A preliminary investigation of the role of slow-wave activity in modulating waking EEG theta as a marker of sleep propensity in major depressive disorder

AbstractBackgroundStudies have demonstrated that decreases in slow-wave activity (SWA) predict decreases in depressive symptoms in those with major depressive disorder (MDD), suggesting that there may be a link between SWA and mood. The aim of the present study was to determine if the consequent change in SWA regulation following a mild homeostatic sleep challenge would predict mood disturbance.MethodsThirty-seven depressed and fifty-nine healthy adults spent three consecutive nights in the sleep laboratory. On the third night, bedtime was delayed by 3 h, as this procedure has been shown to provoke SWA. The Profile of Mood States questionnaire was administered on the morning following the baseline and sleep delay nights to measure mood disturbance.ResultsResults revealed that following sleep delay, a lower delta sleep ratio, indicative of inadequate dissipation of SWA from the first to the second non-rapid eye movement period, predicted increased mood disturbance in only those with MDD.ConclusionsThese data demonstrate that in the first half of the night, individuals with MDD who have less SWA dissipation as a consequence of impaired SWA regulation have greater mood disturbance, and may suggest that appropriate homeostatic regulation of sleep is an important factor in the disorder.

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An Integrated Model of Slow-Wave Activity and Neuroplasticity Impairments in Major Depressive Disorder

Current Psychiatry Reports ◽

10.1007/s11920-019-1013-4 ◽

2019 ◽

Vol 21 (5) ◽

Cited By ~ 4

Author(s):

Jennifer R. Goldschmied ◽

Philip Gehrman

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Slow Wave ◽

Integrated Model ◽

Wave Activity ◽

Slow Wave Activity ◽

Major Depressive

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Altered slow wave activity in major depressive disorder with hypersomnia: A high density EEG pilot study

Psychiatry Research Neuroimaging ◽

10.1016/j.pscychresns.2012.03.001 ◽

2012 ◽

Vol 201 (3) ◽

pp. 240-244 ◽

Cited By ~ 19

Author(s):

David T. Plante ◽

Eric C. Landsness ◽

Michael J. Peterson ◽

Michael R. Goldstein ◽

Tim Wanger ◽

...

Keyword(s):

Major Depressive Disorder ◽

Pilot Study ◽

Depressive Disorder ◽

Slow Wave ◽

Wave Activity ◽

High Density ◽

Slow Wave Activity ◽

Major Depressive

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Sex-related differences in sleep slow wave activity in major depressive disorder: a high-density EEG investigation

BMC Psychiatry ◽

10.1186/1471-244x-12-146 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 36

Author(s):

David T Plante ◽

Eric C Landsness ◽

Michael J Peterson ◽

Michael R Goldstein ◽

Brady A Riedner ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Slow Wave ◽

Wave Activity ◽

High Density ◽

Slow Wave Activity ◽

Major Depressive

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Depression – Let’s Talk - Role of Aashwasan Chikitsa

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v2i3.8234 ◽

2017 ◽

Vol 2 (3) ◽

Author(s):

Priya Vishal Naik ◽

Prachi Datta Dalvi U.

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Positive Attitude ◽

Medical Intervention ◽

Medical Illness ◽

Suicidal Tendency ◽

Major Depressive ◽

Curative Therapy ◽

Personal Interaction

The WHO theme for the year 2017 is Depression. Depression (major depressive disorder) is a common and serious medical illness that negatively affects how a person feels, thinks and behaves. Psychotherapy if incorporated along with medications can be of substantial help in depression. It is also called ‘talking therapy’ and is based on personal interaction with the patient. Patients suffering from this disorder do not easily accept it and hence do not feel the need to seek medical intervention or counselling. In this process the symptoms might get aggravated and suicidal tendency (which is the worst effect of this disease) may develop. So it is extremely essential for the patient, family and society to accept, talk, discuss and seek treatment for this disease. This ‘talking therapy’ is of utmost importance in today’s life where concept of privacy is taking its toll. This therapy is mentioned in Ayurveda as Aashwasan Chikitsa. Aashwasan Chikitsa consists of good, pleasing and benevolent thoughts, spiritual ideas, positive attitude, ethics and communication with near ones. So in the treatment of psychological disorders, along with medications counselling therapy plays a very important role. Finally counselling can act as a part of preventive, curative therapy and also aids to avoid recurrence in the patients of depression.

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The Role of Dynorphin and the Kappa Opioid Receptor in Schizophrenia and Major Depressive Disorder: A Translational Approach

10.1007/164_2020_396 ◽

2020 ◽

Author(s):

Samuel David Clark

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Healthy Volunteers ◽

Opioid Receptor ◽

Clinical Data ◽

Potential Role ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Major Depressive

AbstractThe kappa opioid receptor (KOR) and its endogenous ligands dynorphins (DYN) have been implicated in the development or symptomatology of a variety of neuropsychiatric disorders. This review covers a brief history of the development of KOR agonists and antagonists, their effects in healthy volunteers, and the potential role of DYN/KOR dysfunction in schizophrenia and major depressive disorder from a translational perspective. The potential role of DYN/KOR dysfunction in schizophrenia is based on several lines of evidence. Selective KOR agonists induce affective states in healthy volunteers with similarities to the symptoms of schizophrenia. Studies have shown increased DYN in patients with schizophrenia, although the data have been mixed. Finally, meta-analytic data have shown that opioid antagonists are associated with reductions in the symptoms of schizophrenia. The potential role of DYN/KOR dysfunction in major depressive disorder is also based on a combination of preclinical and clinical data. Selective KOR agonists have shown pro-depressive effects in human volunteers, while selective KOR antagonists have shown robust efficacy in several preclinical models of antidepressant activity. Small studies have shown that nonselective KOR antagonists may have efficacy in treatment-resistant depression. Additionally, recent clinical data have shown that the KOR may be an effective target for treating anhedonia, a finding relevant to both schizophrenia and depression. Finally, recommendations are provided for translating preclinical models for schizophrenia and major depressive disorder into the clinic.

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