Long-term (2004–2015) tendencies and variabilities of tropical UTLS water vapor mixing ratio and temperature observed by AURA/MLS using multivariate regression analysis

2016 ◽  
Vol 147 ◽  
pp. 156-165 ◽  
Author(s):  
S. Sridharan ◽  
M. Sandhya
Keyword(s):  
Regression Analysis ◽  
Water Vapor ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Mixing Ratio ◽  
Water Vapor Mixing Ratio

Hepatic steatosis as measured by the computed attenuation parameter predicts fibrosis in long-term methotrexate use

2021 ◽  
pp. e20200040
Author(s):  
Marcel Tomaszewski ◽  
Monica Dahiya ◽  
Seyed Amir Mohajerani ◽  
Hanaa Punja ◽  
Hin Hin Ko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Regression Analysis ◽  
Hepatic Steatosis ◽  
Multivariate Regression ◽  
Transient Elastography ◽  
Multivariate Regression Analysis ◽  
Attenuation Parameter ◽  
Dermatologic Disease ◽  
Severe Fibrosis

Introduction: To determine predictors of hepatic steatosis by the computed attenuation parameter (CAP) and fibrosis via transient elastography (TE) in persons on methotrexate (MTX) therapy with rheumatologic and dermatologic diseases. Methods: A single-centred retrospective cohort study was performed. Patients on >6 months of MTX for a rheumatologic or dermatologic disease who had undergone TE from January 2015 to September 2019 were included. Multivariate analysis was performed to determine predictors of steatosis and fibrosis. Results: A total of 172 patients on methotrexate were included. Psoriasis was the most frequent diagnosis ( n = 55), followed by rheumatoid arthritis ( n = 45) and psoriatic arthritis ( n = 34). Steatosis (CAP ≥245 dB/m) was present in 69.8% of patients. Multivariate regression analysis revealed that diabetes mellitus (OR 10.47, 95% CI 1.42–75.35), hypertension (OR 5.15, 95% CI 1.75–15.38), and BMI ≥30 kg/m2 (OR 16.47, 95% CI 5.56–45.56) were predictors of steatosis (CAP ≥245 dB/m). Predictors of moderate to severe fibrosis (Metavir ≥F2 = TE ≥8.0kPa) by multivariate regression analysis included moderate to severe steatosis (CAP ≥270 dB/m) (OR 8.36, 95% CI 1.88–37.14), diabetes mellitus (OR 2.85, 95% CI 1.09–7.48), hypertension (OR 5.4, 95% CI 2.23–13.00), dyslipidemia (OR 3.71, 95% CI 1.50–9.18), and moderate alcohol use (OR 3.06, 95% CI 1.2–7.49). Conclusions: In patients on MTX for rheumatologic and dermatologic diseases, hepatic steatosis as measured by CAP was common and moderate to severe steatosis predicted moderate to severe fibrosis.

scholarly journals A186 HEPATIC STEATOSIS PREDICTS FIBROSIS IN LONG-TERM METHOTREXATE USE

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. 57-58
Author(s):  
M Tomaszewski ◽  
M Dahiya ◽  
A Mohajerani ◽  
H Punja ◽  
H Ko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Regression Analysis ◽  
Hepatic Steatosis ◽  
Hepatic Fibrosis ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Alcoholic Fatty Liver ◽  
Significant Fibrosis ◽  
Non Invasive

