ADHD symptoms and suicide attempts in adults with mood disorders: An observational naturalistic study

To verify the hypothesis that suicide attempts are associated with lower serum cholesterol and triglyceride levels of patients with mood disorders, 26 patients with mood disorders (bipolar disorder and major depressive disorder) were admitted after a medically serious suicide attempt to the emergency department and then hospitalized in the psychiatric unit of the Sant'Andrea Hospital (Rome, Italy). Controls were 87 patients who had not made a recent suicide attempt. Attempters and nonattempters did not differ in the levels of serum cholesterol or triglycerides. Indeed, attempters had nonsignificantly higher serum levels of cholesterol and lower serum levels of triglycerides. The use of biologic indicators such as levels of serum cholesterol and triglycerides in the prediction of suicide risk in mood disorders was not fully supported from this small sample.

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Gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders

Annals of General Psychiatry ◽

10.1186/s12991-020-00318-y ◽

2020 ◽

Vol 19 (1) ◽

Author(s):

Pengshuo Wang ◽

Ran Zhang ◽

Xiaowei Jiang ◽

Shengnan Wei ◽

Fei Wang ◽

...

Keyword(s):

Suicidal Ideation ◽

Mood Disorders ◽

Gray Matter ◽

Suicidal Behavior ◽

Suicide Attempts ◽

Gray Matter Volume ◽

Middle Frontal Gyrus ◽

Left And Right ◽

Magnetic Resonance Imaging Mri ◽

Post Hoc

Abstract Background Mood disorders are severe mental disorders related to increased suicidal behavior. Finding neural features for suicidal behavior, including suicide attempts (SAs) and suicidal ideation (SI), in mood disorders may be helpful in preventing suicidal behavior. Methods Subjects consisted of 70 patients with mood disorders and suicidal behavior, 128 patients with mood disorders without suicidal behavior (mood disorders control, MC), and 145 health control (HC) individuals. All participants underwent structural magnetic resonance imaging (MRI). We used voxel-based morphometry (VBM) techniques to examine gray matter volumes (GMVs). Results Significant differences were found in GMVs of the left and right middle frontal gyrus among the patients with mood disorders and suicidal behavior, MC, and HC. Post hoc comparisons showed significant differences in the GMVs of the above regions across all three groups (P < 0.01): HC > MC > mood disorders with suicidal behavior. However, there were no significant differences in the GMVs of the left and right middle frontal gyrus between the mood disorders with SI and mood disorders with SAs groups. Conclusions These findings provide evidence that abnormal regional GMV in the middle frontal gyrus is associated with suicidal behavior in mood disorders. Further investigation is warranted to determine whether the GMV alterations in mood disorders with SI are different from these in mood disorders with SAs.

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Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts

Journal of Affective Disorders ◽

10.1016/j.jad.2010.09.029 ◽

2011 ◽

Vol 130 (1-2) ◽

pp. 220-225 ◽

Cited By ~ 58

Author(s):

Olaoluwa Okusaga ◽

Robert H. Yolken ◽

Patricia Langenberg ◽

Manana Lapidus ◽

Timothy A. Arling ◽

...

Keyword(s):

Mood Disorders ◽

Suicide Attempts ◽

History Of

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Comorbidity of depression and panic disorder affects suicide attempts in patients with mood disorders

European Neuropsychopharmacology ◽

10.1016/s0924-977x(17)31563-8 ◽

2017 ◽

Vol 27 ◽

pp. S872-S873

Author(s):

V. Liaugaudaite ◽

A. Podlipskyte ◽

N. Mickuviene

Keyword(s):

Panic Disorder ◽

Mood Disorders ◽

Suicide Attempts

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Comorbidity of depression and panic disorder affects suicide attempts in patients with mood disorders

10.26226/morressier.5971be84d462b80290b530fb ◽

2017 ◽

Author(s):

Vilma Liaugaudaite

Keyword(s):

Panic Disorder ◽

Mood Disorders ◽

Suicide Attempts

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The correlation between mood disorders and suicide attempts for the period 2013–2015 at “Mother Teresa” hospital center, Fatbardha Myslimaj, Psychiatrist, Mirela Gokaj, Deana Rama

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.823 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S564-S564

Author(s):

F. Myslimaj ◽

M. Gokaj ◽

D. Rama

Keyword(s):

Mood Disorders ◽

Suicide Attempts ◽

Mental Illnesses ◽

University Hospital ◽

Psychiatric Clinic ◽

Cry For Help ◽

Suicidal Attempts ◽

Competing Interest ◽

The University ◽

Hospital Center

BackgroundPeople, who have tried to commit self-injurers or suicidal attempts, refer symptomatic presence of disorders of humor and numerous problems social as factors precipitant to suicidal thoughts and actions. It is important recognition of the signs of suicide and self-inflicting behavior to help prevent suicide.Materials and methodsThe study includes a period of 3 years of cases hospitalized in the psychiatric clinic UHC, since 2013–2015. The data are taken from the records of admissions at the Psychiatric Clinic at the University Hospital Center. Results are grouped and studied issued by mood disorders, sex, age, place of residence and social status.ResultsThe influence of mood disorders is recently estimated very important in causing suicide attempts compared with other mental illnesses, similar values with contemporary literature.ConclusionsThe majority of suicide attempts do not result in death. Many of these efforts are made in a way that makes salvation possible. These efforts are often a cry for help. Suicide is a social phenomenon different cognitive aspect such as ethical, philosophical, legal, psychiatric, etc. Employees of psycho-social care should be informed about this phenomenon and finding the diagnosis, prevention and treatment of suicidal attempts by persons at risk of suicide.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Affective temperaments, white matter hyperintensities and suicidal risk in patients with mood disorders

