P3-125: Association between antioxidant level in blood and dementia: A population-based cross-sectional case-control study

Abstract Background. The association between rheumatoid arthritis (RA) and periodontitis remains unclear. Methods. We studied oral health and periodontitis in a population-based case-control study of individuals with ≥ 10 remaining teeth ≥61 years of age and either with, or without a diagnosis of RA. 126 dentate individuals with RA were recruited together with age-matched control individuals without RA. The control individuals were recruited from the general population from the same city (n=249). A dental examination including a panoramic radiograph was performed on all participants. All individuals with RA were examined and medical records were reviewed by a rheumatologist. In the control group, none of the participants presented with symptoms of RA and their medical records were also negative. Results. The RA group included more women (66.7 % vs. 55.8 %) (p<0.01). Individuals in the RA group had a higher body mass index (BMI) (p<0.001). A diagnosis of periodontitis was more common in the RA group (61.1%) than in the control group (33.7 %) (p=0.001). Binary logistic regression analysis identified that a BMI > 25 (OR 6.2, 95% CI 3.6, 10.5, p= 0.000), periodontitis (OR 2.5 95% CI 1.5, 4.2 p=0.000), and female gender (OR 2.3, 95% CI 1.3-4.0, p=0.003) were associated with RA. Conclusion. RA was associated a diagnosis of periodontitis.

Download Full-text

Association of natural anti-platelet factor 4/heparin antibodies with periodontal disease

Blood ◽

10.1182/blood-2011-03-342857 ◽

2011 ◽

Vol 118 (5) ◽

pp. 1395-1401 ◽

Cited By ~ 63

Author(s):

Andreas Greinacher ◽

Birte Holtfreter ◽

Krystin Krauel ◽

Daniela Gätke ◽

Claudia Weber ◽

...

Keyword(s):

Immune Response ◽

Case Control Study ◽

Normal Population ◽

Population Based ◽

Case Control ◽

Platelet Factor 4 ◽

Periodontal Pathogens ◽

Cross Sectional ◽

Platelet Factor ◽

Control Study

Abstract Platelet factor 4 (PF4) and heparin (H) form PF4/H complexes, the target of the immune reaction in heparin-induced thrombocytopenia (HIT). HIT seems to be a secondary immune response as anti-PF4/H-IgG antibodies occur as early as day 4 of heparin treatment. This study investigated whether prevalent infections such as periodontitis may induce the PF4/H immune response as: (1) natural anti-PF4/H Abs are present in the normal population; (2) PF4 bound to bacteria exposes the same antigen(s) as PF4/H complexes; and (3) sepsis induces PF4/H Abs in mice. We found PF4 bound to periodontal pathogens (Aggregatibacter actinomycetemcomitans; Porphyromonas gingivalis) enabling subsequent binding of human anti-PF4/H Abs. The association of natural PF4/H Abs and periodontitis was assessed in a case-control study, enrolling individuals with natural anti-PF4/H Abs (n = 40 matched pairs), and in the cross-sectional population-based Study of Health in Pomerania (SHIP; n = 3500). Both studies showed a robust association between periodontitis and presence of anti-PF4/H Abs independent of inflammation markers (case-control study: lowest vs highest tertile, odds ratio, 7.12 [95% confidence interval, 1.73-46.13; P = .005]; SHIP study, ptrend ≤ 0.001). Thus, preimmunization to PF4/bacteria complexes by prevalent infections, for example, periodontitis, likely explains the presence of natural anti-PF4/heparin Abs and the early occurrence of anti-PF4/H-IgG in HIT.

Download Full-text

The status and correlates of depression and anxiety among breast-cancer survivors in Eastern China: a population-based, cross-sectional case–control study

BMC Public Health ◽

10.1186/1471-2458-14-326 ◽

2014 ◽

Vol 14 (1) ◽

Cited By ~ 23

Author(s):

Feng Wang ◽

Jiajia Liu ◽

Liyuan Liu ◽

Fei Wang ◽

Zhongbing Ma ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Survivors ◽

Case Control Study ◽

Eastern China ◽

Population Based ◽

Case Control ◽

Depression And Anxiety ◽

Cross Sectional ◽

The Status ◽

Control Study

Download Full-text

Lack of association between genetic variants in the 19q13.32 region and CHD risk in the Algerian population: a population-based nested case-control study

African Health Sciences ◽

10.4314/ahs.v20i2.25 ◽

2020 ◽

Vol 20 (2) ◽

pp. 735-744

Author(s):

Houssam Boulenouar ◽

Sarah Aicha Lardjam Hetraf ◽

Hadjira Ouhaibi Djellouli ◽

Djabaria Naima Meroufel ◽

Faouzia Zemani Fodil ◽

...

Keyword(s):

Genetic Variants ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Cross Sectional ◽

Chd Risk ◽

Algerian Population ◽

Cardiometabolic Disorders ◽

Nested Case Control ◽

Control Study

Background: Coronary Heart Disease (CHD) is a major cause of morbidity and mortality over the world; intermediate traits associated with CHD commonly studied can be influenced by a combination of genetic and environmental factors. Objective: We found previously significant association between three genetic polymorphisms, and the lipid profile variations in the Algerian population. Considering these findings, we therefore decided to assess the relationships between these polymorphisms and CHD risk. Methods: We performed a population-based, cross-sectional study, of 787 individuals recruited in the city of Oran, in which, a nested case-control study for MetS, T2D, HBP, obesity and CHD were performed. Subjects were genotyped for four SNP rs7412, rs429358 rs4420638 and rs439401 located in the 19q13.32 region. Results: The T allele of rs439401 confers a high risk of hypertension with an odds ratio (OR) of 1.46 (95% CI [1.12-1.9], p = 0.006) and the G allele of rs4420638 was significantly associated with a decreased risk of obesity, OR 0.48 (95% CI [0.29- 0.81], p = 0.004). No associations were found for MetS, T2D and CHD. Conclusion: Although the studied genetic variants were not associated with the risk of CHD, the 19q13.32 locus was associated with some of the cardiometabolic disorders in Algerian subjects. Keywords: Genetics; high blood pressure; CHD risk; obesity; Algerian population.

Download Full-text