Role of depression severity and impulsivity in the relationship between hopelessness and suicidal ideation in patients with major depressive disorder

2015 ◽  
Vol 183 ◽  
pp. 83-89 ◽  
Author(s):  
Yan-yu Wang ◽  
Neng-zhi Jiang ◽  
Eric F.C. Cheung ◽  
Hong-wei Sun ◽  
Raymond C.K. Chan
Keyword(s):  
Major Depressive Disorder ◽  
Suicidal Ideation ◽  
Depressive Disorder ◽  
Depression Severity ◽  
Major Depressive ◽  
The Relationship

scholarly journals Clarifying the role of neuroticism in suicidal ideation and suicide attempt among women with major depressive disorder

2017 ◽  
Vol 47 (13) ◽  
pp. 2334-2344 ◽  
Author(s):  
L. M. Rappaport ◽  
J. Flint ◽  
K. S. Kendler
Keyword(s):  
Major Depressive Disorder ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Depressive Disorder ◽  
Attempted Suicide ◽  
Composite International Diagnostic Interview ◽  
Diagnostic Interview ◽  
Eysenck Personality Questionnaire ◽  
Major Depressive

BackgroundPrior research consistently demonstrates that neuroticism increases risk for suicidal ideation, but the association between neuroticism and suicidal behavior has been inconsistent. Whereas neuroticism is recommended as an endophenotype for suicidality, the association of neuroticism with attempted suicide warrants clarification. In particular, prior research has not distinguished between correlates of attempted suicide, correlates of suicidal ideation, and correlates of comorbid psychopathology.MethodsThe present study used the CONVERGE study, a sample of 5864 women with major depressive disorder (MD) and 5783 women without MD throughout China. Diagnoses, suicidal ideation, and attempted suicide were assessed with the Composite International Diagnostic Interview (CIDI). Neuroticism was assessed with the neuroticism portion of the Eysenck Personality Questionnaire.ResultsResults replicate prior findings on the correlates of suicidal ideation, particularly elevated neuroticism among individuals who report prior suicidal ideation. Moreover, as compared with individuals who reported having experienced only suicidal ideation, neuroticism was associated with decreased likelihood of having attempted suicide.ConclusionsThe association of neuroticism with suicidality is more complicated than has been previously described. Whereas neuroticism increases risk for suicidal ideation, neuroticism may decrease risk for a suicide attempt among individuals with suicidal ideation. These results have implications for the assessment of risk for a suicide attempt among individuals who report suicidal ideation and addresses prior discordant findings by clarifying the association between neuroticism and attempted suicide.

Major depressive disorder in Latin America: The relationship between depression severity, painful somatic symptoms, and quality of life

2005 ◽  
Vol 86 (1) ◽  
pp. 93-98 ◽  
Author(s):  
Rodrigo A. Muñoz ◽  
Margaret E. McBride ◽  
Alan J.M Brnabic ◽  
Carlos J. López ◽  
Luiz Alberto B. Hetem ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Major Depressive Disorder ◽  
Latin America ◽  
Depressive Disorder ◽  
Somatic Symptoms ◽  
Depression Severity ◽  
Major Depressive ◽  
The Relationship

scholarly journals Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression

2021 ◽  
Vol 12 ◽  
Author(s):  
Ines Gallego-Landin ◽  
Alba García-Baos ◽  
Adriana Castro-Zavala ◽  
Olga Valverde
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Cannabinoid Receptors ◽  
Antidepressant Treatment ◽  
Treatment Options ◽  
Endocannabinoid System ◽  
Major Depressive ◽  
Neuropsychiatric Diseases ◽  
The Relationship

