Anti-theodicy narrative in the novel “Vadim” of M.Yu. Lermontovова

“Vadim” is the first experience of Mikhail Lermontov in prose. Some Russian scholars define it as ahistorical novel. The combination of themes of individual revenge with the theme of peasant revolt is a peculiar feature of “Vadim”. The author of the novel raises the question of the origin of evil, presupposed by “heocracy”, and by analyzing the hero Vadim’s revenge motive, the anti-theodicy’s narrative mechanism of the novel can be explained. The scene in which the hero abets his companion to hang the captured old man is a direct experiment of anti- theodicy and a powerful testimony of the writer's anti- theodicy standpoint. According to Leibniz’s theory, Vadim's evil belongs to moral evil. Lermontov’s view of good and evil echoes Leibniz’s theory. Leibniz believes that evil exists to show good and make it the object of opposition, and that man can achieve perfection in the process of winning good over evil. From the novel two righteous images — the nameless old man and the wife of a soldier, persisted in their beliefs in times of crisis, which showed the writer’s inheritance of theodicy’s standpoint. Before hanging, the nameless old man recalls the death of Jesus Christ and at the last moment of his life still believed that Jesus had conquered death. The scene of the torture of a soldier’s wife resembles the “martyrdom of the righteous”. For the truth, for what she believes, she is willing to sacrifice herself. This is the proof of the two repeated verses in the novel: “Come to me all you who labor and are burdened, and I will give you rest”. Lermontov’s theological view in “Vadim” is paradoxical.

THE USE OF BENFORD’S LAW IN PERFORMANCE AUDIT TO DETECT FRAUD IN THE STATE EXPENDITURETRANSACTIONS ASSISTED BY IDEA SOFTWARE (A Case Study at the Transportation Ministry Work Units)

The aim ofthis study was to determine the use of Benford's Law in Performance Audits todetect fraudin state expenditure transactions assisted by IDEA Software,a case studyat several Work Units of the Ministry of Transportation. The research method used was descriptive qualitative and direct experiment. This researchwas conucted while the researcher wascarruing outperformance auditat three work units of the Ministry of Transportation. The researcher used IDEA Software to analyze the financial transaction data according to Benford's law. Based on the results of the research, the right type of state expenditure to be analyzed using Benford law isgoods expenditure.In addition,Benford’s Law can be used in performance audits to determinestate expenditure transactions that are indicated fraud with the success rate of ranging from 20% to 50%t. Transactions that appear are not in accordance with Benford's law.

Enhanced C/EBPs binding to C>T mismatches facilitates fixation of CpG mutations

Knowledge of mechanisms responsible for mutagenesis of adult stem cells is crucial to track genomic alterations that may affect cell renovation and provoke malignant cell transformation. Mutations in regulatory regions are widely studied nowadays, though mostly in cancer. In this study, we decomposed the mutation signature of adult stem cells, mapped the corresponding mutations into transcription factor binding regions, and assessed mutation frequency in sequence motif occurrences. We found binding sites of C/EBP transcription factors strongly enriched with [C>T]G mutations within the core CG dinucleotide related to deamination of the methylated cytosine. This effect was also exhibited in related cancer samples. Structural modeling predicted enhanced CEBPB binding to the consensus sequence with the [C>T]G mismatch, which was then confirmed in the direct experiment. We propose that it is the enhanced binding of C/EBPs that shields C>T transitions from DNA repair and leads to selective accumulation of the [C>T]G mutations within binding sites.

