Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target

2013 ◽  
Vol 64 ◽  
pp. 337-346 ◽  
Author(s):  
Celia Goeldner ◽  
Theresa M. Ballard ◽  
Frederic Knoflach ◽  
Juergen Wichmann ◽  
Silvia Gatti ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Major Depression ◽  
Therapeutic Target ◽  
Mglu2 Receptor

scholarly journals 332 - Electroconvulsive therapy in older adults with major depression was not associated with cognitive decline during a 15-year follow-up

2020 ◽  
Vol 32 (S1) ◽  
pp. 91-91
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Major Depression ◽  
Cognitive Decline ◽  
Electroconvulsive Therapy ◽  
Antidepressant Treatment ◽  
Community Sample ◽  
Control Group

AUTHORS:Kerstin Johansson, Karolina Thömkvist, Ingmar Skoog and Sacuiu SF* (*presenter)OBJECTIVE:To determine the effects of electroconvulsive therapy (ECT) in major depression in relation to the development of dementia during long-term follow-up.METHOD:In an observational clinical prospective study of consecutive patients 70 years and older diagnosed with major depression at baseline 2000-2004 (n=1090), who were free of dementia and received antidepressant treatment, with or without ECT, we sought to determine if cognitive decline (mild cognitive impairment and dementia) during 15 -year follow-up was associated with receiving ECT at baseline. The control group was selected among the participants in the Gothenburg H70 Birth Cohort Studies matched by age group and sex 1:1.RESULTS:Among patients with affective syndromes 7% received ECT. During follow-up, 157 patients were diagnosed with dementia, equal proportions among those who received ECT (14.5%) and those who did not receive ECT (14.5%). The relation between ECT and cognitive decline remained non-significant irrespective antidepressive medication or presence of mild cognitive impairment at baseline.CONCLUSION:Preliminary results indicate that ECT was not associated with the development of cognitive decline in the long-term in a hospital-based cohort of 70+ year-olds. The results remain to verify against controls from a representative community sample.

Comparison of Cognitive Impairment Associated With Major Depression Following Stroke Versus Traumatic Brain Injury

2002 ◽  
Vol 43 (4) ◽  
pp. 295-301 ◽  
Author(s):  
Amane Tateno ◽  
Yuichi Murata ◽  
Robert G. Robinson
Keyword(s):  
Traumatic Brain Injury ◽  
Cognitive Impairment ◽  
Brain Injury ◽  
Major Depression

scholarly journals Depression, cognitive, and functional outcomes of Problem Adaptation Therapy (PATH) in older adults with major depression and mild cognitive deficits

2020 ◽  
Vol 32 (4) ◽  
pp. 485-493
Author(s):  
Dora Kanellopoulos ◽  
Paul Rosenberg ◽  
Lisa D. Ravdin ◽  
Dalynah Maldonado ◽  
Nimra Jamil ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Treatment Group ◽  
Major Depression ◽  
Rating Scale ◽  
Treatment Options ◽  
Supportive Therapy ◽  
Psychosocial Interventions ◽  
World Health ◽  
Time Interaction

ABSTRACTObjectives:Antidepressants have limited efficacy in older adults with depression and cognitive impairment, and psychosocial interventions for this population have been inadequately investigated. Problem Adaptation Therapy (PATH) is a psychosocial intervention for older adults with major depression, cognitive impairment, and disability.Design:This study tests the efficacy of PATH versus Supportive Therapy for Cognitively Impaired Older Adults (ST-CI) in reducing depression (Montgamery Asberg Depression Rating Scale [MADRS]) and disability (World Health Organization Disability Assessments Schedule-II [WHODAS-II]) and improving cognitive outcomes (Mini Mental State Examination [MMSE]) over 24 weeks (12 weeks of treatment and 12-week post-treatment follow-up).Setting:Participants were recruited through collaborating community agencies of Weill Cornell Institute of Geriatric Psychiatry. Both interventions and all research assessments were conducted at home.Participants:Thirty-five older adults (age ≥ 65 years) with major depression and cognitive impairment no dementia (CIND).Interventions:PATH aims to increase emotion regulation by incorporating a problem-solving approach, teaching compensatory strategies, and inviting caregiver participation. Supportive Therapy aims to facilitate the expression of affect, as well as promote empathy.Measurements:Depression was measured using the MADRS, disability using the WHODAS-II, and cognition using the MMSE.Results:PATH participants showed significantly greater reduction in MADRS total score (7.04 points at 24 weeks, treatment group by time interaction: F[1,24.4] = 7.61, p = 0.0108), greater improvement in MMSE total score (2.30 points at 24 weeks, treatment group by time interaction: F[1,39.8] = 13.31, p = 0.0008), and greater improvement in WHODAS-II total score (2.95 points at 24 weeks, treatment group by time interaction: F[1,89] = 4.93, p = 0.0290) than ST-CI participants over the 24-week period.Conclusions:PATH participants had better depression, cognitive, and disability outcomes than ST-CI participants over 6 months. PATH may provide relief to depressed older adults with CIND who currently have limited treatment options.

