scholarly journals Combination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapy

2017 ◽  
Vol 263 ◽  
pp. 223-230 ◽  
Author(s):  
Jihoon Kim ◽  
Bryant C. Yung ◽  
Won Jong Kim ◽  
Xiaoyuan Chen
Keyword(s):  
Nitric Oxide ◽  
Drug Delivery ◽  
Drug Resistance ◽  
Drug Delivery Systems ◽  
Delivery Systems

Nanoparticle-based drug delivery systems with platinum drugs for overcoming cancer drug resistance

2021 ◽  
Author(s):  
Peng Xie ◽  
Yushu Wang ◽  
Dengshuai Wei ◽  
Lingpu Zhang ◽  
Bin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Platinum Drugs ◽  
Effective Strategy ◽  
Platinum Drug ◽  
Cancer Drug Resistance ◽  
Platinum Drug Resistance

The mechanisms of chemoresistance and nanoparticle-based drug delivery systems for platinum drugs were detailed summarized in this review. The current combination therapy provided an effective strategy to overcome the platinum drug resistance.

Nitric oxide-sensing actuators for modulating structure in lipid-based liquid crystalline drug delivery systems

2017 ◽  
Vol 508 ◽  
pp. 517-524 ◽  
Author(s):  
Qingtao Liu ◽  
Jinming Hu ◽  
Michael R. Whittaker ◽  
Thomas P. Davis ◽  
Ben J. Boyd
Keyword(s):  
Nitric Oxide ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Liquid Crystalline ◽  
Delivery Systems

Use of Anticancer Platinum Compounds in Combination Therapies and Challenges in Drug Delivery

2020 ◽  
Vol 27 (18) ◽  
pp. 3055-3078 ◽  
Author(s):  
Xiao Xiao ◽  
James Trevor Oswald ◽  
Ting Wang ◽  
Weina Zhang ◽  
Wenliang Li
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Acquired Drug Resistance ◽  
Safe Delivery ◽  
Combinational Therapy ◽  
Solid Malignancies ◽  
Tumor Drugs

As one of the leading and most important metal-based drugs, platinum-based pharmaceuticals are widely used in the treatment of solid malignancies. Despite significant side effects and acquired drug resistance have limited their clinical applications, platinum has shown strong inhibitory effects for a wide assortment of tumors. Drug delivery systems using emerging technologies such as liposomes, dendrimers, polymers, nanotubes and other nanocompositions, all show promise for the safe delivery of platinum-based compounds. Due to the specificity of nano-formulations; unwanted side-effects and drug resistance can be largely averted. In addition, combinational therapy has been shown to be an effective way to improve the efficacy of platinum based anti-tumor drugs. This review first introduces drug delivery systems used for platinum and combinational therapeutic delivery. Then we highlight some of the recent advances in the field of drug delivery for combinational therapy; specifically progress in leveraging the cytotoxic nature of platinum-based drugs, the combinational effect of other drugs with platinum, while evaluating the drug targeting, side effect reducing and sitespecific nature of nanotechnology-based delivery platforms.

scholarly journals Perspectives of nano-carrier drug delivery systems to overcome cancer drug resistance in the clinics

2021 ◽  
Author(s):  
Anna Ulldemolins ◽  
Joaquin Seras-Franzoso ◽  
Fernanda Andrade ◽  
Diana Rafael ◽  
Ibane Abasolo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Cancer Drug Resistance

Drug resistance in leishmaniasis: current drug-delivery systems and future perspectives

2013 ◽  
Vol 5 (15) ◽  
pp. 1877-1888 ◽  
Author(s):  
Masoom Yasinzai ◽  
Momin Khan ◽  
Akhtar Nadhman ◽  
Gul Shahnaz
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Future Perspectives ◽  
Current Drug

scholarly journals Drug Release Studies of SC-514 PLGA Nanoparticles

2021 ◽  
pp. 1-21
Author(s):  
Famuyiwa Toluleke Oloruntobi ◽  
Bowers Zoey ◽  
Bentley Austin ◽  
Caraballo Davian ◽  
Subtil Paulynice ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Drug Resistance ◽  
Drug Release ◽  
Tumor Growth ◽  
Drug Delivery Systems ◽  
Plga Nanoparticles ◽  
Delivery Systems ◽  
New Methods ◽  
Coated Nanoparticles

A major problem associated with prostate cancer treatment is the development of drug resistance. The development of drug resistance often leads to prostate cancer metastasis and prostate cancer-targeted drug delivery systems can be utilized to address this problem. Traditional drug delivery systems have many challenges, including the inability to control the drug release rate, target site inaccuracy, susceptibility to the microenvironment, poor drug solubility, and cytotoxicity of chemotherapeutics to non-malignant cells. As a result, there is an urgent need to formulate and functionalize a drug delivery system that better controls drug release. This study was designed to quantify the release of SC-514 from SC-514 Polylactic-Co-Glycolic Acid (PLGA) nanoparticles and conjugate SC-514-PLGA coated nanoparticles with the NF- κβ antibody, as well as fats. This study further explored new methods to quantify the release of SC-514 drug from the SC-514-PLGA coated nanoparticles after utilizing Liquid Chromatography–Mass Spectrometry (LC-MS) as the standard method to quantify SC-514 drug released. After quantification was completed, cell viability studies indicated that the ligand conjugated nanoparticles demonstrated a considerable ability to reduce tumor growth and SC-514 drug toxicity in the PC-3 cell line. The prepared drug delivery systems also possessed a significantly lower toxicity (P<0.05), bettered controlled-release behaviors in prostate cancer, and increased the solubility of SC-514 in comparison to free SC-514. SC-514 released from SC-514-PLGA, SC-514-PLGA-NF- κβAb, and SC-514-PLGA-Fat nanoparticles, significantly inhibited tumor growth when compared to that of free SC-514. The anti-cancer therapeutic effects of SC-514 were improved through the encapsulation of SC-514 with a PLGA polymer. The functionalized SC-514-PLGA nanoparticles can further control burst release. The new methods utilized in this study for quantifying drug release, may prove to be as effective as the current standard methods, such as LC/MS.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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