Cross-sectional and longitudinal associations between urinary zinc and lung function among urban adults in China

Thorax ◽  
2020 ◽  
Vol 75 (9) ◽  
pp. 771-779 ◽  
Author(s):  
Min Zhou ◽  
Lili Xiao ◽  
Shijie Yang ◽  
Bin Wang ◽  
Tingming Shi ◽  
...  
Keyword(s):  
Lung Function ◽  
Oxidative Damage ◽  
Systemic Inflammation ◽  
Secretory Protein ◽  
Forced Expiratory Volume ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Mediation Analyses ◽  
Reactive Protein

BackgroundExposure to zinc was suggested to be associated with pulmonary damage, but whether zinc exposure affects lung function remains unclear.ObjectivesTo quantify the association between urinary zinc and lung function and explore the potential mechanisms.MethodsUrinary zinc and lung function were measured in 3917 adults from the Wuhan-Zhuhai cohort and were repeated after 3 years of follow-up. Indicators of systemic inflammation (C reactive protein), lung epithelium integrity (club cell secretory protein-16) and oxidative damage (8-hydroxy-2′-deoxyguanosine and 8-isoprostane) were measured at baseline. Linear mixed models were used to estimate the exposure–response relationship between urinary zinc and lung function. Mediation analyses were conducted to assess mediating roles of inflammation and oxidative damage in above relationships.ResultsEach 1-unit increase in log-transformed urinary zinc values was associated with a 35.72 mL decrease in forced vital capacity (FVC) and a 24.89 mL decrease in forced expiratory volume in 1 s (FEV1) in the baseline analyses. In the follow-up analyses, there was a negative association between urinary zinc and FVC among participants with persistent high urinary zinc levels, with an estimated change of −93.31 mL (95% CI −178.47 to −8.14). Furthermore, urinary zinc was positively associated with restrictive ventilatory impairment. The mediation analyses suggested that C reactive protein mediated 8.62% and 8.71% of the associations of urinary zinc with FVC and FEV1, respectively.ConclusionUrinary zinc was negatively associated with lung function, and the systemic inflammation may be one of the underlying mechanisms.

P4679Changes in systemic inflammation and endothelial dysfunction after balloon pulmonary angioplasty

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
W Magon ◽  
J Stepniewski ◽  
K Jonas ◽  
M Waligora ◽  
P Podolec ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Serum Concentration ◽  
Systemic Inflammation ◽  
Interleukin 6 ◽  
C Reactive Protein ◽  
Pulmonary Hemodynamics ◽  
Endothelin 1 ◽  
Reactive Protein ◽  
Balloon Pulmonary Angioplasty

Abstract Introduction Pulmonary endarterectomy leads to a decrease in systemic inflammation and improvement in endothelial function in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Balloon pulmonary angioplasty (BPA) improves pulmonary hemodynamics in patients with inoperable CTEPH. Aim To assess changes in systemic inflammation and endothelial dysfunction after a single BPA session and after completion of the treatment. Methods We enrolled consecutive, inoperable CTEPH patients who underwent BPA. Interleukin 6, 10 (IL-6, IL-10), and C-reactive protein (hsCRP) constituted markers of systemic inflammation. Endothelin-1 (ET-1) served as a marker of endothelial dysfunction. Serum concentration of selected markers was assessed in every patient before, 24 hours after the first BPA session and 6 months after completion of the BPA treatment. Age- and sex-matched healthy subjects served as a control group. Results We recruited 20 patients with inoperable CTEPH (6 males [30%]), aged 67 [61–74] years in New York Heart Association class III (n=19 [95%]) and II (n=1 [5%]). BPA treatment was completed with a median of 5 [2–8] BPA sessions per patient. Before starting the treatment CTEPH patients, as compared to controls (n=10), had raised serum level of IL-6 (3.82 [2.75 - 6.03] vs. 2.64 [0.88 - 4.75] pg/ml; p=0.04), hsCRP (2.47 [0.93 - 4.27] vs. 1.23 [0.48–3.21] ng/ml; p=0.02) and ET-1 (2.68 [2.24 - 3.64] vs. 1.47 [1.4 - 1.82] pg/ml; p=0.004). There was no difference in IL-10 level. 24 hours after a BPA session we observed an increased level of IL-6, IL-10 and hsCRP. (Tab.) 6 months after completion of the BPA treatment there was a reduced level of IL-6, hsCRP and ET-1 (Tab.) Table 1. Changes (Δ) in serum concentration of analyzed markers 24 hours after a single BPA session and at 6-months assessment after completion of the BPA treatment (n=20) Initial Δ at 24 hours after single BPA p Δ at 6-months follow-up p ET-1 [pg/ml] 2.68 [2.24; 3.64] −0.2 [−0.5; 0.23] 0.21 −0.47 [−0.96; 0.05] 0.004 IL-6 [pg/ml] 3.82 [2.75; 6.03] 3.67 [1.41; 7.16] 0.008 −0.82 [−3.11; 0.54] 0.04 IL-10 [pg/ml] 0.53 [0.44; 0.58] 0.32 [0.21; 0.87] 0.006 −0.11 [−0.33; 0.14] 0.94 hsCRP [ng/ml] 2.47 [0.93; 4.27] 5.4 [3.96; 10.59] 0.008 −0.36 [−0.94; 0.16] 0.02 ET-1, endothelin 1; hsCRP, C-reactive protein; IL-6, interleukin 6; IL-10, interleukin 10. Conclusions Patients with inoperable CTEPH, as compared to healthy controls, exhibit an increased systemic inflammation and endothelial dysfunction, which both improve after completion of the BPA treatment. At short-term follow-up after single BPA session there is an increase in systemic inflammatory response.