The screen for cognitive impairment in psychiatry (SCIP) is associated with disease severity and cognitive complaints in major depression

2018 ◽  
Vol 23 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Smadar Valérie Tourjman ◽  
Robert-Paul Juster ◽  
Scot Purdon ◽  
Emmanuel Stip ◽  
Edouard Kouassi ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Major Depression ◽  
Disease Severity ◽  
Cognitive Complaints

The prevalence and recognition of major depression among low-level aged care residents with and without cognitive impairment

2007 ◽  
Vol 11 (1) ◽  
pp. 82-88 ◽  
Author(s):  
T. E. Davison ◽  
M. P. Mccabe ◽  
D. Mellor ◽  
C. Ski ◽  
K. George ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Major Depression ◽  
Aged Care ◽  
Low Level

Glucose intolerance associating with cognitive impairment and brain diabetes as a therapeutic target in alzheimer’s disease

2017 ◽  
Vol 381 ◽  
pp. 62-63
Author(s):  
Y. Ohyagi ◽  
M. Ohara ◽  
M. Igase ◽  
N. Nakamura ◽  
T. Imamura ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Glucose Intolerance ◽  
Therapeutic Target

DSM bereavement exclusion for major depression and objective cognitive impairment

2011 ◽  
Vol 130 (1-2) ◽  
pp. 113-117 ◽  
Author(s):  
Emmanuelle Corruble ◽  
Bruno Falissard ◽  
Philip Gorwood
Keyword(s):  
Cognitive Impairment ◽  
Major Depression

scholarly journals Rewiring of the Serotonin System in Major Depression

2021 ◽  
Vol 12 ◽  
Author(s):  
Faranak Vahid-Ansari ◽  
Paul R. Albert
Keyword(s):  
Mental Illness ◽  
Cognitive Impairment ◽  
Major Depression ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Chronic Treatment ◽  
Brain Regions ◽  
Synaptic Organization ◽  
Serotonin System ◽  
The Brain

Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to innervate many brain regions implicated in the functions. During the development of the brain, as serotonin axons project and innervate brain regions, there is evidence that 5-HT plays key roles in wiring the developing brain, both by modulating 5-HT innervation and by influencing synaptic organization within corticolimbic structures. These actions are mediated by 14 different 5-HT receptors, with region- and cell-specific patterns of expression. More recently, the role of the 5-HT system in synaptic re-organization during adulthood has been suggested. The 5-HT neurons have the unusual capacity to regrow and reinnervate brain regions following insults such as brain injury, chronic stress, or altered development that result in disconnection of the 5-HT system and often cause depression, anxiety, and cognitive impairment. Chronic treatment with antidepressants that amplify 5-HT action, such as selective serotonin reuptake inhibitors (SSRIs), appears to accelerate the rewiring of the 5-HT system by mechanisms that may be critical to the behavioral and cognitive improvements induced in these models. In this review, we survey the possible 5-HT receptor mechanisms that could mediate 5-HT rewiring and assess the evidence that 5-HT-mediated brain rewiring is impacting recovery from mental illness. By amplifying 5-HT-induced rewiring processes using SSRIs and selective 5-HT agonists, more rapid and effective treatments for injury-induced mental illness or cognitive impairment may be achieved.

Sign in / Sign up

Export Citation Format

Share Document