Association Between Patent Foramen Ovale and Overt Ischemic Stroke in Children With Sickle Cell Disease

Ischemic stroke is one of the most devastating complications of sickle cell anemia (SCA). Previous studies have shown that intracardiac shunting including patent foramen ovale (PFO) can be a potential risk factor for stroke in children with SCA. This study investigates the association between PFO and overt ischemic stroke in the DISPLACE (Dissemination and Implementation of Stroke Prevention Looking at the Care Environment) study cohort of 5,247 children with SCA of whom 1,414 had at least one clinical non-contrast transthoracic echocardiogram. Presence of PFO was taken from the clinical report. Further, we assessed the association between PFO and other clinical and hemolytic factors in children with SCA such as history of abnormal sickle stroke screen [elevated Transcranial Doppler ultrasound (TCD) velocity] and patient's baseline hemoglobin. In 642 children for whom all data were available, the adjusted odds ratio (OR) for overt stroke was higher in those with PFO but this was not statistically significant (OR: 1.49, 95% CI: 0.20–11.03, p = 0.6994). With an OR of 0.85, the study suggested less PFOs in those with abnormal TCD, but this was not statistically significant (95% CI: 0.17–4.25, p = 0.8463). Overall, the prevalence of PFO in this large sub study of non-contrast echocardiography amongst children with SCA is much lower than previous smaller studies using bubble contrast echocardiography. Overt stroke was non-statistically more common in children with SCA and PFO, but there was no evidence that PFO was more common in those with abnormal TCD, the most important pediatric sickle stroke screen.

Traces of Early State formations in South East Georgia, Caucasus - response and impact on changes in the climate and environment Shiraqi Plane, South East Georgia, Caucasus

Study of past changes in environment and, its effect on human society delivers key information to reconstruct the hystorical past but also to project future changes and their effects. Study focus on South-East Georgia, Caucasus region, which represents natural polygon of long term changes in the environment. Study area represents semi-arid Shiraqi plain in South-East Georgia (see the map below). It is characterized with annual precipitation <600mm and shows open dry steppic landscape today. However, recent data collected using remote sensing and archaeological studies, deliver evidences of early human inhabitation of this area, starting from the Paleolithic and forming a constant chain of active settlement through the time, until sudden abrupt at the end of the Bronze Age. Geomorphologically Shiraqi plane represents 800 sqr. km of almost flat area with average height of 600 m above Sea level, surrounded by chains of mountains creating a natural walls surrounding the plane. There are almost no settlements in the area, devoid of water resources today. Archaeo-Botanic and soil studies assume that the region was covered by forests, Hydro modelling shows possibility of existence of well developed water network with a shallow lake in the center of plane. Remote sensing data and resent archaeological excavations at Didnauri site provides clear evidences of early state formation, with favorable paleo-environmental conditions. The goal of current study is to shed light on historic changes in the environment of the region, its natural and anthropogenic factors and consequently response of human society on these changes.

Nanotechnology and Environment Study

Nanotechnology has begun to be used to solve or at least mitigate environmental pollution problems, and in turn has provided a great opportunity to develop some strategies to protect the environment from pollution. Nanotechnology enables having the possibility to increase the efficiency of energy consumption, produce clean energy sources, solve the problem of water and air pollution and other environmental problems by developing new ways to provide and treat drinking water and discover air pollution. This stimulated the United Nations to pay attention to it and to monitor a plan to benefit from its applications in various fields. This paper reviews the impacts of nanotechnology on such environmental issues.

Prevalence and phenotypic impact of rare potentially damaging variants in autism spectrum disorder

Background The Autism Sequencing Consortium identified 102 high-confidence autism spectrum disorder (ASD) genes, showing that individuals with ASD and with potentially damaging single nucleotide variation (pdSNV) in these genes had lower cognitive levels and delayed age at walking, when compared to ASD participants without pdSNV. Here, we made use of a Swedish sample of individuals with ASD (called PAGES, for Population-Based Autism Genetics & Environment Study) to evaluate the frequency of pdSNV and their impact on medical and psychiatric phenotypes, using an epidemiological frame and universal health reporting. We then combine findings with those for potentially damaging copy number variation (pdCNV). Methods SNV and CNV calls were generated from whole-exome sequencing and chromosome microarray data, respectively. Birth and medical register data were used to collect phenotypes. Results Of 808 individuals assessed by sequencing, 69 (9%) had pdSNV in the 102 ASC genes, and 144 (18%) had pdSNV in the 102 ASC genes or in a larger set of curated neurodevelopmental genes (from the Deciphering Developmental Disorders study, the gene2phenotype database, and the Radboud University gene lists). Three or more individuals had pdSNV in GRIN2B, POGZ, SATB1, DYNC1H1, SCN8A, or CREBBP. In comparison, out of the 996 individuals from whom CNV were called, 105 (11%) carried one or more pdCNV, including four or more individuals with CNV in the recurrent 15q11q13, 22q11.2, and 16p11.2 loci. Carriers of pdSNV were more likely to have intellectual disability (ID) and epilepsy, while carriers of pdCNV showed increased rates of congenital anomalies and scholastic skill disorders. Carriers of either pdSNV or pdCNV were more likely to have ID, scholastic skill disorders, and epilepsy. Limitations The cohort only included individuals with autistic disorder, the more severe form of ASD, and phenotypes are defined from medical registers. Not all genes studied are definitively ASD genes, and we did not have de novo information to aid in classification. Conclusions In this epidemiological sample, rare pdSNV were more common than pdCNV and the combined yield of potentially damaging variation was substantial at 27%. The results provide compelling rationale for the use of high-throughout sequencing as part of routine clinical workup for ASD and support the development of precision medicine in ASD.

