scholarly journals Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

2016 ◽  
Vol 235 ◽  
pp. 34-47 ◽  
Author(s):  
Cláudia Saraiva ◽  
Catarina Praça ◽  
Raquel Ferreira ◽  
Tiago Santos ◽  
Lino Ferreira ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Neurodegenerative Diseases ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Brain Drug Delivery ◽  
Blood Brain

Brain Drug Delivery: Overcoming the Blood-brain Barrier to Treat Tauopathies

2020 ◽  
Vol 26 (13) ◽  
pp. 1448-1465 ◽  
Author(s):  
Jozef Hanes ◽  
Eva Dobakova ◽  
Petra Majerova
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Neurodegenerative Disorders ◽  
Brain Barrier ◽  
Neuronal Function ◽  
Brain Drug Delivery ◽  
Naturally Occurring ◽  
Blood Brain ◽  
Traditional Approaches ◽  
The Brain

Tauopathies are neurodegenerative disorders characterized by the deposition of abnormal tau protein in the brain. The application of potentially effective therapeutics for their successful treatment is hampered by the presence of a naturally occurring brain protection layer called the blood-brain barrier (BBB). BBB represents one of the biggest challenges in the development of therapeutics for central nervous system (CNS) disorders, where sufficient BBB penetration is inevitable. BBB is a heavily restricting barrier regulating the movement of molecules, ions, and cells between the blood and the CNS to secure proper neuronal function and protect the CNS from dangerous substances and processes. Yet, these natural functions possessed by BBB represent a great hurdle for brain drug delivery. This review is concentrated on summarizing the available methods and approaches for effective therapeutics’ delivery through the BBB to treat neurodegenerative disorders with a focus on tauopathies. It describes the traditional approaches but also new nanotechnology strategies emerging with advanced medical techniques. Their limitations and benefits are discussed.

The Blood-Brain Barrier and Brain Drug Delivery

2006 ◽  
Vol 6 (9) ◽  
pp. 2712-2735 ◽  
Author(s):  
J. M. Koziara ◽  
P. R. Lockman ◽  
D. D. Allen ◽  
R. J. Mumper
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Present Report ◽  
Drug Carriers ◽  
Brain Barrier ◽  
Brain Targeting ◽  
Anatomy And Physiology ◽  
Brain Drug Delivery ◽  
Blood Brain

The present report encompasses a thorough review of drug delivery to the brain with a particular focus on using drug carriers such as liposomes and nanoparticles. Challenges in brain drug delivery arise from the presence of one of the strictest barriers in vivo—the blood-brain barrier (BBB). This barrier exists at the level of endothelial cells of brain vasculature and its role is to maintain brain homeostasis. To better understand the principles of brain drug delivery, relevant knowledge of the blood-brain barrier anatomy and physiology is briefly reviewed. Several approaches to overcome the BBB have been reviewed including the use of carrier systems. In addition, strategies to enhance brain drug delivery by specific brain targeting are discussed.

Gemini quaternary ammonium-incorporated biodegradable multiblock polyurethane micelles for brain drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (8) ◽  
pp. 6160-6171 ◽  
Author(s):  
Rui-Chao Liang ◽  
Fang Fang ◽  
Yan-Chao Wang ◽  
Ni-Jia Song ◽  
Jie-Hua Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Quaternary Ammonium ◽  
Drug Accumulation ◽  
Brain Barrier ◽  
Brain Drug Delivery ◽  
Blood Brain

Gemini quaternary ammonium (GQA) incorporated biodegradable multiblock polyurethane (BMPUs) micelles could transport drug across blood–brain barrier and improve brain drug accumulation.

Stimulating brain drug delivery

2020 ◽  
Vol 12 (564) ◽  
pp. eabe8119
Author(s):  
Raag Airan
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Neural Activity ◽  
Brain Barrier ◽  
Brain Drug Delivery ◽  
Blood Brain ◽  
The Central Nervous System

Neural activity affects how the blood-brain barrier regulates influx and efflux of agents between the blood and the central nervous system.

scholarly journals Blood–brain barrier and laser technology for drug brain delivery

2017 ◽  
Vol 10 (05) ◽  
pp. 1730011 ◽  
Author(s):  
Oxana V. Semyachkina-Glushkovskaya ◽  
Arkady S. Abdurashitov ◽  
Elena I. Saranceva ◽  
Eketerina G. Borisova ◽  
Alexander A. Shirokov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Surgical Navigation ◽  
Normal Function ◽  
Brain Barrier ◽  
Protective Mechanism ◽  
Clinical Method ◽  
Brain Drug Delivery ◽  
Blood Brain ◽  
The Brain

Here, we discuss an important problem in medicine as development of effective strategies for brain drug delivery. This problem is related to the blood–brain barrier (BBB), which is a “customs” controlling the entrance of different molecules from blood into the brain protecting the normal function of central nervous system (CNS). We show three interfaces of anatomical side of BBB and two functional types of BBB — physical and transporter barriers. Although this protective mechanism is essential for health of CNS, it also creates a hindrance to the entry of drugs into the brain. The BBB was discovered over 100 years ago but till now, there is no effective methods for brain drug delivery. There are more than 70 approaches for overcoming BBB including physical, chemical and biological techniques but all of these tools have limitation to be widely used in clinical practice due to invasiveness, challenge in performing, very costly or limitation of drug concentration.Photodynamic therapy (PDT) is usual clinical method of surgical navigation for the resection of brain tumor and anti-cancer therapy. Nowadays, the application of PDT is considered as a potential promising tool for brain drug delivery via opening of BBB. Here, we show the first successful experimental results in this field discussing the adventures and disadvantages of PDT-related BBB disruption as well as alternatives to overcome these limitations and possible mechanisms with new pathways for brain clearance via glymphatic and lymphatic systems.

scholarly journals Innovative approach for nasal drug delivery system for brain target

2021 ◽  
Vol 9 (3) ◽  
pp. 093-106
Author(s):  
Priyadarshani G Patil ◽  
Sampada V Marodkar ◽  
Sachin J Dighade ◽  
Prajakta N Dongare ◽  
Bhagyashri A Borade
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Blood Brain Barrier ◽  
Delivery System ◽  
Drug Transport ◽  
Nasal Delivery ◽  
Brain Barrier ◽  
Non Invasive ◽  
Brain Drug Delivery ◽  
Blood Brain

The goal of brain drug targeting technology is the delivery of therapeutics across the blood brain barrier (BBB), including the human BBB. Nose to brain drug delivery has received a great deal of attention as a non- invasive, convenient and reliable drug delivery system. For the systemic and targetedadministration of drug. The various drug deliveries through some drug transport pathways, Factor influencing nasal drug absorption, formulation strategies nose to brain, colloidal carriers in nose to brain drug delivery system and nasal delivery systems. Physiological barriers (BBB) that restricts the delivery of drug to CNS. Thus intranasal route has attracted a wide attention of convenient, non-invasive, reliable, and safe route to achieve faster and higher level of drug in the brain through olfactory region by passing blood brain barrier. Intranasal administration rapid onset of action, no first –pass effect , no gastrointestinal degradation lungs toxicity and non-invasiveness application and also improves bioavailability.

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