were associated with narrower retinal venules (β: −0.654; −0.229; and −13.767, respectively; p < 0.05). No associations were found between retinal vessel diameters and lung function parameters or functional outcomes. After PR, no significant changes in retinal venular or arteriolar diameter were found. To conclude, retinal vessel diameters of COPD patients were significantly associated with systolic blood pressure and systemic inflammation, whilst there was no evidence for an association with lung function parameters, functional outcomes or other cardiovascular risk factors. Furthermore, an exercise-based PR program did not affect retinal vessel diameter.

scholarly journals Systemic inflammation and lung function

2011 ◽  
Vol 5 ◽  
pp. 7-8
Author(s):  
I. S. Ólafsdóttir ◽  
T. Gislason ◽  
V. Gudnason ◽  
B. Benediktsdóttir ◽  
I. Ólafsson ◽  
...  
Keyword(s):  
Lung Function ◽  
Systemic Inflammation

Lung function impairment in adult asthma increases the risk of systemic inflammation

2015 ◽  
Author(s):  
Celeste Porsbjerg ◽  
Asger Sverrild ◽  
Katherine Baines ◽  
Peter Gibson ◽  
Vibeke Backer
Keyword(s):  
Lung Function ◽  
Systemic Inflammation ◽  
Adult Asthma ◽  
Function Impairment ◽  
Lung Function Impairment

scholarly journals Hypertension, Systemic Inflammation and Body Weight in Relation to Lung Function Impairment—An Epidemiological Study

2009 ◽  
Vol 6 (4) ◽  
pp. 250-255 ◽  
Author(s):  
Olof Birna Margretardottir ◽  
Sigurdur James Thorleifsson ◽  
Gunnar Gudmundsson ◽  
Isleifur Olafsson ◽  
Bryndis Benediktsdottir ◽  
...  
Keyword(s):  
Body Weight ◽  
Lung Function ◽  
Epidemiological Study ◽  
Systemic Inflammation ◽  
Function Impairment ◽  
Lung Function Impairment

scholarly journals Do Redox Balance and Inflammatory Events Take Place in Mild Bronchiectasis? A Hint to Clinical Implications

2021 ◽  
Vol 10 (19) ◽  
pp. 4534
Author(s):  
Liyun Qin ◽  
Maria Guitart ◽  
Mireia Admetlló ◽  
Sandra Esteban-Cucó ◽  
José María Maiques ◽  
...  
Keyword(s):  
Lung Function ◽  
Exercise Capacity ◽  
Systemic Inflammation ◽  
Bacterial Colonization ◽  
Inflammatory Cells ◽  
Redox Balance ◽  
Acute Phase Reactants ◽  
Therapeutic Implications ◽  
Redox Imbalance ◽  
And Oxidative Stress

We hypothesized that in mild bronchiectasis patients, increased systemic inflammation and redox imbalance may take place and correlate with clinical parameters. In plasma samples from patients with very mild bronchiectasis, inflammatory cells and molecules and redox balance parameters were analyzed. In the patients, lung function and exercise capacity, nutritional status, bacterial colonization, and radiological extension were assessed. Correlations between biological and clinical variables were determined. Compared to healthy controls, levels of acute phase reactants, neutrophils, IgG, IgA, myeloperoxidase, protein oxidation, and GSH increased and lung function and exercise capacity were mildly reduced. GSH levels were even greater in ex-smoker and Pseudomona-colonized patients. Furthermore, radiological extension inversely correlated with airway obstruction and, disease severity, and positively correlated with neutrophil numbers in mild bronchiectasis patients with no nutritional abnormalities. In stable patients with mild bronchiectasis, several important inflammatory and oxidative stress events take place in plasma. These findings suggest that the extension of bronchiectasis probably plays a role in the development of redox imbalance and systemic inflammation in patients with mild bronchiectasis. These results have therapeutic implications in the management of bronchiectasis patients.

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