Age-related changes in physiology in individuals with bipolar disorder

ObjectivesAs awareness of bipolar disorder (BD) increases and the world experiences a rapid ageing of the population, the number of people living with BD in later life is expected to rise substantially. There is no current evidence base for the effectiveness of psychological interventions for older adults with BD. This focus group study explored a number of topics to inform the development and delivery of a recovery-focused therapy (RfT) for older adults with BD.DesignA qualitative focus group study.SettingThree focus groups were conducted at a university in the North West of England.ParticipantsEight people took part in the focus groups; six older adults with BD, one carer and one friend.ResultsParticipant’s responses clustered into six themes: (1) health-related and age-related changes in later life, (2) the experience of BD in later life, (3) managing and coping with BD in later life, (4) recovery in later life, (5) seeking helping in the future and (6) adapting RfT for older people.ConclusionsParticipants reported a range of health-related and age-related changes and strategies to manage their BD. Participants held mixed views about using the term ‘recovery’ in later life. Participants were in agreement that certain adaptations were needed for delivering RfT for older adults, based on their experience of living with BD in later life. The data collected as part of the focus groups have led to a number of recommendations for delivering RfT for older adults with BD in a randomised controlled trial (Clinical Trial Registration: ISRCTN13875321).

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Commentary for “Steeper Slope of Age-Related Changes in White Matter Microstructure and Processing Speed in Bipolar Disorder”

American Journal of Geriatric Psychiatry ◽

10.1016/j.jagp.2017.04.002 ◽

2017 ◽

Vol 25 (7) ◽

pp. 753-754

Author(s):

Ariel Gildengers

Keyword(s):

Bipolar Disorder ◽

White Matter ◽

Processing Speed ◽

Age Related ◽

White Matter Microstructure ◽

Age Related Changes

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Age-related changes in the corpus callosum in early-onset bipolar disorder assessed using volumetric and cross-sectional measurements

Brain Imaging and Behavior ◽

10.1007/s11682-010-9101-4 ◽

2010 ◽

Vol 4 (3-4) ◽

pp. 220-231 ◽

Cited By ~ 23

Author(s):

Melissa Lopez-Larson ◽

Janis L. Breeze ◽

David N. Kennedy ◽

Steven M. Hodge ◽

Lena Tang ◽

...

Keyword(s):

Bipolar Disorder ◽

Corpus Callosum ◽

Early Onset ◽

Cross Sectional ◽

Age Related ◽

Age Related Changes

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Age-related changes in physiology in individuals with lifetime bipolar disorder

BJPsych Open ◽

10.1192/bjo.2021.733 ◽

2021 ◽

Vol 7 (S1) ◽

pp. S276-S276

Author(s):

Julian Mutz ◽

Cathryn M Lewis

Keyword(s):

Bone Mineral Density ◽

Blood Pressure ◽

Bipolar Disorder ◽

Body Composition ◽

Lung Function ◽

Grip Strength ◽

Healthy Controls ◽

Mineral Density ◽

Age Related ◽

Age Related Changes

AimsIndividuals with bipolar disorder have reduced life expectancy and may experience accelerated biological ageing. In individuals with lifetime bipolar disorder and healthy controls, we examined differences in age-related changes in physiology.MethodThe UK Biobank study recruited >500,000 participants, aged 37–73 years, between 2006–2010. Generalised additive models were used to examine associations between age and grip strength, cardiovascular function, body composition, lung function and bone mineral density. Analyses were conducted separately in males and females with bipolar disorder compared to healthy controls.ResultAnalytical samples included up to 272,462 adults (mean age = 56.04 years, SD = 8.15; 49.51% females). We found statistically significant differences between bipolar disorder cases and controls for grip strength, blood pressure, pulse rate and body composition, with standardised mean differences of up to -0.238 (95% CI -0.282 to -0.193). There was limited evidence of differences in lung function, heel bone mineral density or arterial stiffness. Case-control differences were most evident for age-related changes in cardiovascular function (in both sexes) and body composition (in females). These differences did not uniformly narrow or widen with age and differed by sex. For example, the difference in systolic blood pressure between male cases and controls was -1.3 mmHg at age 50 and widened to -4.7 mmHg at age 65. Diastolic blood pressure in female cases was 1.2 mmHg higher at age 40 and -1.2 mmHg lower at age 65.ConclusionDifferences in ageing trajectories between bipolar disorder cases and healthy controls were most evident for cardiovascular and body composition measures and differed by sex.

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Age-related changes in physiology in individuals with bipolar disorder

10.1101/2021.03.05.21252987 ◽

2021 ◽

Author(s):

Julian Mutz ◽

Cathryn M. Lewis

Keyword(s):

Bone Mineral Density ◽

Blood Pressure ◽

Bipolar Disorder ◽

Body Composition ◽

Lung Function ◽

Grip Strength ◽

Healthy Controls ◽

Mineral Density ◽

Age Related ◽

Age Related Changes

AbstractObjectivesIndividuals with bipolar disorder have reduced life expectancy and may experience accelerated biological ageing. In individuals with bipolar disorder and healthy controls, we examined differences in age-related changes in physiology.MethodsUK Biobank recruited >500,000 participants, aged 37-73, between 2006–2010. Generalised additive models were used to examine associations between age and grip strength, cardiovascular function, body composition, lung function and bone mineral density. Analyses were conducted separately in males and females with bipolar disorder compared to healthy controls.ResultsAnalytical samples included up to 272,462 adults (mean age = 56.04 years, SD = 8.15; 49.51% females). We found statistically significant differences between bipolar disorder cases and controls for grip strength, blood pressure, pulse rate and body composition, with standardised mean differences of up to −0.238 (95% CI −0.282 to −0.193). There was limited evidence of differences in lung function, heel bone mineral density or arterial stiffness. Case-control differences were most evident for age-related changes in cardiovascular function (in both sexes) and body composition (in females). These differences did not uniformly narrow or widen with age and differed by sex. For example, the difference in systolic blood pressure between male cases and controls was −1.3 mmHg at age 50 and widened to −4.7 mmHg at age 65. Diastolic blood pressure in female cases was 1.2 mmHg higher at age 40 and −1.2 mmHg lower at age 65.ConclusionsDifferences in ageing trajectories between bipolar disorder cases and healthy controls were most evident for cardiovascular and body composition measures and differed by sex.

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