Abstract Background Methotrexate (MTX) is effective for dermatologic and rheumatologic conditions such as psoriasis (Ps), psoriatic arthritis (PsO) and rheumatoid arthritis (RA). Long-term MTX use may be complicated by hepatic fibrosis, although patient, disease factors and the mechanism remain unclear. Transient elastography (TE) is a non-invasive measure of hepatic fibrosis that is often used as surveillance in this patient population. Patients with Ps and PsO have higher rates of non-alcoholic fatty liver disease. The controlled attenuation parameter (CAP) measurement is a non-invasive test that correlates with histologic degree of steatosis. To our knowledge, no studies have evaluated hepatic steatosis via CAP scores in MTX use. Aims To determine the prevalence of steatosis and significant fibrosis (F≥stage 2) in persons on MTX therapy and to determine the predictive factors for these events. Methods A single centred retrospective cohort study was performed. Patients on >6 months of MTX for a dermatologic or rheumatologic disease who had undergone TE from January 2015 to September 2019 were included. Demographic variables, laboratory investigations, TE and CAP scores were collected. Multivariate analysis was performed to determine predictors of steatosis and fibrosis. Results A total of 177 patients on methotrexate were included. Ps was the most frequent diagnosis (n=52) followed by RA (n=50) and PsO (n=38). Steatosis (CAP≥245 dB/m) was present in 73.9% of patients. Patients with steatosis had significantly more fibrosis and a higher BMI than those without steatosis (CAP<245 dB/m). Higher CAP score was correlated with increased lifetime dose of methotrexate by Pearson correlation analysis (r=0.48, p=0.001) (n=85 patients). Multivariate regression analysis revealed that diabetes mellitus (OR 10.5, 95% CI 1.38–80.60), hypertension (OR 4.97, 95% CI 1.66–14.84), and BMI> 30 (OR 10.1, 95% CI 1.88–37.14) were predictors of steatosis (CAP≥245 dB/m). Predictors of METAVIR≥F2 (TE≥8.0 kPa) by multivariate regression analysis included CAP score of ≥270 (OR 8.36, 95% CI 1.88–37.14), diabetes mellitus (OR 2.85, 95% CI 1.09–7.48), hypertension (OR 5.4, 95% CI 2.23–13.0), dyslipidemia (OR 3.71, 95% CI 1.50–9.18) and alcohol use (OR 3.06, 95% CI 1.2–7.49). Conclusions In patients on MTX for rheumatologic and dermatologic diseases, hepatic steatosis was common and predicted significant fibrosis. Additionally, increasing MTX exposure is correlated with steatosis. Features of the metabolic syndrome including diabetes, hypertension or obesity were predictors of both steatosis and fibrosis (F≥2). Further study is needed to evaluate if steatosis is a mechanism by which fibrosis occurs in patients on MTX, or if it due to other patient factors. Funding Agencies None

scholarly journals Long-term behavior of the concentration of the minor constituents in the mesosphere – a model study

2009 ◽  
Vol 9 (8) ◽  
pp. 2779-2792 ◽  
Author(s):  
M. Grygalashvyly ◽  
G. R. Sonnemann ◽  
P. Hartogh
Keyword(s):  
Water Vapor ◽  
Middle Atmosphere ◽  
Model Simulation ◽  
Vapor Concentration ◽  
Mixing Ratio ◽  
Constant Growth Rate ◽  
Model Calculations ◽  
Water Vapor Mixing Ratio ◽  
Long Term Behavior

Abstract. We investigate the influence the rising concentrations of methane, nitrous oxide and carbon dioxide which have occurred since the pre-industrial era, have had on the chemistry of the mesosphere. For this investigation we use our global 3-D-model COMMA-IAP which was designed for the exploration of the MLT-region and in particular the extended mesopause region. Assumptions and approximations for the trends in the Lyman-α flux (needed for the water vapor dissociation rate), methane and the water vapor mixing ratio at the hygropause are necessary to accomplish this study. To approximate the solar Lyman-α flux back to the pre-industrial time, we derived a quadratic fit using the sunspot number record which extends back to 1749 and is the only solar proxy available for the Lyman-α flux prior to 1947. We assume that methane increases with a constant growth rate from the pre-industrial era to the present. An unsolved problem for the model calculations consists of how the water vapor mixing ratio at the hygropause should be specified during this period. We assume that the hygropause was dryer during pre-industrial times than the present. As a consequence of methane oxidation, the model simulation indicates that the middle atmosphere has become more humid as a result of the rising methane concentration, but with some dependence on height and with a small time delay of few years. The solar influence on the water vapor mixing ratio is insignificant below about 80 km in summer high latitudes, but becomes increasingly more important above this altitude. The enhanced water vapor concentration increases the hydrogen radical concentration and reduces the mesospheric ozone. A second region of stronger ozone decrease is located in the vicinity of the stratopause. Increases in CO2 concentration enhance slightly the concentration of CO in the mesosphere. However, its influence upon the chemistry is small and its main effect is connected with a cooling of the upper atmosphere. The long-term behavior of water vapor is discussed in particular with respect to its impact on the NLC region.