Major depressive disorder is a high-impact, debilitating disease and it is currently considered the most prevalent mental illness. It is associated with disability, as well as increased morbidity and mortality. Despite its significant repercussions in our society, its exact pathophysiology remains unclear and therefore, available antidepressant treatment options are limited and, in some cases, ineffective. In the past years, research has focused on the development of a multifactorial theory of depression. Simultaneously, evidence supporting the role of the endocannabinoid system in the neurobiology of neuropsychiatric diseases has emerged. Studies have shown that the endocannabinoid system strongly impacts neurotransmission, and the neuroendocrine and neuroimmune systems, which are known to be dysfunctional in depressive patients. Accordingly, common antidepressants were shown to have a direct impact on the expression of cannabinoid receptors throughout the brain. Therefore, the relationship between the endocannabinoid system and major depressive disorder is worth consideration. Nevertheless, most studies focus on smaller pieces of what is undoubtedly a larger mosaic of interdependent processes. Therefore, the present review summarizes the existing literature regarding the role of the endocannabinoid system in depression aiming to integrate this information into a holistic picture for a better understanding of the relationship between the two.

scholarly journals Role of vitamin D supplementation as adjunctive therapy to escitalopram in patients of major depressive disorder: a 8 week prospective, randomized, interventional, clinical study

2019 ◽  
Vol 8 (8) ◽  
pp. 1713 ◽  
Author(s):  
Shivangna Singh ◽  
Priyamvada Sharma ◽  
Vivek Gautam
Keyword(s):  
Vitamin D ◽  
Major Depressive Disorder ◽  
Clinical Study ◽  
Depressive Disorder ◽  
Vitamin D3 ◽  
Therapeutic Effects ◽  
Depression Severity ◽  
Major Depressive ◽  
Significant Difference

Background: Depression is a major public health problem and occurs in persons of all ages, and is associated with increased morbidity, soaring costs for treatment and reduced productivity and quality of life. Vitamin D is involved in numerous brain processes including neuroimmunomodulation, neuroprotection, neuroplasticity, regulation of neurotrophic factors, and making it biologically plausible to be associated with depression. Aim of the present study is to compare the therapeutic effects of vitamin D given along with escitalopram versus escitalopram given alone in patients with major depressive disorder.  Methods: In this prospective, randomized, interventional clinical study, 60 patients with a diagnosis of major depressive disorder based on ICD-10 criteria were randomly assigned into two groups, one group received 60000IU vitamin D3 weekly plus 10 mg escitalopram OD daily while the other group received escitalopram10 mg OD daily alone for 8 weeks. Depression severity was assessed at 2-week intervals using the 24-item Hamilton Depression Rating Scale (HDRS). Serum 25(OH) vitamin D levels were measured in all the patients at baseline and after intervention.Result: Fifty nine patients completed the trial. Depression severity based on HDRS decreased significantly after intervention, with a significant difference between the two groups. The vitamin D3+escitalopram combination was significantly better than escitalopram alone from the fourth week of treatment. Conclusion: Role of vitamin D in mood disorder and its dietary supplementation is effective as an adjuvant treatment along with SSRIs in depressive disorders, especially in vitamin D deficient patients.

Depression – Let’s Talk - Role of Aashwasan Chikitsa

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Priya Vishal Naik ◽  
Prachi Datta Dalvi U.
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Positive Attitude ◽  
Medical Intervention ◽  
Medical Illness ◽  
Suicidal Tendency ◽  
Major Depressive ◽  
Curative Therapy ◽  
Personal Interaction

The WHO theme for the year 2017 is Depression. Depression (major depressive disorder) is a common and serious medical illness that negatively affects how a person feels, thinks and behaves. Psychotherapy if incorporated along with medications can be of substantial help in depression. It is also called ‘talking therapy’ and is based on personal interaction with the patient. Patients suffering from this disorder do not easily accept it and hence do not feel the need to seek medical intervention or counselling. In this process the symptoms might get aggravated and suicidal tendency (which is the worst effect of this disease) may develop. So it is extremely essential for the patient, family and society to accept, talk, discuss and seek treatment for this disease. This ‘talking therapy’ is of utmost importance in today’s life where concept of privacy is taking its toll. This therapy is mentioned in Ayurveda as Aashwasan Chikitsa. Aashwasan Chikitsa consists of good, pleasing and benevolent thoughts, spiritual ideas, positive attitude, ethics and communication with near ones. So in the treatment of psychological disorders, along with medications counselling therapy plays a very important role. Finally counselling can act as a part of preventive, curative therapy and also aids to avoid recurrence in the patients of depression.

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