Nearly Lethal Resuscitated Suicide Attempters Have No Low Serum Levels of Cholesterol and Triglycerides

To verify the hypothesis that suicide attempts are associated with lower serum cholesterol and triglyceride levels of patients with mood disorders, 26 patients with mood disorders (bipolar disorder and major depressive disorder) were admitted after a medically serious suicide attempt to the emergency department and then hospitalized in the psychiatric unit of the Sant'Andrea Hospital (Rome, Italy). Controls were 87 patients who had not made a recent suicide attempt. Attempters and nonattempters did not differ in the levels of serum cholesterol or triglycerides. Indeed, attempters had nonsignificantly higher serum levels of cholesterol and lower serum levels of triglycerides. The use of biologic indicators such as levels of serum cholesterol and triglycerides in the prediction of suicide risk in mood disorders was not fully supported from this small sample.

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Longitudinal assessment of S100B serum levels and clinical factors in youth patients with mood disorders

Scientific Reports ◽

10.1038/s41598-021-91577-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Aleksandra Rajewska-Rager ◽

Monika Dmitrzak-Weglarz ◽

Pawel Kapelski ◽

Natalia Lepczynska ◽

Joanna Pawlak ◽

...

Keyword(s):

Mood Disorders ◽

Calcium Binding ◽

Clinical Symptoms ◽

Small Sample Size ◽

Serum Levels ◽

Small Sample ◽

Drop Out ◽

Control Group ◽

Longitudinal Assessment ◽

Depressed Group

AbstractMood disorders have been discussed as being in relation to glial pathology. S100B is a calcium-binding protein, and a marker of glial dysfunctions. Although alterations in the S100B expression may play a role in various central nervous system diseases, there are no studies on the potential role of S100B in mood disorders in adolescents and young adults . In a prospective two-year follow-up study, peripheral levels of S100B were investigated in 79 adolescent/young adult patients (aged 14–24 years), diagnosed with mood disorders and compared with 31 healthy control subjects. A comprehensive clinical interview was conducted which focused on clinical symptoms and diagnosis change. The diagnosis was established and verified at each control visit. Serum S100B concentrations were determined. We detected: lower S100B levels in medicated patients, compared with those who were drug-free, and healthy controls; higher S100B levels in a depressed group with a family history of affective disorder; correlations between age and medication status; sex-dependent differences in S100B levels; and lack a of correlation between the severity of depressive or hypo/manic symptoms. The results of our study indicate that S100B might be a trait-dependent rather than a state-dependent marker. Due to the lack of such studies in the youth population, further research should be performed. A relatively small sample size, a lack of exact age-matched control group, a high drop-out rate.

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Suicide attempts preceding completed suicide

The British Journal of Psychiatry ◽

10.1192/bjp.173.6.531 ◽

1998 ◽

Vol 173 (6) ◽

pp. 531-535 ◽

Cited By ~ 167

Author(s):

Erkki T. Isometsä ◽

Jouko K. Lönnqvist

Keyword(s):

Suicide Attempt ◽

Suicide Prevention ◽

Suicide Risk ◽

Suicide Attempts ◽

Early Recognition ◽

Preventive Measure ◽

Time Interval ◽

Psychological Autopsy ◽

Autopsy Study ◽

History Of

BackgroundThis study investigated three questions with major implications for suicide prevention: the sensitivity of the history of previous suicide attempt(s) as an indicator of suicide risk, the time interval from a preceding suicide attempt to the fatal one, and switching of suicide methods by those eventually completing suicide.MethodThe lifetime history of suicide attempts and the methods the victims (n=1397) used were examined in a nationwide psychological autopsy study comprising all suicides in Finland within a 12-month research period in 1987–1988.ResultsOverall, 56% of suicide victims were found to have died at their first suicide attempt, more males (62%) than females (38%). In 19% of males and 39% of females the victim had made a non-fatal attempt during the final year. Of the victims with previous attempts, 82% had used at least two different methods in their suicide attempts (the fatal included).ConclusionsMost male and a substantial proportion of female suicides die in their first suicide attempt, a fact that necessitates early recognition of suicide risk, particularly among males. Recognition of periods of high suicide risk on the grounds of recent non-fatal suicide attempts is likely to be important for suicide prevention among females. Subjects completing suicide commonly switch from one suicide method to another, a finding that weakens but does not negate the credibility of restrictions on the availability of lethal methods as a preventive measure.

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Why do polyunsaturated fatty acids lower serum cholesterol?

American Journal of Clinical Nutrition ◽

10.1093/ajcn/44.1.155 ◽

1986 ◽

Vol 44 (1) ◽

pp. 155-156 ◽

Cited By ~ 1

Author(s):

P Budowski

Keyword(s):

Fatty Acids ◽

Polyunsaturated Fatty Acids ◽

Serum Cholesterol ◽

Lower Serum ◽

Lower Serum Cholesterol

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Bakery products lower serum cholesterol concentrations in hypercholesterolemic men

American Journal of Clinical Nutrition ◽

10.1093/ajcn/54.5.836 ◽

1991 ◽

Vol 54 (5) ◽

pp. 836-840 ◽

Cited By ~ 13

Author(s):

J W Anderson ◽

S Riddell-Lawrence ◽

T L Floor ◽

D W Dillon ◽

P R Oeltgen

Keyword(s):

Serum Cholesterol ◽

Bakery Products ◽

Lower Serum ◽

Lower Serum Cholesterol

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Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

BMC Psychiatry ◽

10.1186/s12888-020-02891-8 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Jing-Xu Chen ◽

Jun-Hui Feng ◽

Li-Gang Zhang ◽

Yan Liu ◽

Fu-De Yang ◽

...

Keyword(s):

Major Depressive Disorder ◽

Uric Acid ◽

Depressive Disorder ◽

Suicide Risk ◽

Serum Levels ◽

Binary Logistic Regression Analysis ◽

Healthy Controls ◽

Major Depressive ◽

Cross Sectional ◽

Female Patients

Abstract Background Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients. Methods One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I.). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured. Results Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients. Conclusion Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.

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