AN EXPERIMENTAL STUDY OF THE PENETRATION OF CYLINDRICAL PROJECTILES INTO DRY SAND

For the most complete study of the laws of shock interaction of solids with soil barriers, further development of experimental techniques for recording the parameters of the interaction process in direct and inverse experiments is necessary. In this work, to determine the parameters of the movement of the projectile (displacement and speed) in a direct experiment, a millimeter-wave radio interferometer is used. This method allows continuous recording of the movement of the rear end of the striker with high accuracy over a wide range of movements. Using the proposed technique, experiments were carried out to record the motion parameters of cylindrical impactors made of steel and aluminum alloy when interacting with an obstacle made of dry sand. At the same time, the movement of the rear end of the striker was also controlled using high-speed filming until the full immersion of the striker. The experiments showed that the measurement results obtained using two methods coincide within the measurement error. Based on the experiments, it can be concluded that the methodology for determining the displacement and velocity of a projectile in a ballistic experiment using a millimeter-wave radio interferometer allows continuous measurement of large displacements (100 mm or more), including when completely immersed in a target with sufficient practical goals accuracy. Based on the results of the experiments, the dependences of the movement of the projectile and its speed on time are constructed. A change in the penetration law was found with a decrease in the penetration velocity to values less than 100 m/s.

Investigation on the Influence of Microstructure Based on Hydrogen Bonding on Surface Tension by Raman Spectroscopy

Surface tension (http://mts.hindawi.com/update/) in our Manuscript Tracking System and after you have logged in click on the ORCID link at the top of the page. This link will take you to the ORCID website where you will be able to create an account for yourself. Once you have done so, your new ORCID will be saved in our Manuscript Tracking System automatically."?>and Raman spectra containing hydrogen bonding in acetonitrile aqueous solutions with different mole ratios were obtained. Varied surface tension and hydrogen bonding in the mixed solution were discussed. For this purpose, the OH stretching bands were fitted into three Gaussian components to which different hydrogen-bonded water samples were assigned. Furthermore, the microstructures of binary solution were analyzed. The results indicated that the surface tension decreases dramatically with the enhancement of hydrogen bonds in the mixture. A spectroscopic method for studying the macroscopic properties of aqueous solutions was employed. The direct experiment results provided the relationship between surface tension and microstructure in aqueous solutions.

Whether the Validation of the Predictive Potential of Toxicity Models is a Solved Task?

Different kinds of biological activities are defined by complex biochemical interactions, which are termed as a "mathematical function" not only of the molecular structure but also for some additional circumstances, such as physicochemical conditions, interactions via energy and information effects between a substance and organisms, organs, cells. These circumstances lead to the great complexity of prediction for biochemical endpoints, since all "details" of corresponding phenomena are practically unavailable for the accurate registration and analysis. Researchers have not a possibility to carry out and analyse all possible ways of the biochemical interactions, which define toxicological or therapeutically attractive effects via direct experiment. Consequently, a compromise, i.e. the development of predictive models of the above phenomena, becomes necessary. However, the estimation of the predictive potential of these models remains a task that is solved only partially. This mini-review presents a collection of attempts to be used for the above-mentioned task, two special statistical indices are proposed, which may be a measure of the predictive potential of models. These indices are (i) Index of Ideality of Correlation; and (ii) Correlation Contradiction Index.

CHARACTERISTIC OF MUS-01 WING’S STRUCTURE TESTING MODEL

The characteristic model of MUS-01 wing structure testing has been performed. Planned, this model will be used as an unmanned wing of the LSU-03NG. The test model is made of composite type e-glass. At the time of testing the structure test model is loaded according to MTOW weight. This research method also involves the unmanned aircraft mission, especially on the model test structure, model dimension, and direct experiment in the form of loading on the test model. The result of characterization of the test model during test, showed that the indicated test model has the characteristics as a test model that is unable to accept the unmanned operational load of LSU-03NG series aircraft. So it can not be used as a consideration for the structure of the unmanned aircraft.

Identification of the Conceptual Understanding of the Uniformly Accelerated Rectilinear Motion (GLBB) Material Using PhET Application and the VAK Learning Model among Junior High School Students

Junior high school students find it difficult to understand the materials and the concepts in science learning because the teaching method that is too monotonous. It is the lecturing method where students are less involved in learning activities, and this has led to the decline in students’ learning outcomes in science learning. The use of media and learning models play an important role. The popular media in learning are modern media, in this case PhET application. This application can give the impression of a direct experiment among students without ignoring technological developments where IT is needed by students. This study aims to identify students' conceptions on concepts. The type of this research was a library research. This study used the VAK learning model (Visual, Auditory, and Kinesthetic). In the VAK learning model, the teacher can combine three teaching-learning styles. 1) The teacher will prioritize the demonstration or the media by showing the teaching tools directly to the students and describing them on the board. 2) In learning by listening, the teacher must be able to explain clearly and in detail so that the students can understand the material presented. 3) In learning practice, after the students listen and learn through physical activity and direct involvement, they must conduct a direct experiment to gain deeper understanding of the materials. In this library research, the researchers searched for some references related to the research.

