The Effect and Mechanism of Exercise Training on Rats with Poststroke Depression Based on the Intestinal Flora

Depression of poststroke depression (PSD) is the most common neuropsychiatric complication after stroke. Patients with PSD had higher mortality, more cognitive disorder, lower quality of life, and higher suicidal tendency. The pathogenesis of PSD mainly involves neurotransmitter inflammatory factors, HPA and BDNF. Enteral dysfunction and intestinal flora disorders caused by stroke can participate in the pathogenesis of PSD through various ways, such as immune, endocrine, and nervous system. In this experiment, we used exercise training as an intervention means to explore the curative effect and possible mechanism by observing the changes of behavior, inflammatory factors, and intestinal flora in rats. The results show that the mechanism of exercise training to improve the depressive behavior of rats may be related to inhibiting the expression of proinflammatory factors and increasing the number of lactic acid bacteria in the intestine.

Effects of Personality Characteristics of Different Genders and Quality of Life Analysis on Risk Factors for Suicide in Depressive Patients

Objective. The study was to explore the roles of personality characteristics of different genders and analyze the risk factors of quality of life (QOL) analysis in suicide among depressive patients. Methods. One hundred and eighty-six depressive patients from January 2018 to March 2019 in the Department of Psychiatry of our hospital were enrolled and divided into Groups A and B considering whether they had a suicidal tendency or not. Among them, 90 in Group A had a suicidal tendency and consisted of 42 males and 48 females, while 96 in Group B had no suicidal tendency and consisted of 44 males and 52 females. Forward and backward selection and then backward selection were performed on all the variables of gender characteristic factors and QOL factors that may cause suicide, on which stepwise regression was finally conducted. Next, univariate logistic regression analysis was first performed to select important variables from the related risk factors that may cause suicide, and then, the multivariate logistic regression model was used to select important independent risk factors. Results and Conclusion. The age of onset, degree of anxiety, moral support, positive mental attitude, and family independence were the independent risk factors that may cause a suicidal tendency for male depressive patients. The age of onset, degree of anxiety, negative life events, moral support, positive mental attitude, family intimacy, psychoticism, and neuroticism were the independent risk factors for female depressive patients. Physiological function, role physical, bodily pain, social function, and emotional role in QOL may be the independent risk factors for a suicidal tendency.

Suicide and Suicidal Tendency in Primary Care Setting; Review Article

Suicide is critical public health problem that primary care physicians potentially can help address given that concerned patients frequently visit them in the weeks and months preceding the successful suicide. This article contemplates issues placing the patient at high risk for successful suicide and clinical valuation techniques available to the primary care physician. Patients identified as being at risk of attractive suicidal or those who have a equal of suicidal ideation or behavior judged apposite for management in the primary care setting should be monitored for risk at regular intervals. It is extremely significant to learn about and try to contextualize the patients' emotions that triggered the present crisis. Nurses can make sure that they have a thorough understanding of the present acuity, and all of the precipitating factors, and can exactly and collaboratively communicate with the caregivers and other involved medical teams.

RISK TAKING BEHAVIOR AS PREDICTORS OF SELF COMPASSION IN UNIVERSITY STUDENTS

The present study was aimed at investigating to what extent self compassion of unıversıty students was predicted by their risk taking behavior sub-dimensions. The sample of study included 658 undergraduate students from different faculties of a public university during the 2018-2019 academic year. In order to collect the data in the study, Self Compassion Scale, Risk Behaviors Scale and Personal Information Form are used. Pearson product-moment correlation coefficient and multiple regression analysis were used in the analysis. The results of the study revealed the highest correlation between self compassion scores and suicidal tendency, which is one of the sub-dimensions of risk-taking behavior. In addition, it was found that together with the sub-dimensions of risk taking behavior, it explained 38.2% of the variance in self-compassion scores and It was found that the variable that most predicted self-compassion was suicidal tendency. Findings were discussed and interpreted in the light of literature.

Study of Comparison of Suicidal Cases in the Lockdown Period During First Wave of COVID-19 with that of Suicidal Cases in the Period before it among Dead Bodies Brought for Autopsy at Nalanda Medical College, Patna - A Record Review

Introduction: The COVID-19 pandemic has affected the entire world, physically, psychologically and socio-economically. It has caused extreme mental stress to not only those infected but also those who had to remain indoors for prolonged period due to lockdown. Aims and Objectives: 1. To study and compare all confirmed suicidal deaths in the first lockdown period upto its peak period (September 2020) with suicidal cases during the previous six months from October 2019 to 24th march 2020. 2. Demographic analysis of suicidal cases with determinants like incidence, sex, & age wise distribution, mode of suicide, any specific causes etc, will be studied & evaluated for any perceptible change from earlier prelockdwn suicidal deaths Materials and Methods: It is retrospective, record review analytical and comparative study based on postmortem examination reports of all cases conducted by all doctors of department of FMT, Nalanda Medical College, Patna who did autopsy during both periods (pre lockdown & post lockdown/unlock) together with study of all police inquests, requisitions (challans), sent by the police investigating officers of concerned cases. Study period- a) 25th march 2020 to September 2020 (lockdown phase). b) October 2019 to 24th march 2020 (Prelockdown phase). Results: Total number of suicides increase from 6.61%in pre-covid period to 8.56% in lockdown period. In the prelockdown phase the cases of hanging were 66.66% but due to poisoning 33.34%. But in the lockdown phase hanging accounted for the 95.45% and poisoning just 4.55%. Conclusions: Lockdown must be needed based, preplanned and financial support to the needy together with behavioural counseling should be undertaken in letter and spirit. There is an urgency to realize the severity of this suicidal tendency.