European Psychiatry ◽

10.1016/s0924-9338(11)73348-x ◽

2011 ◽

Vol 26 (S2) ◽

pp. 1644-1644

Author(s):

G. Serafini ◽

M. Pompili

Keyword(s):

White Matter ◽

Mood Disorders ◽

Suicidal Behaviour ◽

Affective Disorders ◽

White Matter Hyperintensities ◽

Suicide Attempts ◽

Suicidal Risk ◽

Short Allele ◽

Affective Temperaments ◽

Hyperthymic Temperament

IntroductionPatients with white matter hyperintensities (WMHs) may be at higher risk for affective disorders and suicidal behaviour and affective temperaments may play a significant role in mood disorders.Objectives, aims, methodsRecently, we conducted a study in a sample of 247 patients with major affective disorders consecutively admitted as psychiatric inpatients.ResultsWe found that those with higher dysthymia and lower hyperthymia were more likely to have higher BHS scores, more WMHs, higher MINI suicidal risk, and more recent suicide attempts than patients with higher hyperthymia and lower dysthymia. Previously, we have reported that depressive, cyclothymic, irritable and anxious temperaments are risk factors whereas the hyperthymic temperament is a protective factor for suicidal behaviour, at least for suicide attempters. This is in line with recent genetic studies showing that the short allele of serotonin transporter gene promoter (5-HTTLPR) was significantly related to depressive, cyclothymic, irritable and anxious temperaments (but not to the hyperthymic temperament) and individuals with the short allele of the 5-HTTLPR and major affective disorders have more microstructural white matter abnormalities in specific brain regions.ConclusionsIn subjects with mood disorders, some temperament profiles in addition to WMHs presumably play a critical role in the emergence of hopelessness and suicidal behaviour. Differences among temperament profiles associated with WMHs may be used as biological markers for clinically grouping subjects at higher risk both for the emergence of mood disorders and suicidal behaviour (highly lethal suicide attempts) and this may have relevant implications for treatment.

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Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene–environment study

Molecular Psychiatry ◽

10.1038/mp.2009.19 ◽

2009 ◽

Vol 15 (8) ◽

pp. 831-843 ◽

Cited By ~ 53

Author(s):

J Brezo ◽

A Bureau ◽

C Mérette ◽

V Jomphe ◽

E D Barker ◽

...

Keyword(s):

Mood Disorders ◽

Suicide Attempts ◽

Gene Environment ◽

Environment Study

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Structural brain alterations associated with suicidal thoughts and behaviors in young people: results across 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium

10.1101/2021.09.27.21264068 ◽

2021 ◽

Author(s):

Laura S. van Velzen ◽

Maria R. Dauvermann ◽

Lejla Colic ◽

Luca M. Villa ◽

Hannah S. Savage ◽

...

Keyword(s):

Young People ◽

Mood Disorders ◽

Surface Area ◽

Suicide Attempts ◽

Brain Morphology ◽

Frontal Pole ◽

Suicidal Thoughts ◽

History Of ◽

And Behaviors ◽

Suicidal Thoughts And Behaviors

AbstractObjectiveIdentifying brain differences associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and generating effective approaches to early intervention and prevention. The ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites to examine brain morphology associated with STBs in youth.MethodsFirst, we examined associations among regional brain structure and STBs, which were assessed in six samples of youth with mood disorders, using the Columbia Suicide Severity Rating Scale (C-SSRS; N=577). Second, we combined this sample with a larger sample (total 21 sites) in which STBs were assessed using various instruments. MRI metrics were compared among healthy controls without STBs (HC; N=688), clinical controls without STBs (CC; N=648), and young people with psychiatric diagnoses and current suicidal ideation (N=406). In separate analyses, MRI metrics were compared among HCs (N=335), CCs (N=768), and suicide attempters (N=254).ResultsIn the homogeneous C-SSRS sample, surface area of the frontal pole was lower in young people with mood disorders and history of actual suicide attempts (N=163) than those without (N=394; FDR-p<.001; Cohen’s d=.334). When expanding to more clinically heterogeneous samples, we also found lower surface area of the frontal pole in those with a history of suicide attempts (Cohen’s d=.22).ConclusionsLower frontal pole surface area may represent a vulnerability for a suicide attempt; however, more research is needed to understand the nature of its relationship to suicide risk.

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