Highly sensitive C-reactive protein levels in Iranian patients with pulmonary complication of sulfur mustard poisoning and its correlation with severity of airway diseases

2009 ◽  
Vol 28 (12) ◽  
pp. 739-745 ◽  
Author(s):  
Davood Attaran ◽  
Shahrzad M Lari ◽  
Mohammad Khajehdaluee ◽  
Hossein Ayatollahi ◽  
Mohammad Towhidi ◽  
...  
Keyword(s):  
Lung Function ◽  
Sulfur Mustard ◽  
Chronic Obstructive ◽  
Case Group ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
The Mean ◽  
Hs Crp

Background: Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due to SM poisoning. Methods: Fifty consecutive SM patients with stable COPD and a mean age 46.3 ± 9.18 years were enrolled in this cross sectional study. Thirty healthy men were selected as controls. Lung function parameters were evaluated. Serum hs-CRP by immunoturbidometry assay was measured in both the patients and controls. Results: In the case group, the mean forced expiratory volume in one second (FEV1) was 2.14 ± 0.76 L (58.98% ± 17.51% predicted). The mean serum hs-CRP was 9.4 ± 6.78 SD and 3.9 ± 1.92 SD mg/L in the cases and controls, respectively, with significant statistical differences (p < .001). There was negative correlation between the serum hs-CRP and FEV1 levels (p = .01). The serum hs-CRP levels were also correlated with Global Initiative for Chronic Obstructive Lung disease (GOLD) stages (r = .45, p < .001). Conclusions: Our findings suggest that the serum hs-CRP level is increased in SM patients with COPD and may have a direct correlation with disease severity. It may then be used as a marker for the severity of COPD in patients with SM poisoning.

scholarly journals Pulmonary Arterial Pressure Response During Exercise in COPD: A Correlation with C-Reactive Protein (hsCRP)

2016 ◽  
Vol 10 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Janos Varga ◽  
Attila Palinkas ◽  
Imre Lajko ◽  
Ildikó Horváth ◽  
Krisztina Boda ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Cardiopulmonary Exercise Testing ◽  
Systolic Pressure ◽  
Forced Expiratory Volume ◽  
Pulmonary Vasculature ◽  
Peak Exercise ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Copd Patients ◽  
Pulmonary Arterial

Background: The non-invasive assessment of pulmonary haemodynamics during exercise provides complementary data for the evaluation of exercise tolerance in patients with COPD. Methods: Exercise echocardiography in the semi-supine position was performed in 27 patients with COPD (C) with a forced expiratory volume in one second (FEV1) of 36±12% predicted and 13 age and gender-matched non-COPD subjects (NC). COPD patients also underwent cardiopulmonary exercise testing with gas exchange detection (CPET). Furthermore, serum high sensitive C-reactive protein (hsCRP), a marker of systemic inflammation, was also measured. Results: The maximal work rate (WRmax) and aerobic capacity (VO2peak) were significantly reduced (WRmax: 77±33 Watt, VO2peak: 50±14 %pred) in COPD. Pulmonary arterial systolic pressure (PAPs) was higher in COPD versus controls both at rest (39±5 vs. 31±2 mmHg, p<0.001), and at peak exercise (72±12 vs. 52±8 mmHg, p<0.001). In 19 (70%) COPD patients, the increase in PAPs was above 22 mmHg. The change in pressure (dPAPs) correlated with hsCRP (r2=0.53, p<0.0001) and forced vital capacity (FVC) (r2=0.18, p<0.001). Conclusion: PAPs at rest and during exercise were significantly higher in COPD patients and correlated with higher hsCRP. This may indicate a role for systemic inflammation and hyperinflation in the pulmonary vasculature in COPD. The study was registered at ClinicalTrials.gov webpage with NCT00949195 registration number.