scholarly journals Long-term effect of participation in one-month alcohol abstinence campaign on individual consumption

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
A Terebessy ◽  
V Pongor ◽  
Z s Horváth ◽  
J-H Ivers ◽  
M Pénzes ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Alcohol Consumption ◽  
Success Rate ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Reliable Change Index ◽  
Regression Analyses ◽  
One Year

Abstract Objective There is limited amount of evidence concerning the effect of population-based interventions. Dry November campaign asks people to go booze-free for a month. The goal of our study was to assess whether success rate of participation in the 2017 Dry November campaign leads to long-term change in alcohol consumption of participants. Methods A longitudinal study was conducted in 2017-2018 in the form of an online survey. Alcohol consumption characteristics of respondents (N = 125) were measured by the short-form AUDIT test. Participants filled out the first survey at the end of October 2017 with a one-year follow-up questionnaire. We used the reliable change index to identify participants whose c-AUDIT scores changed significantly over time. We collated participants who exhibited no change or significant decrease in c-AUDIT scores into one group, which was used as reference in our logistic regression analyses. We first conducted a series of univariate regression analyses to identify significant confounders, which were then included in the subsequent multivariate regression analysis. Results Based on our results, success rates did not differ significantly between those who exhibited a significant increase in c-AUDIT scores and those whose c-AUDIT scores did not change or decreased significantly over a one-year time period. In our multivariate regression analysis, the occurrence of alcohol consumption in the same household (OR = 3.29, 95% CI: 1.17-10.01) was the only variable significantly associated to an increase in c-AUDIT scores. Conclusions Even though success rate of participation in the 2017 Dry November campaign did not influence c-AUDIT scores significantly at follow-up, we were able to identify the occurrence of alcohol consumption in household as a significant risk factor for those who exhibited a significant increase in c-AUDIT score. Key messages A one-month alcohol-free challenge might be an effective tool for reducing alcohol consumption but further analysis is needed. The inclusion of individuals in the same household in interventions aiming to decrease alcohol intake may lead to higher success rate.

scholarly journals The Diagnosis and Treatment of Low T3 Syndrome in Neurocritical Patients

2019 ◽  
Author(s):  
Yihao Chen ◽  
Jianbo Chang ◽  
Rui Yin ◽  
Junxian Wen ◽  
Baitao Ma ◽  
...  
Keyword(s):  
Overall Survival ◽  
Regression Analysis ◽  
Mortality Risk ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Low T3 Syndrome ◽  
Low T3 ◽  
Significant Difference ◽  
Serum T3

