In Vitro antibacterial activity of Ta2O5 doped glass-ceramics against pathogenic bacteria

2018 ◽  
Vol 764 ◽  
pp. 10-16 ◽  
Author(s):  
Madeeha Riaz ◽  
Rehana Zia ◽  
Farhat Saleemi ◽  
Tousif Hussain
Keyword(s):  
Antibacterial Activity ◽  
Pathogenic Bacteria ◽  
Glass Ceramics ◽  
In Vitro Antibacterial Activity ◽  
Doped Glass

scholarly journals In vivo and in vitro antibacterial activity of neomycin against plant pathogenic bacteria

2011 ◽  
Vol 6 (34) ◽  
pp. 6829-6834, ◽  
Author(s):  
Tao Ke ◽  
Fan Jieyu ◽  
Shi Guanying ◽  
Zhang Xingang ◽  
Zhao Haoyu ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Pathogenic Bacteria ◽  
Plant Pathogenic Bacteria ◽  
In Vitro Antibacterial Activity

scholarly journals Synthesis and In Vitro Antibacterial Activity of Quaternized 10-Methoxycanthin-6-one Derivatives

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1553 ◽  
Author(s):  
Na Li ◽  
Dan Liu ◽  
Jiang-Kun Dai ◽  
Jin-Yi Wang ◽  
Jun-Ru Wang
Keyword(s):  
Antibacterial Activity ◽  
Seed Germination ◽  
Pathogenic Bacteria ◽  
Dilution Method ◽  
Highly Active ◽  
Structure Activity ◽  
In Vitro Antibacterial Activity ◽  
Potential Activity ◽  
Low Cytotoxicity

Background: Based on our previous work, we found that 10-methoxycanthin-6-one displayed potential antibacterial activity and quaternization was an available method for increasing the antibacterial activity. Here, we explored the antibacterial activity of quaternized 10-methoxy canthin-6-one derivatives. Methods and Results: Twenty-two new 3-N-benzylated 10-methoxy canthin-6-ones were designed and synthesized through quaternization reaction. The in vitro antibacterial activity against three bacteria was evaluated by the double dilution method. Moreover, the structure–activity relationships (SARs) were carefully summarized in order to guide the development of antibacterial canthin-6-one agents. Two highly active compounds (6p and 6t) displayed 8-fold superiority (MIC = 3.91 µg/mL) against agricultural pathogenic bacteria R. solanacearum and P. syringae compared to agrochemical streptomycin sulfate, and showed potential activity against B. cereus. Moreover, these two compounds exhibited good “drug-like” properties, low cytotoxicity, and no inhibition on seed germination. Conclusions: This work provides two new effective quaternized canthin-6-one derivatives as candidate bactericide, promoting the development of natural-sourced bactericides and preservatives.

scholarly journals Synthesis and in vitro Antibacterial Activity of Quaternization 10-Methoxycanthin-6-one Derivatives

2019 ◽  
Author(s):  
Na Li ◽  
Jiang-Kun Dai ◽  
Dan Liu ◽  
Jin-Yi Wang ◽  
Jun-Ru Wang
Keyword(s):  
Antibacterial Activity ◽  
Natural Products ◽  
Minimum Inhibitory Concentration ◽  
Pathogenic Bacteria ◽  
Antibacterial Agents ◽  
Inhibitory Concentration ◽  
Dilution Method ◽  
In Vitro Antibacterial Activity

Natural products are an important source of antibacterial agents. Canthin-6-one alkaloids have displayed potential antibacterial activity based on our previous work. In order to improve the activity, twenty-two new 3-N-benzylated 10-methoxy canthin-6-ones were designed and synthesized through quaternization reaction. The in vitro antibacterial activity against three bacteria was evaluated by double dilution method. Four compounds (6f, 6i, 6p and 6t) displayed 2-fold superiority (minimum inhibitory concentration (MIC) = 3.91 µg/mL) against agricultural pathogenic bacteria R. solanacearum and P. syringae than agrochemical propineb. Moreover, the structure–activity relationships (SARs) were also carefully summarized in order to guide the development of antibacterial canthin-6-one agents.

scholarly journals Maclura tinctoria Extracts: In Vitro Antibacterial Activity against Aeromonas hydrophila and Sedative Effect in Rhamdia quelen

Fishes ◽  
2021 ◽  
Vol 6 (3) ◽  
pp. 25
Author(s):  
Luana da Costa Pires ◽  
Patricia Rodrigues ◽  
Quelen Iane Garlet ◽  
Luisa Barichello Barbosa ◽  
Bibiana Petri da Silveira ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Phenolic Compounds ◽  
Pathogenic Bacteria ◽  
Sedative Effect ◽  
In Vitro Antimicrobial Activity ◽  
Normal Behavior ◽  
In Vitro Antibacterial Activity ◽  
Light Sedation

Maclura tinctoria is a tree species native from Brazil and rich in phenolic compounds. Since plant antibacterial activity is highly associated with phenolic compound concentration, we aim to evaluate the in vitro antimicrobial activity of different extracts against fish pathogenic bacteria. In addition, some phenolic compounds have central depressant effects and can be useful in aquaculture due to possible sedative and/or anesthetic effects. Four M. tinctoria extracts were extracted separately with ethanol; leaves (LE), bark (BE), heartwood (HE), and the sapwood (SE). In vitro antimicrobial activity was tested against Aeromonas strains at concentrations of 6400 to 3.125 μg/mL. The sedative effect was evaluated for 24 h with 30 and 100 mg/L concentrations. Chemical composition was analyzed by HPLC-DAD-MS. The HE extract had the best MIC (400 µg/mL) and MBC (800 µg/mL) compared to the LE, BE, and SE extracts. LE extract induced deep sedation and the BE, SE, and HE extracts induced light sedation. Additionally, BE, SE, and HE induced a normal behavior without side effects. Polyphenolic compounds with antimicrobial activity and sedative effects were identified mainly in HE. Thus, HE extract is safe and can be used as a sedative for silver catfish.

Synthesis and evaluation of factors affecting the in vitro bioactivity and antibacterial activity of bioactive glass ceramics

2017 ◽  
Vol 31 (01) ◽  
pp. 1650246
Author(s):  
Madeeha Riaz ◽  
Rehana Zia ◽  
Farhat Saleemi
Keyword(s):  
Antibacterial Activity ◽  
Dissolution Rate ◽  
Pathogenic Bacteria ◽  
Antibacterial Properties ◽  
Glass Ceramics ◽  
Static Condition ◽  
In Vitro Bioactivity ◽  
Factors Affecting ◽  
High Dissolution Rate

In the present study, two novel silicate glass-ceramics having chemical composition 38SiO2–41CaO–6P2O5–([Formula: see text])Na2O–[Formula: see text]CaF2 ([Formula: see text], 0.43 mol%) were synthesized. These glass derivatives were subjected to stimulated body fluid for 24 days in SBF under static condition at [Formula: see text]C in order to evaluate the bioactive properties of specimens. The antibacterial activity of glass ceramics against three pathogenic bacteria was determined using the modified Kirby Bauer method. It was found that the antibacterial activity primarily depends on the dissolution rate; faster release of ions caused rapid increase in the pH of the solution. Antibacterial properties were found to be strongly affected by changes in the pH of supernatant. The in vitro bioactivity assays showed that both glass derivatives were capable of bonding with bone and secondly effectively inhibit bacteria. However, the glass ceramic without CaF2 (B2) showed high dissolution rate, better bioactive ability and stronger antibacterial efficacy.

Sign in / Sign up

Export Citation Format

Share Document