scholarly journals Obesity Indicators and C-reactive Protein in Indonesian Adults (≥ 40 years): The Indonesian Family Life Survey-5 2014–2015

2020 ◽  
Vol 15 (3) ◽  
Author(s):  
Yeni Mahwati ◽  
Dieta Nurrika
Keyword(s):  
Logistic Regression ◽  
High Risk ◽  
Systemic Inflammation ◽  
Family Life ◽  
Cross Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Indonesian Family Life Survey ◽  
Hs Crp

C-reactive protein (CRP) is the best clinical marker for systemic inflammation. Obesity is associated with increased CRP levels. Systemic inflammation is present before morbidity occurs. Research reveals that the identification of obesity indicators and CRP levels is limited among Indonesians. The present study investigated the associations between obesity indicators (body mass index [BMI], waist circumference [WC], waist-to-hip ratio [WHR], waist-to-height ratio [WHtR]) and CRP levels among Indonesian adults. This cross-sectional study based on Indonesian Family Life Survey-5 2014–2015 was conducted among 3,386 adults (≥ 40 years) living in 13 provinces in Indonesia during the study period. All data were collected in 2014. Multiple logistic regression was used to estimate the odds ratio (ORs) and 95% confidence interval (95% CIs) for hs-CRP levels on obesity indicators by using underweight (BMI) and normal (WC, WHR, and WHtR) as references. Our multivariable logistic regression analyses indicated that respondents with increased WHR (OR: 1.278, 95% CI: 1.005–1.625, P < 0.001) were more likely to have high-risk hs-CRP levels than those with normal WHR. Compared with respondents with normal WHtR, those with increased WHtR were found associated with high-risk hs-CRP levels (OR: 1.980, 95% CI: 1.544–2.541, P < 0.001). Therefore, WHR and WHtR can predict central obesity, which is associated with hs-CRP levels.

Impact of Inflammation on Atrial Fibrillation in patients with Metabolic Syndrome

2021 ◽  
Author(s):  
Ylber Jani ◽  
Kastriot Haxhirexha ◽  
Nehat Baftiu ◽  
Bekim Pocesta ◽  
Atila Rexhepi ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Metabolic Syndrome ◽  
Systemic Inflammation ◽  
Left Atrial ◽  
Cross Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Structural Remodeling ◽  
Reactive Protein ◽  
The Impact

Abstract BACKGROUND: Inflammation have been involved in the pathogenesis of both metabolic syndrome(MS) and atrial fibrillation(AF). The magnitude of elevations in plasma C-reactive protein(CRP) a marker of inflammation, is probably related to atrial structural remodeling and impaired atrial function.In patient with MS,limited data exist regarding impact of plasma levels of inflammatory markers,such as C-reactive protein on the: type of AF and atrial structural and functional remodeling. OBJECTIVE: We set to analyze the impact of degree of systemic inflammation (assessed acrording to CRP levels),on the type of AF,atrial functional and structural remodeling in patients with MS.METHODS: We conducted an multicenter observational cross-sectional study. Recruited were 425 consecutive participants,with MS and AF(paroxysmal, persistent and permanent AF),who attended outpatient visits at 7 general cardiology Health Care Clinics, during 1 calendar year,stratified according CRP-levels:(211 participans with level of CRP ≥3mg/l, and 214, with level of CRP <3mg/l). RESULTS: Permanent type of AF, was more common in participans with CRP-levels ≥3mg/l(54.6% vs.20.5%,p= 0.000),whereas parhoxysmal AF, was more common in participans with CRP-levels of <3 mg/l (9.9% vs.52.3%,p=0.000).Patients who had CRP levels above the cut-off of 3 mg/l,had increased dimension of left atrium{(LA),(4.2±0.3 vs. 3.7±0.2,p=0.000)},higher prevalence of enlargement of LA {defined as left atrial volum index(LAVI) ≥29ml/m2(84.1% vs.48.5%,p=0.002)} and inverse relationship of LA function(defined as left atrial emptying fraction(LAEF <45%, (30.8±3.4 vs.41.9±2.6, p=0.00). There was observed significant association of CRP levels above the cut-off of 3 mg/l and: frequence of persistent AF(OR=8.824,95% CI 1.689-46.100), permanent AF(OR=13.955, 95%CI 2.676 -72.780),increased LA dimension (OR=3.817,95% CI 0.989 -1.544), and decreased LA function.{(expressed by: LAVI >29ml/m2OR=4.014, 95% CI 2.620-6.152),LAEF <45%(OR=3.323,95%CI 2.062 -5.351) and LAVI>29 + LAEF-reduced (OR=3.354,95% CI 1.693 - 6.646)}.CONCLUSIONS: In patients with Metabolic Syndrome,degree of systemic inflammation have significant impact on clinical presentation of Atrial Fibrillation,atrial functional and structural remodeling .

