Adult ADHD, Executive Function, Depressive/Anxiety Symptoms, and Quality of Life: A serial two-mediator model

Abstract Purpose Chemotherapy-induced peripheral neuropathy ((CI)PN) becomes chronic in 30% of cancer patients. Knowledge of predictors of chronic (CI)PN and related impairments in health-related quality of life (HRQoL) is lacking. We examined the role of optimism in chronic (CI)PN severity and associated HRQoL in colorectal cancer (CRC) patients up to two years after diagnosis. Methods CRC patients from a prospective cohort study participated, with sensory peripheral neuropathy (SPN) 1 year after diagnosis (n = 142). Multivariable regression analyses examined the cross-sectional association between optimism (measured by the LOT-R) and SPN severity/HRQoL (measured by the EORTC QLQ-CIPN20 and QLQ-C30), as well as the prospective association in a subsample that completed measures 2 years after diagnosis and still experienced SPN (n = 86). Results At 1-year follow-up, higher optimism was associated with better global HRQoL, and better physical, role, emotional, cognitive, and social functioning (all p < .01). Optimism at year one was also prospectively associated with better global HRQoL (p < .05), and emotional and cognitive functioning at 2-year follow-up (both p < .01). Optimism was not related to self-reported SPN severity. Significant associations were retained when controlling for demographic/clinical variables, and became non-significant after controlling for depressive and anxiety symptoms. Conclusions Optimism and depressive and anxiety symptoms are associated with HRQoL in CRC patients with chronic (CI)PN. Future research may illuminate the mechanisms that these factors share, like the use of (non)adaptive coping styles such as avoidance and acceptance that may inform the design of targeted interventions to help patients to adapt to chronic (CI)PN.

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QOLP-04. PILOT STUDY OF A VIDEOCONFERENCE-BASED PSYCHOLOGICAL INTERVENTION FOR FAMILY CAREGIVERS OF PATIENTS WITH MALIGNANT GLIOMAS

Neuro-Oncology ◽

10.1093/neuonc/noaa215.729 ◽

2020 ◽

Vol 22 (Supplement_2) ◽

pp. ii175-ii175

Author(s):

Deborah Forst ◽

Michelle Mesa ◽

Emilia Kaslow-Zieve ◽

Areej El-Jawahri ◽

Joseph Greer ◽

...

Keyword(s):

Quality Of Life ◽

Self Efficacy ◽

Coping Skills ◽

Malignant Gliomas ◽

Anxiety Symptoms ◽

Structured Interviews ◽

Post Intervention ◽

Clinically Significant ◽

And Coping

Abstract BACKGROUND Caregivers of patients with malignant gliomas experience substantial anxiety symptoms while caring for someone with progressive neurological decline. Yet, interventions to reduce psychological distress and improve quality of life (QoL) in this caregiver population are lacking. METHODS We conducted an open pilot study evaluating feasibility and acceptability of a cognitive behavioral therapy-based intervention for caregivers of patients with malignant gliomas with clinically significant anxiety (Generalized Anxiety Disorder [GAD-7] score ≥ 5). Caregivers participated in six videoconference sessions with a mental health provider. We defined the intervention as feasible if ≥ 70% of eligible caregivers enrolled and ≥ 70% of those enrolled completed ≥ 50% of sessions. We evaluated intervention acceptability in semi-structured interviews. Caregivers completed baseline and post-intervention surveys assessing anxiety and depression symptoms (Hospital Anxiety and Depression Scale), QoL (Caregiver Oncology Quality of Life Questionnaire), caregiving burden (Caregiver Reaction Assessment), self-efficacy (Lewis Cancer Self-Efficacy Scale), and perceived coping skills (Measure of Current Status-Part A). We explored post-intervention changes using paired t-tests. RESULTS We obtained consent from 70.0% (21/30) of caregivers approached, of which 66.7% (14/21) had clinically significant anxiety and thus were eligible to participate (mean age=55.7 years, 64.3% female). Among enrolled caregivers, 71.4% (10/14) completed ≥ 50% of sessions. In semi-structured interviews, all participants found the intervention helpful and valued the ability to participate remotely via videoconference. Among caregivers who completed at least one session, 80.0% (8/10) completed all assessments and were included in analyses. Post-intervention, caregivers reported reduced anxiety symptoms (P=.02) and improved QoL (P=.03) and coping skills (P=.001). We found no significant change in depression, caregiving burden, or self-efficacy. CONCLUSION Our videoconference-based intervention is feasible and acceptable to caregivers. Participants reported significant improvements in anxiety symptoms, quality of life, and coping skills post-intervention, supporting further investigation of the intervention in a randomized controlled trial.

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Anxiety symptoms are the strongest predictor of quality of life in temporal lobe epilepsy

Seizure ◽

10.1016/j.seizure.2021.03.021 ◽

2021 ◽

Author(s):

Ellen Marise Lima ◽

Juliana Gois ◽

Maria Luisa Paiva ◽

Silvia Vincentiis ◽

Sylvie Moschetta ◽

...

Keyword(s):

Quality Of Life ◽

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Anxiety Symptoms

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Quality of Life, Depression, Anxiety Symptoms and Mood State of Wheelchair Athletes and Non-athletes: A Preliminary Study

Frontiers in Psychology ◽

10.3389/fpsyg.2019.01848 ◽

2019 ◽

Vol 10 ◽

Cited By ~ 2

Author(s):

Rodrigo Luiz Vancini ◽

Andressa Amato Gomes ◽

Hudson de Paula-Oliveira ◽

Claudio de Lira ◽

Weverton Rufo-Tavares ◽

...

