Cytologic follow up of Low-grade Squamous Intraepithelial Lesions in Pap smears after integrated treatment with antimicrobials followed by oral turmeric oil extract

CONTEXT AND OBJECTIVE: The concept that the presence of atypical squamous cells cannot exclude high-grade squamous intraepithelial lesions (ASC-H) was introduced in the 2001 Bethesda System of cervical cytology classification. This nomenclature defines cervical cancer precursor lesions. The objective of this study was to investigate the colpocytological-histological results from a three-year follow-up conducted on a cohort of women with reports of ASC-H who were attended during 2005-2006 at clinics of the Southern Metropolitan Healthcare Service of Santiago, Chile. DESIGN AND SETTING: Prospective cohort study at primary healthcare clinics in Santiago, Chile. METHODS : Colpocytological-histological follow-up was conducted over a three-year period on 92 women with cytological reports of ASC-H who were attended at primary healthcare clinics during 2005-2006. RESULTS : At the end of the follow-up period, high-grade lesions were evaluated and the following outcomes were observed: seven women presented invasive cancer (7.6%), 49 presented high-grade lesions (53.3%), 26 presented low-grade lesions (28.2%) and 10 presented normal results (10.9%). The "Conditional Probabilities Tree Diagram" was used to show the results from tests and the times of lesion detection. It demonstrated that, after a first report of ASC-H, clinical management needed to be interventionist. CONCLUSION: The follow-up on our cohort of women showed that the majority of uncertain ASC-H diagnoses (82.6%) had abnormal colposcopic results and that during the follow-up using ASC-H smears, two out of every three women developed high-grade lesions.

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Anal Squamous Intraepithelial Lesions (SILs) in Human Immunodeficiency Virus–Positive Men Who Have Sex With Men: Incidence and Risk Factors of SIL and of Progression and Clearance of Low-Grade SILs

The Journal of Infectious Diseases ◽

10.1093/infdis/jiz614 ◽

2019 ◽

Vol 222 (1) ◽

pp. 62-73 ◽

Cited By ~ 2

Author(s):

V W Jongen ◽

O Richel ◽

E Marra ◽

M L Siegenbeek van Heukelom ◽

A van Eeden ◽

...

Keyword(s):

Risk Factors ◽

Human Immunodeficiency Virus ◽

Hiv Positive ◽

Low Grade ◽

Squamous Intraepithelial Lesions ◽

Immunodeficiency Virus ◽

Anal Squamous Intraepithelial Lesions ◽

Sex With Men ◽

Intraepithelial Lesions

Abstract Background Human immunodeficiency virus (HIV)–positive men who have sex with men (MSM) are at risk of anal squamous cell carcinoma. Data are limited on the natural history of the precursor to this carcinoma, anal squamous intraepithelial lesions (SILs). Methods HIV-positive MSM were screened for histopathological SILs by means of high-resolution anoscopy (HRA). For participants without SILs at baseline, we estimated the cumulative incidence and risk factors for SILs. For those with low-grade SILs (LSILs) at baseline, the risk of progression to high-grade SILs (HSILs) and the clearance rate were estimated at the lesion level. Results Of 807 men without SILs at baseline, 107 underwent follow-up HRA between 1 to 4.5 years later. At the second visit 18 men (16.8%) showed LSIL, and 25 (23.4%) HSIL. Age was associated with incident LSILs (adjusted odds ratio [aOR], 2.10 per 10-year increase in age; P = .01). Of 393 men with LSILs at baseline, 114 underwent follow-up HRA 0.5 to 2.5 years later. Of the 177 LSILs found at baseline, 87 (49.2%) had cleared at the second visit, and 29 (16.4%) had progressed to HSILs. Conclusion Incident LSILs and HSILs were common during follow-up among HIV-positive MSM without dysplasia at baseline. Among men with LSILs at baseline, nearly half of these lesions cleared, and a small portion progressed.

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Low-Grade Squamous Intraepithelial Lesions of the Cervix With Marked Cytological Atypia-Clinical Follow-Up and Human Papillomavirus Genotyping

International Journal of Gynecological Pathology ◽

10.1097/pgp.0b013e31802f64ab ◽

2007 ◽

Vol 26 (4) ◽

pp. 457-462 ◽

Cited By ~ 11

Author(s):

Kay Park ◽

Lora H. Ellenson ◽

Edyta C. Pirog

Keyword(s):

Human Papillomavirus ◽

Low Grade ◽

Squamous Intraepithelial Lesions ◽

Cytological Atypia ◽

Intraepithelial Lesions

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Performance of a Fluid-Based, Thin-Layer Papanicolaou Smear Method in the Clinical Setting of an Independent Laboratory and an Outpatient Screening Population in New England

Archives of Pathology & Laboratory Medicine ◽

10.5858/1999-123-0817-poafbt ◽

1999 ◽

Vol 123 (9) ◽

pp. 817-821 ◽

Cited By ~ 5

Author(s):

Luis A. Díaz-Rosario ◽

Salim E. Kabawat

Keyword(s):

