A delivery system to avoid self-aggregation and to improve in vitro and in vivo skin delivery of a phthalocyanine derivative used in the photodynamic therapy

In this work, the MNP-HSA-PEG-PS@4 complex was obtained and its physicochemical properties were studied. Biological studies have also been conducted. Namely, the ability of the drug to accumulate in CT26 tumor cells in vitro and the kinetics of drug accumulation in the tumor in vivo were studied. Then, the effectiveness of photodynamic therapy was studied under different conditions. The maximum therapeutic effect was achieved with irradiation at 1 hour after injection of the drug.

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A folic acid conjugated polyethylenimine-modified PEGylated nanographene loaded photosensitizer: photodynamic therapy and toxicity studies in vitro and in vivo

Journal of Materials Chemistry B ◽

10.1039/c6tb00108d ◽

2016 ◽

Vol 4 (12) ◽

pp. 2190-2198 ◽

Cited By ~ 10

Author(s):

Yi-Ping Zeng ◽

Sheng-Lin Luo ◽

Zhang-You Yang ◽

Jia-Wei Huang ◽

Hong Li ◽

...

Keyword(s):

Photodynamic Therapy ◽

Folic Acid ◽

Delivery System ◽

Tumor Targeting ◽

Therapy Efficacy ◽

Toxicity Studies ◽

Targeting Delivery

A novel nanographene-based tumor-targeting delivery system has high photodynamic therapy efficacy with no obvious toxicity and could potentially be utilized in biomedicine.

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Using chitosan gels as a toluidine blue O delivery system for photodynamic therapy of buccal cancer: In vitro and in vivo studies

Photodiagnosis and Photodynamic Therapy ◽

10.1016/j.pdpdt.2014.11.003 ◽

2015 ◽

Vol 12 (1) ◽

pp. 98-107 ◽

Cited By ~ 29

Author(s):

Thierllen Barroso Graciano ◽

Tatielle Soares Coutinho ◽

Camila Beatriz Cressoni ◽

Cristhiane de Paula Freitas ◽

Maria Bernadete Riemma Pierre ◽

...

Keyword(s):

Photodynamic Therapy ◽

Delivery System ◽

Toluidine Blue ◽

In Vivo Studies

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A tumoral acidic pH-responsive drug delivery system based on a novel photosensitizer (fullerene) for in vitro and in vivo chemo-photodynamic therapy

Acta Biomaterialia ◽

10.1016/j.actbio.2013.10.037 ◽

2014 ◽

Vol 10 (3) ◽

pp. 1280-1291 ◽

Cited By ~ 78

Author(s):

Jinjin Shi ◽

Yan Liu ◽

Lei Wang ◽

Jun Gao ◽

Jing Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Photodynamic Therapy ◽

Drug Delivery System ◽

Delivery System ◽

Acidic Ph ◽

Ph Responsive

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A Novel Intravaginal Delivery System for Itraconazole: In Vitro and In Vivo Evaluation

Current Drug Delivery ◽

10.2174/156720109787846289 ◽

2009 ◽

Vol 6 (2) ◽

pp. 151-158 ◽

Cited By ~ 2

Author(s):

N. Dobaria ◽

R. Mashru ◽

A. Badhan ◽

A. Thakkar

Keyword(s):

Delivery System ◽

In Vivo Evaluation ◽

Intravaginal Delivery

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FORMULATION AND IN VITRO, IN VIVO EVALUATION OF PRONIOSOMAL GEL OF NEOMYCIN SULPHATE

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2019v11i2.30614 ◽

2019 ◽

pp. 156-163

Author(s):

AMOL SHETE ◽

PRIYANKA THORAT ◽

RAJENDRA DOIJAD ◽

SACHIN SAJANE

Keyword(s):