Keyword(s):

Quality Of Life ◽

Mood State ◽

Anxiety Symptoms ◽

Wheelchair Athletes ◽

Preliminary Study

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Depression and anxiety symptoms in Spanish adult patients with cystic fibrosis: associations with health-related quality of life

General Hospital Psychiatry ◽

10.1016/j.genhosppsych.2016.02.002 ◽

2016 ◽

Vol 40 ◽

pp. 39-46 ◽

Cited By ~ 11

Author(s):

C. Olveira ◽

A. Sole ◽

R.M. Girón ◽

E. Quintana-Gallego ◽

P. Mondejar ◽

...

Keyword(s):

Quality Of Life ◽

Cystic Fibrosis ◽

Anxiety Symptoms ◽

Adult Patients ◽

Depression And Anxiety ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Qualidade de vida e TDAH

Jornal Brasileiro de Psiquiatria ◽

10.1590/s0047-20852007000500011 ◽

2007 ◽

Vol 56 (suppl 1) ◽

pp. 50-52 ◽

Cited By ~ 3

Author(s):

Paulo Mattos ◽

Gabriel Coutinho

Keyword(s):

Quality Of Life ◽

Adult Adhd ◽

Life Questionnaire ◽

Quality Of Life Questionnaire

Portadores adultos de transtorno de déficit de atenção/hiperatividade (TDAH) apresentam comprometimento funcional em diferentes áreas da vida diária que deve ser investigado durante a avaliação clínica. Apesar disso, até recentemente não existiam instrumentos para avaliar o impacto do TDAH na qualidade de vida de adultos portadores. O Adult ADHD Quality of Life Questionnaire (AAQoL) é um instrumento desenhado a partir da sistematização de um conjunto de informações na literatura especializada sobre impacto da doença e desfechos clínicos, bem como opinião de especialistas, de modo a avaliar quantitativamente a qualidade de vida de portadores adultos. O instrumento é subdividido em quatro diferentes subescalas, denominadas produtividade, saúde psicológica, perspectivas de vida e relacionamentos. É discutida a utilidade de um questionário especificamente desenvolvido para avaliar qualidade de vida no TDAH adulto e é apresentado o projeto de validação semântica, validade de constructo e confiabilidade do instrumento em andamento.

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Associations of coping strategies with quality of life (QOL) and mood in patients with acute myeloid leukemia (AML).

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e19012 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e19012-e19012

Author(s):

Matthew J. Reynolds ◽

Mitchell W. Lavoie ◽

Bailey T. Jones ◽

Ashley M. Nelson ◽

Hermioni L. Amonoo ◽

...

Keyword(s):

Quality Of Life ◽

Supportive Care ◽

Coping Strategies ◽

Regression Models ◽

Symptom Burden ◽

Anxiety Symptoms ◽

Hospitalized Patients ◽

Depression Symptoms ◽

Intensive Chemotherapy

e19012 Background: Patients with AML who receive intensive chemotherapy experience immense physical and psychological symptoms, which can result in a substantial deterioration of QOL. As data on the relationship between AML patient coping strategies and patient-reported outcomes are lacking, we aimed to determine the associations between patients’ coping strategies and their quality of life and mood. Methods: We conducted a secondary analysis of cross-sectional data from a multi-site randomized supportive care trial for hospitalized patients diagnosed with AML and receiving intensive chemotherapy. Within 72 hours of initiating chemotherapy, patients completed baseline assessments of QOL (FACT-Leu), anxiety and depression symptoms (HADS), and symptom burden (ESAS). Patients also completed subscales from the Brief Cope to assess baseline use of coping strategies. We created high-order factors (approach-oriented coping vs. avoidant-oriented coping) from the coping subscales and utilized the median split method to identify the proportions of patients with high use of approach and avoidant-oriented coping strategies, respectively. We used linear regression models adjusting for age, gender and diagnosis type (newly diagnosed vs. relapsed/refractory AML) to examine the relationships between patients’ use of coping strategies and their baseline QOL, mood and symptom burden. Results: A total of 160 patients were enrolled in the study (60.0% male; median age 64.4 years [range 19.7-80.1]). Overall, 47.5% (76/160) of patients reported high use of approach-oriented coping strategies, while 38.8% (62/160) reported high use of avoidant-oriented strategies. In regression models, the greater use of approach-oriented coping strategies at baseline was associated with higher baseline QOL (β = 1.33, SE = 0.44, P= 0.003), lower depression (β = -0.28, SE = 0.07, P< 0.001) and anxiety symptoms (β = -0.24, SE = 0.08, P= 0.002), and lower symptom burden (β = -0.96, SE = 0.34, P= 0.006). By contrast, the greater use of avoidant-oriented coping strategies at baseline was associated with lower baseline QOL (β = -4.98, SE = 0.81, P< 0.001), higher depression (β = 0.60, SE = 0.13, P< 0.001) and anxiety symptoms (β = 0.79, SE = 0.14, P< 0.001), and worse symptom burden (β = 2.30, SE = 0.64, P< 0.001). Conclusions: Newly hospitalized patients with AML who utilize approach-oriented coping strategies experience better baseline QOL and mood, and a lower symptom burden. These findings underscore the need for supportive care interventions that promote effective coping in patients with AML, to improve patients’ QOL and reduce their physical and psychological distress.

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