A novel transplatin(IV) prodrugs and its drug delivery system for overcoming drug resistance

2017 ◽  
Vol 259 ◽  
pp. e142
Author(s):  
Wenliang Li ◽  
Mo Jiang ◽  
Rong Du ◽  
Xiaoguang Yang ◽  
Leijiao Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Drug Delivery System ◽  
Delivery System

scholarly journals Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance

2015 ◽  
Vol 112 (10) ◽  
pp. 2978-2983 ◽  
Author(s):  
Tuo Wei ◽  
Chao Chen ◽  
Juan Liu ◽  
Cheng Liu ◽  
Paola Posocco ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Drug Carrier ◽  
Drug Loading ◽  
Cancer Drug ◽  
Self Assembling

Drug resistance and toxicity constitute challenging hurdles for cancer therapy. The application of nanotechnology for anticancer drug delivery is expected to address these issues and bring new hope for cancer treatment. In this context, we established an original nanomicellar drug delivery system based on an amphiphilic dendrimer (AmDM), which could generate supramolecular micelles to effectively encapsulate the anticancer drug doxorubicin (DOX) with high drug-loading capacity (>40%), thanks to the unique dendritic structure creating large void space for drug accommodation. The resulting AmDM/DOX nanomicelles were able to enhance drug potency and combat doxorubicin resistance in breast cancer models by significantly enhancing cellular uptake while considerably decreasing efflux of the drug. In addition, the AmDM/DOX nanoparticles abolished significantly the toxicity related to the free drug. Collectively, our studies demonstrate that the drug delivery system based on nanomicelles formed with the self-assembling amphiphilic dendrimer constitutes a promising and effective drug carrier in cancer therapy.

A self-assembled albumin based multiple drug delivery nanosystem to overcome multidrug resistance

RSC Advances ◽  
2015 ◽  
Vol 5 (9) ◽  
pp. 6807-6814 ◽  
Author(s):  
Bin Chen ◽  
Cong Wu ◽  
Ren-Xi Zhuo ◽  
Si-Xue Cheng
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Multidrug Resistance ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multiple Drug ◽  
Self Assembled ◽  
Multiple Drug Delivery

A self-assembled nano-sized albumin based drug delivery system co-loaded with an anti-tumor drug and a drug resistance inhibitor has promising applications in overcoming multidrug resistance (MDR).

Nanoliposomal multi-drug delivery system with reduced toxicity and multi-drug resistance

2019 ◽  
Vol 54 (13) ◽  
pp. 9718-9728 ◽  
Author(s):  
Jing Yang ◽  
Chiyu Wen ◽  
Chao Pan ◽  
Hongshuang Guo ◽  
Weiqiang Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multi Drug Resistance ◽  
Reduced Toxicity

Overcoming drug resistance with functional mesoporous titanium dioxide nanoparticles combining targeting, drug delivery and photodynamic therapy

2018 ◽  
Vol 6 (46) ◽  
pp. 7750-7759 ◽  
Author(s):  
Zhaoming Guo ◽  
Kun Zheng ◽  
Zhenquan Tan ◽  
Ye Liu ◽  
Ziyin Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Titanium Dioxide ◽  
Photodynamic Therapy ◽  
Tumor Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Titanium Dioxide Nanoparticles ◽  
Nano Drug Delivery ◽  
Targeting Strategy

We have designed a nano-drug delivery system ADH-1-HA-MTN, which can overcome the drug resistance of tumor cells based on an EMT cell targeting strategy in combination with PDT.

PTX encapsulated by an XG–DOX conjugate for combination therapy against multi-drug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (109) ◽  
pp. 107606-107612 ◽  
Author(s):  
Zhuli Huang ◽  
Xuan Xie ◽  
Jean Felix Mukerabigwi ◽  
Chang Wang ◽  
Shufang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Combination Therapy ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multi Drug Resistance ◽  
New Type ◽  
Dual Drug

A new type of targeted dual drug delivery system was designed and possesses outstanding advantages over ordinary systems, proving effective against MDR cancer cells.

Dual drug delivery system of PLGA nanoparticles to reverse drug resistance by altering BAX/Bcl-2

2018 ◽  
Vol 47 ◽  
pp. 291-298 ◽  
Author(s):  
Farhad Alvandifar ◽  
Baharnaz Ghaffari ◽  
Navid Goodarzi ◽  
Nazanin Shabani Ravari ◽  
Fahimeh Karami ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Drug Delivery System ◽  
Delivery System ◽  
Plga Nanoparticles ◽  
Dual Drug
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