scholarly journals P2-245: Dysregulation of brain insulin signaling: A mechanistic link between diabetes and Alzheimer's disease

2010 ◽  
Vol 6 ◽  
pp. S386-S386
Author(s):  
Cheng-Xin Gong ◽  
Ying Liu ◽  
Yanqiu Deng ◽  
Fei Liu ◽  
Inge Grundke-Iqbal ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Insulin Signaling ◽  
Brain Insulin

scholarly journals Regulation of brain insulin signaling: A new function for tau

2017 ◽  
Vol 214 (8) ◽  
pp. 2171-2173 ◽  
Author(s):  
Maud Gratuze ◽  
Emmanuel Planel
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tau Protein ◽  
Insulin Signaling ◽  
Loss Of Function ◽  
Brain Insulin ◽  
The Brain

In this issue of JEM, Marciniak et al. (https://doi.org/10.1084/jem.20161731) identify a putative novel function of tau protein as a regulator of insulin signaling in the brain. They find that tau deletion impairs hippocampal response to insulin through IRS-1 and PTEN dysregulation and suggest that, in Alzheimer’s disease, impairment of brain insulin signaling might occur via tau loss of function.

scholarly journals mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease

2016 ◽  
Vol 13 (2) ◽  
pp. 152-167 ◽  
Author(s):  
Andrés Norambuena ◽  
Horst Wallrabe ◽  
Lloyd McMahon ◽  
Antonia Silva ◽  
Eric Swanson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cell Cycle ◽  
Alzheimer's Disease ◽  
Insulin Signaling ◽  
Neuronal Cell ◽  
Cell Cycle Reentry ◽  
Brain Insulin

scholarly journals Deregulation of brain insulin signaling in Alzheimer’s disease

2014 ◽  
Vol 30 (2) ◽  
pp. 282-294 ◽  
Author(s):  
Yanxing Chen ◽  
Yanqiu Deng ◽  
Baorong Zhang ◽  
Cheng-Xin Gong
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Insulin Signaling ◽  
Brain Insulin

scholarly journals Brain Insulin Signaling and Alzheimer's Disease: Current Evidence and Future Directions

2011 ◽  
Vol 46 (1) ◽  
pp. 4-10 ◽  
Author(s):  
Helgi B. Schiöth ◽  
Suzanne Craft ◽  
Samantha J. Brooks ◽  
William H. Frey ◽  
Christian Benedict
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Insulin Signaling ◽  
Current Evidence ◽  
Future Directions ◽  
Brain Insulin

scholarly journals Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1236
Author(s):  
Jesús Burillo ◽  
Patricia Marqués ◽  
Beatriz Jiménez ◽  
Carlos González-Blanco ◽  
Manuel Benito ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Alzheimer's Disease ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Signaling ◽  
Molecular Mechanisms ◽  
Progressive Disease

Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of insulin resistance. The term insulin resistance is very wide and could affect different proteins involved in insulin signaling, as well as other mechanisms. In this review, we have analyzed the main molecular mechanisms that could be involved in the connection between type 2 diabetes and neurodegeneration, in general, and more specifically with the appearance of Alzheimer’s disease. We have studied, in more detail, the different processes involved, such as inflammation, endoplasmic reticulum stress, autophagy, and mitochondrial dysfunction.

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