Child and adolescent clinical features as forerunners of adult-onset major depressive disorder: retrospective evidence from an epidemiological sample

2004 ◽  
Vol 82 (1) ◽  
pp. 9-20 ◽  
Author(s):  
Holly C. Wilcox ◽  
James C. Anthony
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Clinical Features ◽  
Child And Adolescent ◽  
Adult Onset ◽  
Major Depressive ◽  
Epidemiological Sample

Clinical features of the patients with major depressive disorder co-occurring insomnia and hypersomnia symptoms: a report of NSSD study

2021 ◽  
Vol 81 ◽  
pp. 375-381
Author(s):  
Jie Zhao ◽  
Hongmei Liu ◽  
Zhiguo Wu ◽  
Yun Wang ◽  
Tongdan Cao ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Clinical Features ◽  
Major Depressive

Pre-adult versus adult onset major depressive disorder in a naturalistic patient sample: the Leiden Routine Outcome Monitoring Study

2010 ◽  
Vol 41 (7) ◽  
pp. 1407-1417 ◽  
Author(s):  
M. S. van Noorden ◽  
S. E. Minkenberg ◽  
E. J. Giltay ◽  
M. E. den Hollander-Gijsman ◽  
Y. R. van Rood ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Suicide Attempts ◽  
Age Of Onset ◽  
Signs And Symptoms ◽  
Diagnostic Interview ◽  
Adult Onset ◽  
Major Depressive ◽  
Logistic Regression Models ◽  
Outcome Monitoring

BackgroundPre-adult onset of major depressive disorder (MDD) may predict a more severe phenotype of depression. As data from naturalistic psychiatric specialty care settings are scarce, we examined phenotypic differences between pre-adult and adult onset MDD in a large sample of consecutive out-patients.MethodAltogether, 1552 out-patients, mean age 39.2±11.6 years, were diagnosed with current MDD on the Mini-International Neuropsychiatric Interview Plus diagnostic interview as part of the usual diagnostic procedure. A total of 1105 patients (71.2%) had complete data on all variables of interest. Pre-adult onset of MDD was defined as having experienced the signs and symptoms of a first major depressive episode before the age of 18 years. Patients were stratified according to the age at interview (20–40/40–65 years). Correlates of pre-adult onset were analysed using logistic regression models adjusted for age, age squared and gender.ResultsUnivariate analyses showed that pre-adult onset of MDD had a distinct set of demographic (e.g. less frequently living alone) and clinical correlates (more co-morbid DSM-IV – Text Revision diagnoses, more social phobia, more suicidality). In the multivariate model, we found an independent association only for a history of suicide attempts [odds ratio (OR) 3.15, 95% confidence intervals (CI) 1.97–5.05] and current suicidal thoughts (OR 1.81, 95% CI 1.26–2.60) in patients with pre-adult versus adult onset MDD.ConclusionsPre-adult onset of MDD is associated with more suicidality than adult onset MDD. Age of onset of depression is an easy to ascertain characteristic that may help clinicians in weighing suicide risk.

scholarly journals Reduced immunity to measles in adults with major depressive disorder

2018 ◽  
Vol 49 (2) ◽  
pp. 243-249 ◽  
Author(s):  
Bart N. Ford ◽  
Robert H. Yolken ◽  
Faith B. Dickerson ◽  
T. Kent Teague ◽  
Michael R. Irwin ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Age Of Onset ◽  
Solid Phase ◽  
Childhood Vaccination ◽  
Adult Onset ◽  
Major Depressive ◽  
Increased Risk ◽  
The Usa ◽  
Childhood Vaccines

AbstractBackgroundDepression can impair the immunogenicity of vaccine administration in adults. Whereas many vaccinations are administered in childhood, it is not known whether adolescent or adult onset depression is associated with impairments in the maintenance of protection of childhood vaccines. This study tested the hypothesis that individuals with adolescent or adult onset mood disorders would display compromised immunity to measles, a target of childhood vaccination.MethodsIgG antibodies to measles were quantified using a solid phase immunoassay in volunteers with bipolar disorder (BD, n = 64, mean age of onset = 16.6 ± 5.6), currently depressed individuals with major depressive disorder (cMDD, n = 85, mean age of onset = 17.9 ± 7.0), remitted individuals with a history of MDD (rMDD, n = 82, mean age of onset = 19.2 ± 8.6), and non-depressed comparison controls (HC, n = 202), all born after the introduction of the measles vaccine in the USA in 1963.ResultsRelative to HC, both the cMDD group (p = 0.021, adjusted odds ratios (OR) = 0.47, confidence interval (CI) = 0.24–0.90), and the rMDD group (p = 0.038, adjusted OR = 0.50, CI = 0.26–0.97) were less likely to test seropositive for measles. Compared with unmedicated MDD participants, currently medicated MDD participants had a longer lifetime duration of illness and were less likely to test seropositive for measles.ConclusionsIndividuals with adolescent or adult onset MDD are less likely to test seropositive for measles. Because lower IgG titers are associated with increased risk of measles infection, MDD may increase the risk and severity of infection possibly because of impaired maintenance of vaccine-related protection from measles.

Preadult onset vs. adult onset of major depressive disorder: a replication study

2007 ◽  
Vol 115 (3) ◽  
pp. 196-205 ◽  
Author(s):  
S. Zisook ◽  
A. J. Rush ◽  
I. Lesser ◽  
S. R. Wisniewski ◽  
M. Trivedi ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Replication Study ◽  
Adult Onset ◽  
Major Depressive

Clinical features and diagnosis

2012 ◽  
Author(s):  
Raymond W. Lam
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Differential Diagnosis ◽  
Depressive Disorder ◽  
Clinical Features ◽  
Cognitive Symptoms ◽  
Major Depressive ◽  
Low Mood ◽  
Different Types ◽  
Variable Presentation

• Depression is associated with a number of physical, emotional, and cognitive symptoms.• Sub-typing of major depressive disorder has implications for treatment choice and selection.• The differential diagnosis of depression includes bereavement, bipolar disorder, and other medical or substance-induced conditions.Depression is associated with many different types of symptoms which can result to a variable presentation in any given person. The features of depression can be physical (sleep, energy, appetite, libido), emotional (low mood, anxiety, crying) or cognitive (guilt, pessimism, suicidal thoughts). ...

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