Thin Layer ◽

New England ◽

Pap Test ◽

Pap Smears ◽

Low Grade ◽

Squamous Intraepithelial Lesions ◽

Screening Population ◽

Thin Layer Method ◽

Intraepithelial Lesion ◽

Intraepithelial Lesions

Abstract Background.—A patented, fluid-based, thin-layer method for preparation of Papanicolaou (Pap) smears (ThinPrep Pap test) has been reported to be significantly more effective than the conventional smear invented by George Papanicolaou. We tested this position by comparing the cytologic diagnosis and specimen adequacy results obtained using the ThinPrep method with data from conventional Pap smears obtained from a similar population. Methods.—Test results of 56 339 ThinPrep specimens were compared with results from 74 756 conventional smear cases obtained from the same sources in a corresponding period of the previous year. Results.—The use of ThinPrep for cervicovaginal cytology produced a 75.14% increase in the detection of low-grade squamous intraepithelial lesions and higher diagnoses. Detection of low-grade squamous intraepithelial lesions increased by 71.65% (from 1.58% to 2.71%), and detection of high-grade squamous intraepithelial lesions increased by 102.54% (from 0.26% to 0.52%). There was a 39.11% decrease in the atypical squamous cells of undetermined significance–intraepithelial lesion ratio (from 2.07 to 1.26). There were also marked decreases in the number of specimens categorized as “satisfactory but limited,” owing to obscuring inflammation (−94.34%), obscuring blood (−99.84%), and poor fixation (−99.25%). Conclusion.—ThinPrep produced increased detection of premalignant precursors while improving specimen adequacy.

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Assessment of cytologic follow-up as the recommended management for patients with atypical squamous cells of undetermined significance or low grade squamous intraepithelial lesions

Cancer ◽

10.1002/(sici)1097-0142(19980225)84:1<5::aid-cncr2>3.0.co;2-q ◽

1998 ◽

Vol 84 (1) ◽

pp. 5-10 ◽

Cited By ~ 27

Author(s):

Ken W. Alanen ◽

Laurie M. Elit ◽

Patricia A. Molinaro ◽

Catherine M. McLachlin

Keyword(s):

Low Grade ◽

Squamous Intraepithelial Lesions ◽

Squamous Cells ◽

Intraepithelial Lesions ◽

Undetermined Significance

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Histopathologic and Cytologic Follow-Up in High Risk Male Patients with Unsatisfactory Anal Cytology

Pathology Research International ◽

10.1155/2017/9780213 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Daniel J. Zaccarini ◽

Kamal K. Khurana

Keyword(s):

High Risk ◽

Epithelial Cell ◽

Pap Smear ◽

Significant Risk ◽

Pap Smears ◽

Low Grade ◽

Anal Cytology ◽

Male Patients ◽

Intraepithelial Lesions

Objective. Anal cytology is being increasingly used as part of anal cancer screening in patients at high risk for anal neoplasia. Most studies in anal cytology have focused on correlating the abnormal anal Pap smear with histopathologic outcomes. The aim of this study was to document histopathologic or repeat anal cytology outcomes in patients with unsatisfactory cytology. Materials and Methods. Unsatisfactory anal Pap tests in high risk male patients were correlated with follow-up histopathologic diagnoses or cytology. Results. 1205 anal tests were performed during the study period and 214 (17.8%) were unsatisfactory. Adequate follow-up cytology was available in 75 cases and revealed epithelial cell abnormality (ECA) in 40% [30/75] (atypical squamous cells of undetermined significance (ASCUS) [20%] and low-grade squamous intraepithelial lesions (LGSIL) [20%]) and was negative for intraepithelial lesion or malignancy (NILM) in 60% [45/75] of cases. 28.7% of unsatisfactory Pap smears had unsatisfactory repeat cytology. Histopathological follow-up on these unsatisfactory Pap smears revealed anal intraepithelial neoplasia (AIN) 1 and AIN 2/3 or 2/3+ in 39% and 18% of the total number of biopsy cases, respectively. Conclusions. High risk male patients with unsatisfactory Pap smears are at significant risk of epithelial cell abnormality and histopathologically verifiable anal intraepithelial lesions.

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Colposcopic characteristics and Lugol׳s staining differentiate anal high-grade and low-grade squamous intraepithelial lesions during high resolution anoscopy

Papillomavirus Research ◽

10.1016/j.pvr.2015.06.004 ◽

2015 ◽

Vol 1 ◽

pp. 101-108 ◽

Cited By ~ 17

Author(s):

Naomi Jay ◽

J. Michael Berry ◽

Christine Miaskowski ◽

Misha Cohen ◽

Elizabeth Holly ◽

...

Keyword(s):

High Resolution ◽

Low Grade ◽

High Grade ◽

Squamous Intraepithelial Lesions ◽

Intraepithelial Lesions

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Colposcopy, cervical cytology and human papillomavirus detection as screening tools for cervical cancer

Eastern Mediterranean Health Journal ◽

10.26719/2001.7.1-2.100 ◽

2001 ◽

Vol 7 (1-2) ◽

pp. 100-105

Author(s):

Al Alwan Al Alwan

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Pap Test ◽

Screening Tools ◽

Low Grade ◽

Squamous Intraepithelial Lesions ◽

Sampling Device ◽

Squamous Cells ◽

The Bethesda System ◽

Intraepithelial Lesions

A cohort of 77 women referred for routine screening or investigation of Pap test abnormality underwent colposcopic examination. Pap-stained liquid-based preparations were diagnosed and categorized according to the Bethesda system. Residual material on the sampling device was used to detect high-risk oncogenic human papillomavirus DNA. Although the colposcopic failure rate was higher than that of cytology, no lesion was missed when both methods were used together. High-risk types were recorded in 24% of patients with atypical squamous cells of undetermined significance, 45% with low-grade squamous intraepithelial lesions and 79% with high-grade squamous intraepithelial lesions-indicating that the efficacy of cytological screening can be improved by papillomavirus detection.

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