scholarly journals Serum 25-hydroxyvitamin D level, smoking and lung function in adults: the HUNT Study

2015 ◽  
Vol 46 (2) ◽  
pp. 355-363 ◽  
Author(s):  
Tricia L. Larose ◽  
Ben M. Brumpton ◽  
Arnulf Langhammer ◽  
Carlos A. Camargo ◽  
Yue Chen ◽  
...  
Keyword(s):  
Lung Function ◽  
Forced Expiratory Volume ◽  
Lung Function Decline ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Impaired Lung Function ◽  
25 Hydroxyvitamin D ◽  
Hunt Study ◽  
Never Smokers

The association between serum 25-hydroxyvitamin D (25(OH)D) level and lung function changes in the general population remains unclear.We conducted cross-sectional (n=1220) and follow-up (n=869) studies to investigate the interrelationship of serum 25(OH)D, smoking and lung function changes in a random sample of adults from the Nord-Trøndelag Health (HUNT) Study, Norway.Lung function was measured using spirometry and included forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % pred and FEV1/FVC ratio. Multiple linear and logistic regression models estimated the adjusted difference in lung function measures or lung function decline, adjusted odds ratios for impaired lung function or development of impaired lung function and 95% confidence intervals.40% of adults had serum 25(OH)D levels <50 nmol·L−1. Overall, those with a serum 25(OH)D level <50 nmol·L−1 showed worse lung function and increased odds of impaired lung function compared to the ≥50 nmol·L−1 group. These associations tended to be stronger among ever-smokers, including greater decline in FEV1/FVC ratio and greater odds of the development of impaired lung function (FEV1/FVC <70% OR 2.4, 95% CI 1.2–4.9). Associations among never-smokers were null. Results from cross-sectional and follow-up studies were consistent. There were no associations between serum 25(OH)D levels and lung function or lung function changes in never-smokers, whereas significant associations were observed in ever-smokers.

scholarly journals Hair Cortisol, Obesity and the Immune System: Results From a 3 Year Longitudinal Study

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A14-A14
Author(s):  
Eline S van der Valk ◽  
Bibian van der Voorn ◽  
Anand M Iyer ◽  
Mostafa Mohseni ◽  
Pieter J M Leenen ◽  
...  
Keyword(s):  
Leukocyte Count ◽  
Depression And Anxiety ◽  
Hair Cortisol ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Immune Parameters ◽  
Relevant Risk Factor

Abstract Background: Long-term glucocorticoid levels measured in scalp hair (HairGC) are positively correlated to obesity in cross-sectional studies, however it is unclear whether this reflects a state of obesity or an actual maintaining or contributing factor to obesity. Objectives: To investigate whether hair cortisol (HairF) and hair cortisone (HairE) predict changes in body mass index (BMI) and waist circumference (WC) over time, and to assess whether HairGC are linked to immune parameters. Methods: We measured HairGC in 1604 participants of the Netherlands Study of Depression and Anxiety (NESDA), and correlated these to BMI, WC, and immune parameters (interleukin-6 (IL-6), high-sensitive C-reactive protein (CRP), total leukocyte, monocyte and lymphocyte counts and the neutrophil-to-lymphocyte ratio). Also, we assessed whether baseline HairGC predict changes in BMI and WC at the follow-up visit, three years later, and whether immune parameters influenced this correlation. Results: In cross-sectional analyses, HairF and HairE were positively correlated to BMI (β=2.06 and β=2.84kg/m2 respectively) and WC (β=5.36 and β= 8.54cm respectively, all p&lt;0.001). HairF was related to IL-6 (adjusted β=0.15, p&lt;0.05) and leukocyte count (adjusted β=0.57, p&lt;0.01), and HairE to IL-6 (adjusted β=0.21, p&lt;0.05). In the adjusted longitudinal analyses, baseline HairF was associated with a yearly increase in BMI (β=0.58%, p=0.009) and baseline HairE with a yearly increase in WC (β=0.84%, p=0.049). Adjusting for baseline IL-6 or leukocytes did not affect the found associations between GC and WC or BMI change. Conclusions: HairGC levels are related to BMI, WC, IL-6 and leukocytes in cross-sectional analyses. Moreover, chronically higher HairGC may be a relevant risk factor for the development of obesity in the future, although causality is yet to be proven.