Relationship of Internalized Transnegativity and Protective Factors With Depression, Anxiety, Non-suicidal Self-Injury and Suicidal Tendency in Trans Populations: A Systematic Review

Discrimination heavily impacts the lives of trans populations and causes adverse mental health outcomes. As stated by the Gender Minority Stress Model self-stigmatization could play an important role in this process. The aim of this systematic review is to investigate whether there is a positive association between self-stigmatization and mental health and to identify mediation factors. Studies which quantitatively investigated the association between internalized transnegativity and selected mental health outcomes (depression, anxiety, non-suicidal self-injury, suicidal tendency) in self-identified trans populations were included. Comprehensive search of 5 large databases in June 2020 and the following screening and selection procedure, performed by two researchers separately, identified 14 studies which met criteria. The relationship to be studied was reported with correlation and/or mediation analysis of cross-sectional data. IT was directly positively associated with depression, anxiety and suicidal tendency in most of the reviewed studies. Data indicates links between self-stigmatization and other general mental health stressors such as rumination and thwarted belongingness. Community connectedness showed to be the strongest protective factor for mental health impairments. These results should be considered in transition counseling. More research is needed to better understand the underlying mechanisms of the GMSM and to address unsolved operationalization and measurement issues.

SUICIDAL TENDENCY AND STRESS

Suicide is the second most common cause of death in young adults worldwide. Suicide is often committed out of despair, or attributed to some underlying mental disorder which includes depression, bipolar disorder, schizophrenia, alcoholism and drug abuse. Financial difficulties, troubles with interpersonal relationships and other desirable situation play a significant role but they are prone to commit suicide, this is very serious issue. Generally it assumes that students who don’t have to face above cited problems except stress. Therefore, the present study aimed to find out the suicidal tendency and stress among college students. For this purpose a total of 100 college students were selected from varies college in ahmedabad city i.e. Arts college (N=50) and commerce college (N=50). The sample included both boys and girls students in equal number. Two scales namely suicidal tendency scale and Stress Scale were administered to all the subjects. Obtained scores were analyzed with help ‘t’ test. Results revealed that significant difference in suicidal tendency and stress observed with respect Arts and Commerce College students. It also found that significant difference in suicidal tendency and stress between boys and girls students of Commerce College. While the significance positive correlation between Suicidal tendency and Stress reveals 0.24.

The Impact of Adverse Childhood Experiences (ACEs) on Suicidal Ideation and Suicide Attempts in an Inpatient Adolescent Sample

Background: Suicidal ideation (SI) and suicide attempts (SAs) among adolescents are a significant public health concern worldwide. The current study extends previous research by exploring the association between adverse childhood experiences (ACEs) and SI and SAs in a sample of adolescent inpatients as well as identifying specific predictors for increased risk of SI and SAs. Methods: Associations between ACE scores and self-reported SI and SAs were explored in a sample of 154 adolescent inpatients via clinical interview and by analyzing the association between cumulative ACE scores and scores on the Suicidal Tendency scale of a larger personality measure. We also tested for independent relationships between 19 ACEs and SI and SAs to determine unique predictors for suicidality. Results: One-way ANOVA analyses revealed that those who attempted suicide reported significantly more ACEs compared to those who did not attempt suicide. Witnessing violence in the home, school, or neighborhood, and experiences of discrimination increased one’s likelihood to attempt suicide by two to threefold, while sexual abuse, neglect, and physical abuse increased this likelihood by three-to-fourfold. Stepwise linear regression analyses demonstrated that emotional abuse, living with someone who had mental health problems or attempted suicide were most associated with elevated Suicidal Tendency scores on a personality measure. Conclusions: Early identification, education and intervention are imperative to limit or eliminate ACEs from occurring. The impact of cumulative as well as specific ACEs on suicide risk should be closely considered as areas for such intervention. Areas for future research include extending to include more diverse populations such as the LGBTQ community as well as more ethnically and racially diverse populations.

Risk factors for suicidal tendency in people with epilepsy in China: a case–control study

People with epilepsy (PWE) have an increased suicide prevalence. This study aimed to identify the risk factors for suicidal tendency among PWE in West China. A nested case–control study was designed in a cohort of patients with epilepsy (n = 2087). In total, 28 variates were calculated. In the univariate analysis, unemployment, low income, seizure frequency, seizure-free time, infectious or structural etiology, levetiracetam or phenobarbital use, anxiety, depression, and stigma were associated with suicidal tendency. A multivariate analysis indicated that unemployment (odds ratio [OR] 5.74, 95% confidence interval [CI] 2.13–15.48), levetiracetam use (OR 2.80, 95%CI 1.11–7.05), depression (C-NDDI-E score ≥ 13; OR 3.21, 95%CI 1.26–8.21), and stigma (SSCI score ≥ 16; OR 6.67, 95%CI 1.80–24.69) were independently associated with suicidal tendency. Conditional inference tree analysis indicated that SSCI and C-NDDI-E scores could effectively identify patients with suicidal tendency. Thus, this study suggests that unemployment, levetiracetam use, depression, and stigma are independent risk factors for suicidal tendency in PWE in China.