Linking peripheral IL-6, IL-1β and hypocretin-1 with cognitive impairment from major depression

2020 ◽  
Vol 277 ◽  
pp. 204-211
Author(s):  
Kangyu Jin ◽  
Jing Lu ◽  
Zhebin Yu ◽  
Zhe Shen ◽  
Haimei Li ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Major Depression ◽  
Hypocretin 1

scholarly journals 332 - Electroconvulsive therapy in older adults with major depression was not associated with cognitive decline during a 15-year follow-up

2020 ◽  
Vol 32 (S1) ◽  
pp. 91-91
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Major Depression ◽  
Cognitive Decline ◽  
Electroconvulsive Therapy ◽  
Antidepressant Treatment ◽  
Community Sample ◽  
Control Group

AUTHORS:Kerstin Johansson, Karolina Thömkvist, Ingmar Skoog and Sacuiu SF* (*presenter)OBJECTIVE:To determine the effects of electroconvulsive therapy (ECT) in major depression in relation to the development of dementia during long-term follow-up.METHOD:In an observational clinical prospective study of consecutive patients 70 years and older diagnosed with major depression at baseline 2000-2004 (n=1090), who were free of dementia and received antidepressant treatment, with or without ECT, we sought to determine if cognitive decline (mild cognitive impairment and dementia) during 15 -year follow-up was associated with receiving ECT at baseline. The control group was selected among the participants in the Gothenburg H70 Birth Cohort Studies matched by age group and sex 1:1.RESULTS:Among patients with affective syndromes 7% received ECT. During follow-up, 157 patients were diagnosed with dementia, equal proportions among those who received ECT (14.5%) and those who did not receive ECT (14.5%). The relation between ECT and cognitive decline remained non-significant irrespective antidepressive medication or presence of mild cognitive impairment at baseline.CONCLUSION:Preliminary results indicate that ECT was not associated with the development of cognitive decline in the long-term in a hospital-based cohort of 70+ year-olds. The results remain to verify against controls from a representative community sample.

scholarly journals Depression, cognitive, and functional outcomes of Problem Adaptation Therapy (PATH) in older adults with major depression and mild cognitive deficits

2020 ◽  
Vol 32 (4) ◽  
pp. 485-493
Author(s):  
Dora Kanellopoulos ◽  
Paul Rosenberg ◽  
Lisa D. Ravdin ◽  
Dalynah Maldonado ◽  
Nimra Jamil ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Treatment Group ◽  
Major Depression ◽  
Rating Scale ◽  
Treatment Options ◽  
Supportive Therapy ◽  
Psychosocial Interventions ◽  
World Health ◽  
Time Interaction

ABSTRACTObjectives:Antidepressants have limited efficacy in older adults with depression and cognitive impairment, and psychosocial interventions for this population have been inadequately investigated. Problem Adaptation Therapy (PATH) is a psychosocial intervention for older adults with major depression, cognitive impairment, and disability.Design:This study tests the efficacy of PATH versus Supportive Therapy for Cognitively Impaired Older Adults (ST-CI) in reducing depression (Montgamery Asberg Depression Rating Scale [MADRS]) and disability (World Health Organization Disability Assessments Schedule-II [WHODAS-II]) and improving cognitive outcomes (Mini Mental State Examination [MMSE]) over 24 weeks (12 weeks of treatment and 12-week post-treatment follow-up).Setting:Participants were recruited through collaborating community agencies of Weill Cornell Institute of Geriatric Psychiatry. Both interventions and all research assessments were conducted at home.Participants:Thirty-five older adults (age ≥ 65 years) with major depression and cognitive impairment no dementia (CIND).Interventions:PATH aims to increase emotion regulation by incorporating a problem-solving approach, teaching compensatory strategies, and inviting caregiver participation. Supportive Therapy aims to facilitate the expression of affect, as well as promote empathy.Measurements:Depression was measured using the MADRS, disability using the WHODAS-II, and cognition using the MMSE.Results:PATH participants showed significantly greater reduction in MADRS total score (7.04 points at 24 weeks, treatment group by time interaction: F[1,24.4] = 7.61, p = 0.0108), greater improvement in MMSE total score (2.30 points at 24 weeks, treatment group by time interaction: F[1,39.8] = 13.31, p = 0.0008), and greater improvement in WHODAS-II total score (2.95 points at 24 weeks, treatment group by time interaction: F[1,89] = 4.93, p = 0.0290) than ST-CI participants over the 24-week period.Conclusions:PATH participants had better depression, cognitive, and disability outcomes than ST-CI participants over 6 months. PATH may provide relief to depressed older adults with CIND who currently have limited treatment options.

Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target

2013 ◽  
Vol 64 ◽  
pp. 337-346 ◽  
Author(s):  
Celia Goeldner ◽  
Theresa M. Ballard ◽  
Frederic Knoflach ◽  
Juergen Wichmann ◽  
Silvia Gatti ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Major Depression ◽  
Therapeutic Target ◽  
Mglu2 Receptor

The screen for cognitive impairment in psychiatry (SCIP) is associated with disease severity and cognitive complaints in major depression

2018 ◽  
Vol 23 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Smadar Valérie Tourjman ◽  
Robert-Paul Juster ◽  
Scot Purdon ◽  
Emmanuel Stip ◽  
Edouard Kouassi ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Major Depression ◽  
Disease Severity ◽  
Cognitive Complaints

The prevalence and recognition of major depression among low-level aged care residents with and without cognitive impairment

2007 ◽  
Vol 11 (1) ◽  
pp. 82-88 ◽  
Author(s):  
T. E. Davison ◽  
M. P. Mccabe ◽  
D. Mellor ◽  
C. Ski ◽  
K. George ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Major Depression ◽  
Aged Care ◽  
Low Level

DSM bereavement exclusion for major depression and objective cognitive impairment

2011 ◽  
Vol 130 (1-2) ◽  
pp. 113-117 ◽  
Author(s):  
Emmanuelle Corruble ◽  
Bruno Falissard ◽  
Philip Gorwood
Keyword(s):  
Cognitive Impairment ◽  
Major Depression

scholarly journals Rewiring of the Serotonin System in Major Depression

2021 ◽  
Vol 12 ◽  
Author(s):  
Faranak Vahid-Ansari ◽  
Paul R. Albert
Keyword(s):  
Mental Illness ◽  
Cognitive Impairment ◽  
Major Depression ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Chronic Treatment ◽  
Brain Regions ◽  
Synaptic Organization ◽  
Serotonin System ◽  
The Brain

Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to innervate many brain regions implicated in the functions. During the development of the brain, as serotonin axons project and innervate brain regions, there is evidence that 5-HT plays key roles in wiring the developing brain, both by modulating 5-HT innervation and by influencing synaptic organization within corticolimbic structures. These actions are mediated by 14 different 5-HT receptors, with region- and cell-specific patterns of expression. More recently, the role of the 5-HT system in synaptic re-organization during adulthood has been suggested. The 5-HT neurons have the unusual capacity to regrow and reinnervate brain regions following insults such as brain injury, chronic stress, or altered development that result in disconnection of the 5-HT system and often cause depression, anxiety, and cognitive impairment. Chronic treatment with antidepressants that amplify 5-HT action, such as selective serotonin reuptake inhibitors (SSRIs), appears to accelerate the rewiring of the 5-HT system by mechanisms that may be critical to the behavioral and cognitive improvements induced in these models. In this review, we survey the possible 5-HT receptor mechanisms that could mediate 5-HT rewiring and assess the evidence that 5-HT-mediated brain rewiring is impacting recovery from mental illness. By amplifying 5-HT-induced rewiring processes using SSRIs and selective 5-HT agonists, more rapid and effective treatments for injury-induced mental illness or cognitive impairment may be achieved.

P01-78 - Cognitive impairment and altered vigilance in treatment resistant major depression

2010 ◽  
Vol 25 ◽  
pp. 299
Author(s):  
D. Neu ◽  
C. Kornreich ◽  
X. Montana ◽  
G. Hoffmann ◽  
O. Sentissi ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Major Depression ◽  
Treatment Resistant
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