scholarly journals Variation in lung function as a marker of adherence to oral and inhaled medication in cystic fibrosis

2017 ◽  
Vol 49 (3) ◽  
pp. 1600987 ◽  
Author(s):  
Helen White ◽  
Nicola Shaw ◽  
Sarah Denman ◽  
Kim Pollard ◽  
Sarah Wynne ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Coefficient Of Variation ◽  
Adult Population ◽  
Medication Possession Ratio ◽  
Forced Expiratory Volume ◽  
Self Report ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Potential Marker

The aim of this study was to characterise adherence in an adult population with cystic fibrosis (CF) and to investigate if variation in lung function was a predictor of adherence to treatment.The adherence of patients aged ≥16 years from an adult CF centre was measured by medication possession ratio (MPR) and self-report. Patients were assigned to one of three adherence categories (<50%, 50 to <80%, ≥80%) by their composite score (MPR). Ordinal regression was used to identify predictors of adherence, including coefficient variation measures for forced expiratory volume in 1 s (FEV1), weight and C-reactive protein concentration, measured from 6 months and 12 months before baseline.MPR data for 106 of 249 patients (mean age 29.8±9.2 years) was retrieved, indicating a mean adherence of 63%. The coefficient of variation for FEV1 was inversely related to adherence and was a univariate predictor of adherence (6 months: OR 0.92, 95% CI 0.87–0.98, p=0.005; 12 months: OR 0.94, 95% CI 0.93–0.99, p=0.03) and remained significant in the final models. The coefficient of variation of weight and C-reactive protein were not predictive of adherence.The coefficient of variation of FEV1 was identified as an objective predictor of adherence. Further evaluation of this potential marker of adherence is now required.

scholarly journals The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Sandra Carrillo-Ibarra ◽  
José Ignacio Cerrillos-Gutiérrez ◽  
Ariadna Escalante-Núñez ◽  
Enrique Rojas-Campos ◽  
Benjamín Gómez-Navarro ◽  
...  
Keyword(s):  
Serum Levels ◽  
Cross Sectional Study ◽  
Graft Dysfunction ◽  
C Reactive Protein ◽  
Sod Activity ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Inflammatory State ◽  
Oxidative State

Objective.To determine the oxidative stress/inflammation behavior in patients with/without acute graft dysfunction (AGD) with Tacrolimus.Methods.Cross-sectional study, in renal transplant (RT) recipients (1-yr follow-up). Patients with AGD and without AGD were included. Serum IL-6, TNF-α, 8-isoprostanes (8-IP), and Nitric Oxide (NO) were determined by ELISA; C-reactive protein (CRP) was determined by nephelometry; lipid peroxidation products (LPO) and superoxide dismutase (SOD) were determined by colorimetry.Results.The AGD presentation was at 5.09 ± 3.07 versus 8.27 ± 3.78 months (p<0.001); CRP >3.19 mg/L was found in 21 versus 19 in the N-AGD group (p=0.83); TNF-α145.53 ± 18.87 pg/mL versus 125.54 ± 15.92 pg/mL in N-AGD (p=0.64); IL-6 2110.69 ± 350.97 pg/mL versus 1933.42 ± 235.38 pg/mL in N-AGD (p=0.13). The LPO were higher in AGD (p=0.014): 4.10 ± 0.69 µM versus 2.41 ± 0.29 µM; also levels of 8-IP were higher in AGD 27.47 ± 9.28 pg/mL versus 8.64 ± 1.54 pg/mL (p=0.01). Serum levels of NO in AGD were lower 138.44 ± 19.20 µmol/L versus 190.57 ± 22.04 µmol/L in N-AGD (p=0.042); antioxidant enzyme SOD activity was significantly diminished in AGD with 9.75 ± 0.52 U/mL versus 11.69 ± 0.55 U/mL in N-AGD (p=0.012).Discussion.Patients with RT present with a similar state of the proinflammatory cytokines whether or not they have AGD. The patients with AGD showed deregulation of the oxidative state with increased LPO and 8-IP and decreased NO and SOD.

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