An inhibitor-interaction intermediate of HIV-1 protease, revealed by Isothermal Titration Calorimetry and NMR spectroscopy

Some of drug-resistant mutants of HIV-1 protease (PR), such as a clinically-relevant drug- resistant PR mutant (Flap+(I54V)) containing L10I, G48V, I54V and V82A mutations, produce significant changes in the balance between entropy and enthalpy of the drug-PR interactions, compared to the wild-type (WT) PR. Here, to gain a comprehensive understanding of the entropy-enthalpy compensation effects, we compared nuclear magnetic resonance (NMR), fluorescence spectroscopy and isothermal titration calorimetry (ITC) data of a WT PR with Flap+(I54V)and related mutants: (1) Flap+(I54V); (2) Flap+(I54A)which evolves from Flap+(I54V)in the continued presence of inhibitor yet does not exhibit entropy-enthalpy compensation; and (3) Flap+(I54), a control mutant that contains only L10I, G48V and V82A mutations. Our data indicate that WT and Flap+(I54A)show enthalpy-driven inhibitor-interaction, while Flap+(I54)and Flap+(I54V)exhibit entropy-driven inhibitor interaction. Interestingly, Flap+(I54A)exhibited significantly slower heat flow in the competitive ITC experiment with a strong binder, darunavir, and a weak binder, acetyl-pepstatin, but did not exhibit such slow heat flow in the direct inhibitor-titration experiments. NMR confirmed replacement of the weak binder by the strong binder in a competitive manner. This difference in the heat flow of the competitive binding experiment compared to the direct experiment can only be explained by assuming an inhibitor-bound intermediate pathway. A similar, but attenuated, tendency for slow heat flow was also detected in the competitive experiment with WT. Overall, our data suggests that an inhibitor-bound intermediate affects the entropy-enthalpy compensation of inhibitor-PR interaction.

Agerelated dynamics of elasticity of deep dorsal vein of human penis according to results of direct measurements

Background. An important role in the mechanism of the development and support of erection is assigned to the venous system of penis. At the same time, diacrisis and surgical correction of the disordered venous drainage is not successful in all cases. The rate of erection disorders is associated with various factors, but progressively grows with the age. Aim. To define the agerelated dynamics of flexibility of the major venous vessel of penis – a deep dorsal vein – in a direct experiment. Materials and methods. Research was conducted on samples of a deep dorsal vein of penis obtained in autopsy of 30 males who have died suddenly from injuries or acute diseases at the age from 18 to 83 years. A deep dorsal vein of penis was isolated by an acute method without surrounding tissues. A fragment of the vein 2.53.5 cm in length was isolated distally the retaining ligament used as a reference point. In the course of experiments samples of veins were exposed to discretely increasing stretching force in the longitudinal direction with fixation of the corresponding absolute increments in the length on a specially designed installation using the original technique. Results. The mathematical analysis of the results of direct measurements of elastic properties of the studied vein permitted to reveal a considerable – about 20% – reduction in the elasticity of the vein in the studied age range 18 years – 83 years from α0 = 6,2∙108 m2/N to α0 = 5,0∙108 m2/N. With increase in the force of load, the average value of vein elasticity rapidly declined, and asymptotically approached the established value of the order of α = 1,4∙108 m2/N. Here, the agerelated tendency to reduction in the elasticity with different degree of the functional load persists. Conclusion. The identified regularities of decline in the elasticity reflect changes in the wall of a deep dorsal vein with age that may play a role in the agerelated increase in the rate of erectile dysfunction. The applied method of determination of elasticity can be used for determination of elasticity of vessels of other localizations and also of some other biological tissues in norm and pathology.