P4-220: A comparison of family caregiver burden in relation to dementia severity in Alzheimer's disease and vascular dementia

2006 ◽  
Vol 2 ◽  
pp. S581-S581
Author(s):  
Bong-Goo Yoo ◽  
Tae-You Kim ◽  
Sang-Min Sung ◽  
Eung-Gyu Kim ◽  
Sang-Chan Lee ◽  
...  
2015 ◽  
Vol 27 (8) ◽  
pp. 1355-1364 ◽  
Author(s):  
Myonghwa Park ◽  
Mira Sung ◽  
Sun Kyung Kim ◽  
Sungjin Kim ◽  
Dong Young Lee

ABSTRACTBackground:Caregiver burden is a complex and multidimensional construct. Although previous studies have explored numerous factors associated with caregiver burden, these factors have not been identified with a large population-based sample in a theory-based multidimensional way. This study explores multidimensional determinants associated with family caregiver burden to determine the main contributors of caregiver burden in Alzheimer's disease (AD) using a large community dataset.Methods:A retrospective secondary data analysis was conducted on 1,133 patients with AD and 1,133 primary caregivers who were registered in a metropolitan city dementia center in South Korea. The patient data included socio-demographic and disease profiles. The caregiver data consisted of socio-demographic and caregiving profiles.Results:The study results identified that dementia-related factors were the most significant factors, representing 25.6% of caregiver burden and were followed by caregiving-related factors explaining caregiver burden significantly. Behavioral problems and instrumental activities of daily living (IADL) dependency of the patient, spousal relationship, hours of caregiving, and the number of diseases associated with the caregiver were found to be significant individual variables.Conclusions:It is vital to develop a service and support program with a greater emphasis on the behavioral problems and IADL deficiency of patients with AD as well as on improving the competence ability of caregivers to deal with such difficulties.


2014 ◽  
Vol 30 (9) ◽  
pp. 891-899 ◽  
Author(s):  
Grazia D'Onofrio ◽  
Daniele Sancarlo ◽  
Filomena Addante ◽  
Filomena Ciccone ◽  
Leandro Cascavilla ◽  
...  

Author(s):  
Burbaeva G.Sh. ◽  
Androsova L.V. ◽  
Vorobyeva E.A. ◽  
Savushkina O.K.

The aim of the study was to evaluate the rate of polymerization of tubulin into microtubules and determine the level of colchicine binding (colchicine-binding activity of tubulin) in the prefrontal cortex in schizophrenia, vascular dementia (VD) and control. Colchicine-binding activity of tubulin was determined by Sherlinе in tubulin-enriched extracts of proteins from the samples. Measurement of light scattering during the polymerization of the tubulin was carried out using the nephelometric method at a wavelength of 450-550 nm. There was a significant decrease in colchicine-binding activity and the rate of tubulin polymerization in the prefrontal cortex in both diseases, and in VD to a greater extent than in schizophrenia. The obtained results suggest that not only in Alzheimer's disease, but also in other mental diseases such as schizophrenia and VD, there is a decrease in the level of tubulin in the prefrontal cortex of the brain, although to a lesser extent than in Alzheimer's disease, and consequently the amount of microtubules.


2016 ◽  
Vol 12 (3) ◽  
pp. 226-237 ◽  
Author(s):  
Ghulam M. Ashraf ◽  
Sandesh Chibber ◽  
. Mohammad ◽  
Syed K. Zaidi ◽  
Shams Tabrez ◽  
...  

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