Phase Separation ◽

Skin Irritation ◽

Entrapment Efficiency ◽

Separation Method ◽

Gelling Agent ◽

In Vivo Evaluation ◽

Skin Delivery ◽

Span 60

Objective: The objectives of present investigation were to prepare and evaluate proniosomes of neomycin sulphate (NS) by coacervation phase separation method by using sorbitan monostearate (span 60) and lecithin as a surfactant to increase the penetration through the skin and study the effect of concentration of the same. Methods: Proniosomes of neomycin sulphate (NS) were prepared by coacervation phase separation method by using span 60 and lecithin. The effect of concentration of span 60 and lecithin was studied by factorial design. The prepared proniosomes were converted to gel by using carbopol as a gelling agent. The prepared formulations were evaluated for entrapment efficiency, in vitro drug diffusion, in vitro antibacterial activity and in vivo skin irritation test etc. Results: All Formulation showed the percentage entrapment efficiency in the range 38.31±0.05% to 77.96±0.06%, good homogeneity and gel was easily spreadable with minimal of shear. Optimized formulation showed enhanced rate of diffusion in vitro, increase in zone of inhibition against staphylococcus aureus, no skin irritation and showed good stability. Conclusion: The results of present study indicates that proniosomal gel formulated by using combination of span 60, Lecithin, cholesterol can be used to enhance skin delivery of NS because of excellent permeation of drug. Developed proniosomal gel formulation was promising carrier for NS

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Development of Triamcinolone Acetonide-Loaded Microemulsion as a Prospective Ophthalmic Delivery System for Treatment of Uveitis: In Vitro and In Vivo Evaluation

Pharmaceutics ◽

10.3390/pharmaceutics13040444 ◽

2021 ◽

Vol 13 (4) ◽

pp. 444

Author(s):

Alaa Mahran ◽

Sayed Ismail ◽

Ayat A. Allam

Keyword(s):

Triamcinolone Acetonide ◽

Delivery System ◽

Histopathological Examination ◽

Rabbit Model ◽

Subconjunctival Injection ◽

In Vivo Evaluation ◽

Ternary Phase Diagrams ◽

Ophthalmic Delivery

Treatment of uveitis (i.e., inflammation of the uvea) is challenging due to lack of convenient ophthalmic dosage forms. This work is aimed to determine the efficiency of triamcinolone acetonide (TA)-loaded microemulsion as an ophthalmic delivery system for the treatment of uveitis. Water titration method was used to construct different pseudo-ternary phase diagrams. Twelve microemulsion formulations were prepared using oleic acid, Cremophor EL, and propylene glycol. Among all tested formulations, Formulation F3, composed of oil: surfactant-co-surfactant (1:1): water (15:35:50% w/w, respectively), was found to be stable and showed acceptable pH, viscosity, conductivity, droplet size (211 ± 1.4 nm), and zeta potential (−25 ± 1.7 mV) and almost complete in vitro drug release within 24 h. The in vivo performance of the optimized formulation was evaluated in experimentally uveitis-induced rabbit model and compared with a commercial TA suspension (i.e., Kenacort®-A) either topically or by subconjunctival injection. Ocular inflammation was evaluated by clinical examination, white blood cell count, protein content measurement, and histopathological examination. The developed TA-loaded microemulsion showed superior therapeutic efficiency in the treatment of uveitis with high patient compliance compared to commercial suspension. Hence, it could be considered as a potential ocular treatment option in controlling of uveitis.

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Synthesis and Characterization of Polyvinylpyrrolidone-Modified ZnO Quantum Dots and Their In Vitro Photodynamic Tumor Suppressive Action

International Journal of Molecular Sciences ◽

10.3390/ijms22158106 ◽

2021 ◽

Vol 22 (15) ◽

pp. 8106

Author(s):

Tianming Song ◽

Yawei Qu ◽

Zhe Ren ◽

Shuang Yu ◽

Mingjian Sun ◽

...

Keyword(s):

Quantum Dots ◽

Photodynamic Therapy ◽

Inhibitory Effect ◽

Therapeutic Effects ◽

In Vivo Experiments ◽

Potential Applications ◽

Zno Quantum Dots ◽

Zno Qds

Despite the numerous available treatments for cancer, many patients succumb to side effects and reoccurrence. Zinc oxide (ZnO) quantum dots (QDs) are inexpensive inorganic nanomaterials with potential applications in photodynamic therapy. To verify the photoluminescence of ZnO QDs and determine their inhibitory effect on tumors, we synthesized and characterized ZnO QDs modified with polyvinylpyrrolidone. The photoluminescent properties and reactive oxygen species levels of these ZnO/PVP QDs were also measured. Finally, in vitro and in vivo experiments were performed to test their photodynamic therapeutic effects in SW480 cancer cells and female nude mice. Our results indicate that the ZnO QDs had good photoluminescence and exerted an obvious inhibitory effect on SW480 tumor cells. These findings illustrate the potential applications of ZnO QDs in the fields of photoluminescence and photodynamic therapy.

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