Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies

2020 ◽  
Vol 327 ◽  
pp. 316-349 ◽  
Author(s):  
Farshad Moradi Kashkooli ◽  
M. Soltani ◽  
Mohammad Souri
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Nano Drug Delivery ◽  
Anti Cancer

Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

2018 ◽  
Vol 18 (10) ◽  
pp. 857-880 ◽  
Author(s):  
Salma E. Ahmed ◽  
Nahid Awad ◽  
Vinod Paul ◽  
Hesham G. Moussa ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Special Focus ◽  
Nano Drug Delivery ◽  
Medical Researchers ◽  
History Of ◽  
Overall Performance ◽  
Enhanced Stability

Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

New folate-functionalized biocompatible block copolymer micelles as potential anti-cancer drug delivery systems

Polymer ◽  
2006 ◽  
Vol 47 (9) ◽  
pp. 2946-2955 ◽  
Author(s):  
Mariano Licciardi ◽  
Gaetano Giammona ◽  
Jianzhong Du ◽  
Steven P. Armes ◽  
Yiqing Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Cancer Drug Delivery

scholarly journals Perspectives in Engineered Mesenchymal Stem/Stromal Cells Based Anti- Cancer Drug Delivery Systems

2016 ◽  
Vol 11 (1) ◽  
pp. 98-111 ◽  
Author(s):  
Darinka Gjorgieva Ackova ◽  
Tatjana Kanjevac ◽  
Lia Rimondini ◽  
Darko Bosnakovski
Keyword(s):  
Drug Delivery ◽  
Stromal Cells ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cancer Drug Delivery

scholarly journals Targeted Nano-Drug Delivery System to Colon Cancer

2021 ◽  
Author(s):  
Eskandar Moghimipour ◽  
Somayeh Handali
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Colon Cancer ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Delivery Systems ◽  
Cytotoxic Action ◽  
Promising Therapeutic Approach ◽  
Nano Drug Delivery ◽  
Anti Cancer

Cancer has been considered as the most cause of death in world. Employing of nanocarriers as drug delivery systems provide a platform for delivering drugs with increasing the anti-cancer efficacy, enhancing bioavailability of drugs, reducing side effects, enhancing the circulation half-life of drugs, improving the distribution of drugs and overcoming drug resistance. A number of nanocarriers have been studied as drug delivery systems for improving the treatment of cancer including liposomes, micelle, polymeric nanoparticles, carbon nanotubes, dendrimers, solid lipid nanoparticle (SLN) and nanostructure lipid carrier (NLC). In order to enhance recognition and internalization of nanocarriers by the target tissues, their surfaces can be modified with targeting ligands such as integrins, transferrin, folic acid, polysaccharides and antibodies. In this chapter, we are going to introduce the targeted nanocarriers for improving the cytotoxic action of drugs with further attempt of decreasing dose to achieve higher anticancer activity. Targeted nanocarriers would provide a promising therapeutic approach for cancer.

Ultrasound-Based Drug Delivery System

2021 ◽  
Vol 28 ◽  
Author(s):  
Wei-Wei Ren ◽  
Shi-Hao Xu ◽  
Li-Ping Sun ◽  
Kun Zhang
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Research Progress ◽  
Cancer Drugs ◽  
Nano Drug Delivery ◽  
Anti Cancer

: Cancer still represents a leading threat to human health worldwide. The effective usage of anti-cancer drugs can reduce patients’ clinical symptoms and extend the life span. Current anti-cancer strategies include chemotherapy, traditional Chinese medicine, biopharmaceuticals, and the latest targeted therapy. However, due to the complexity and heterogeneity of tumors, serious side effects may result from the direct use of anti-cancer drugs. Besides, the current therapeutic strategies failed to effectively alleviate metastasized tumors. Recently, an ultrasound-mediated nano-drug delivery system has become an increasingly important treatment strategy. Due to its ability to enhance efficacy and reduce toxic side effects, it has become a research hotspot in the field of biomedicine. In this review, we introduced the latest research progress of the ultrasound-responsive nano-drug delivery systems and the possible mechanisms of ultrasound acting on the carrier to change the structure or conformation as well as to realize the controlled release. In addition, the progress in ultrasound responsive nano-drug delivery systems will also be briefly summarized.

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