scholarly journals Hyphenation of size exclusion chromatography to native ion mobility mass spectrometry for the analytical characterization of therapeutic antibodies and related products

2018 ◽  
Vol 1086 ◽  
pp. 176-183 ◽  
Author(s):  
Anthony Ehkirch ◽  
Oscar Hernandez-Alba ◽  
Olivier Colas ◽  
Alain Beck ◽  
Davy Guillarme ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Size Exclusion Chromatography ◽  
Ion Mobility ◽  
Size Exclusion ◽  
Ion Mobility Mass Spectrometry ◽  
Therapeutic Antibodies ◽  
Analytical Characterization ◽  
Exclusion Chromatography

scholarly journals Characterization of trimethoprim resistant E. coli dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates

2017 ◽  
Vol 8 (5) ◽  
pp. 4062-4072 ◽  
Author(s):  
Michael Cammarata ◽  
Ross Thyer ◽  
Michael Lombardo ◽  
Amy Anderson ◽  
Dennis Wright ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Size Exclusion Chromatography ◽  
Dihydrofolate Reductase ◽  
Native Mass Spectrometry ◽  
Size Exclusion ◽  
E Coli ◽  
Exclusion Chromatography

Native mass spectrometry, size exclusion chromatography, and kinetic assays were employed to study trimethoprim resistance in E. coli caused by mutations P21L and W30R of dihydrofolate reductase.

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