Abstract Background Low serum T3 level is considered as a strong predictor of mortalities and poor prognosis in critical care patients. Few reports, however, focus on neurocritical patients. The application of hormone replacement therapy (HRT) in neurocritical patients with low T3 syndrome also remains controversial. We studied the role of low T3 state as a predictor in neurocritical patients and presented our experience of HRT from a single-center perspective.Methods From January 2012 to October 2018, a total of 32 neurocritical patients with low T3 syndrome were admitted to the neuro-intensive care unit (NICU) of Peking Union Medical College Hospital. Among them, 18 (56.25%) patients received HRT (HRT group) since the diagnosis of low T3 syndrome, while the other 14 (43.75%) patients did not (non-HRT group). We collected the clinical baseline and laboratory data of all the patients and conducted follow-up from 3 to 72 months. Overall survival was assessed by the Kaplan-Meier curve and compared by the log-rank test. Univariate and multivariate regression analysis was applied to estimate the prognostic power of HRT for mortality. We also performed the Mann-Whitney U test or t-test to assess the influence of HRT on the final neurological function.Results The cohort consists of 32 patients, with an average Glasgow Coma Scale (GCS) of 6.41 (HRT=6.44±3.14, non-HRT=6.36±2.06). The neurocritical events include postoperative complications (n=18), traumatic brain injury (n=8), and spontaneous intracerebral hemorrhage (n=6). A total of 15 (46.87%) deaths were recorded (HRT=7, non-HRT=8). In the HRT group, the low T3 situation in 5 patients (33.3%) was corrected and 10 (66.7%) were not. It turns out that the overall survival rate of the non-HRT group was significantly lower than that of the HRT group (P=0.034, 16.445 vs. 47.470 months). The non-HRT group has 3.322 times the mortality risk of the HRT group, according to univariate regression analysis, while the multivariate regression analysis showed no significant difference in mortality risk between the two groups (P=0.087, HR=0.340 95%CI 0.099-1.172). There was no significant difference in the short and long-term effects of HRT on neurological function (short-term GCS P=0.587, long-term GCS P=0.419, long-term GOS P=0.419).Conclusion Low T3 syndrome can significantly influence the prognosis of neurocritical patients. Therefore much attention should be paid to the changes in serum T3 level during treatment. Although it is unclear to what extent can HRT improve the short or long-term outcome of neurological function, it can significantly benefit the survival of neurocritical patients.

scholarly journals Patient-reported outcomes after corrective osteotomy for a symptomatic malunion of the distal radius

2020 ◽  
Vol 102-B (11) ◽  
pp. 1542-1548
Author(s):  
Paul H. C. Stirling ◽  
William M. Oliver ◽  
Huai Ling Tan ◽  
Iain D. M. Brown ◽  
Christopher W. Oliver ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Patient Satisfaction ◽  
Distal Radius ◽  
Multivariate Regression ◽  
Corrective Osteotomy ◽  
Multivariate Regression Analysis ◽  
Ulnar Styloid ◽  
Ulnar Styloid Fracture ◽  
Patient Reported

Aims The primary aim of this study was to describe patient satisfaction and health-related quality of life (HRQoL) following corrective osteotomy for a symptomatic malunion of the distal radius. Methods We retrospectively identified 122 adult patients from a single centre over an eight-year period who had undergone corrective osteotomy for a symptomatic malunion of the distal radius. The primary long-term outcome was the Patient-Rated Wrist Evaluation (PRWE) score. Secondary outcomes included the Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) score, the EQ-5D-5L score, complications, and the Net Promoter Score (NPS). Multivariate regression analysis was used to determine factors associated with the PRWE score. Results Long-term outcomes were available for 89 patients (72%). The mean age was 57 years (SD 15) and 68 were female (76%). The median time from injury to corrective osteotomy was nine months (interquartile range (IQR) 6 to 13). At a mean follow-up of six years (1 to 11) the median PRWE score was 22 (IQR 7 to 40), the median QuickDASH score was 11.4 (IQR 2.3 to 31.8), and the median EQ-5D-5L score was 0.84 (IQR 0.69 to 1). The NPS was 69. Multivariate regression analysis showed that the presence of an associated ulnar styloid fracture was the only significant independent factor associated with a worse PRWE score when adjusting for confounding variables (p = 0.004). Conclusion We found that corrective osteotomy for malunion of the distal radius can result in good functional outcomes and high levels of patient satisfaction. However, the presence of an ulnar styloid fracture may adversely affect function. Level of Evidence: III (cohort study). Cite this article: Bone Joint J 2020;102-B(11):1542–1548.

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