Edaphic components of Mangrove Dominated Lothian And Prentice Island In Sundarbans North -East Coast of India.

Physico-chcmical analysis of mangrove soils in two islands (Prentice and Lothian) in sundarban areas were carried out and compared to highlight the quality of the soils that facilitate the existence as well as survival various flora and fauna to play immense role in the stability of the environment. Study revealed that there were slight differences in the grain size, pH, organic carbon and exchangeable calcium (Ca12) and magnesium (Mg12) content in soils of these two islands. The litter of the mangrove forest might. play vital role not only on the variation of carbon to nitrogen ratio (C/N) and carbon to phosphorous ratio (C/P) but also retention ability of these essential nutritional elements in soils. Ca+2 and Mg+2 were the principal cations as observed in exchange reactions. Potassiun ion (K+) recorded comparatively higher values than the sodium ion (Na+) in these soils probably due to more amnily for K+ uptake in the existing biotic community as well as trapping capacity by edaphic components in these areas.

ІNFORMATION SUPPORT FOR TOURISM AND HOTEL BUSINESS DEVELOPMENT

The article substantiates the need to enhance the information support for tourism and hotel business which is currently associated with a range of information and methodological issues, such as the assessment of tourist flows; tourism and hotel market satisfaction, congruence between customer needs and supply in the tourist services market; assessing load infrastructure as well as anthropogenic effects on the environment; study on the state of industry development and measuring of its contribution into the total gross domestic product. The paper presents a research methodology to explore tourism and hotel business settings, in particular the regional tourist services market, based on the market environment evaluation, identification of factors affecting tourism actors’ performance efficiency and estimation of their impact on final economic outcomes. The above methodology involves a comprehensive approach to the application of theoretical and applied principles of sectoral and territorial analysis and aims at building the regional tourism policy key drivers. It is argued that in the context of new risks and challenges, modern Ukraine should pursue a robust constructive recreational and tourism policy. Depending on the level at which the policy is defined and implemented, this study makes out government policy, regional policy, and the policy of individual tourism and hotel businesses. As an effective solution, the findings suggest modeling a government recreational policy based on strategic planning which translates into a comprehensive document that includes analytical information and business forecasting, as well as an action plan including a set of activities and projects to be implemented by market participants in the tourism and hotel sector.

Comparing adolescent self staging of pubertal development with hormone biomarkers

Objectives Physical examinations to characterize pubertal maturation may be unacceptable for children enrolled in research studies. Studies confirm the utility of pubertal self staging for research, but there has been limited comparison of self examination with hormone biomarkers. Our objective was to assess concordance of pubertal self staging with hormone biomarkers of puberty. Methods Participants were enrolled in the Health Outcomes and Measures of the Environment Study, a longitudinal pregnancy and birth cohort study. At age 12 years, 139 females and 112 males completed pubertal self staging including breast and pubic hair development in females and pubic hair development in males. No clinical physical examination was performed. Hormone concentrations were measured in 102 females and 96 males including serum dehydroepiandrosterone sulfate, luteinizing hormone, and follicle-stimulating hormone in all; estradiol in females; and testosterone in males. Results Estradiol was significantly associated with female breast stage, even when adjusted for BMI, with geometric least squares means (95%CI) of 13.2 (8.7, 20.2), 38.3 (29.9, 49.1), 59.4 (39.8, 88.6), and 81.2 (45.6, 144) pg/mL for breast stage 1–2, 3, 4, and 5, respectively. Testosterone was significantly associated with male pubic hair stage, with adjusted geometric least squares means (95%CI) of 37.6 (19.9, 71.1), 43.4 (27.7, 68.3), 126 (78.4, 203), 275 (146, 521), and 559 (237, 1319) ng/dL for pubic hair stage 1, 2, 3, 4, and 5, respectively. Conclusions Self assessed pubertal development was positively associated with hormonal biomarkers of puberty.

Measuring the Effect of Neighborhood Racial Segregation on Fetal Growth

Prior studies of neighborhood racial segregation and intrauterine growth have not accounted for confounding factors in early life. We used the Life-Course Influences on Fetal Environment Study of births to Black women in metropolitan Detroit, 2009–2011, ( N = 1,408) to examine whether health and social conditions in childhood and adulthood confound or modify the association of neighborhood segregation (addresses during pregnancy geocoded to census tract racial composition) and gestational age-adjusted birthweight. Before adjusting for covariates, women living in a predominantly (≥75%) Black neighborhood gave birth to 47.3 grams (95% CI: –99.0, 4.4) lighter infants, on average, compared with women living in <75% Black neighborhoods. This association was confounded by adulthood (age at delivery, parity, neighborhood deprivation) and childhood (parental education, neighborhood racial composition) factors and modified by adulthood socioeconomic position. These findings underscore the complex relationship between neighborhood racial segregation and birth outcomes, which would be enhanced through a life course framework.