Antibiotic resistance patterns in medical and surgical patients in a combined medical-surgical intensive care unit

2013 ◽  
Vol 28 (4) ◽  
pp. 347-351 ◽  
Author(s):  
Jason A. Akulian ◽  
Mark L. Metersky
Keyword(s):  
Intensive Care Unit ◽  
Antibiotic Resistance ◽  
Intensive Care ◽  
Surgical Patients ◽  
Surgical Intensive Care Unit ◽  
Surgical Intensive Care ◽  
Resistance Patterns ◽  
Antibiotic Resistance Patterns

scholarly journals Bacterial profile and their antibiotic resistance patterns from blood culture in Intensive Care Unit patients at the University Of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

2019 ◽  
Author(s):  
Segen Tekle Gebre-egziabher ◽  
Feleke Moges Yehuala ◽  
Zemene Tigabu Kebede ◽  
Alem Getaneh Mehari
Keyword(s):  
Intensive Care Unit ◽  
Antibiotic Resistance ◽  
Intensive Care ◽  
Blood Culture ◽  
Bacterial Pathogens ◽  
Gram Negative ◽  
Specialized Hospital ◽  
Resistance Patterns ◽  
The University ◽  
Antibiotic Resistance Patterns

Abstract Abstract Background: The burden of bloodstream infection and antibiotic resistance in intensive care unit (ICU) is high when compared with other settings. The data on the changing antibiotic resistance trends are important for infection control activities. There is no sufficient data in the intensive care units of this hospital. Objective: The aims of this study were to assess the magnitude and risk factors of bacterial pathogens and their antibiotic resistance patterns of blood culture isolates from ICU patients at the University of Gondar Comprehensive Specialized Hospital, Gondar, Ethiopia. Materials and Methods: A cross-sectional study was conducted from February to May 2018.Blood specimen were collected from 384 patients and inoculated on appropriate culture media. Identification of bacterial pathogens and antibiotic susceptibility tests were performed using bacteriological standard methods. Presence of Extended Spectrum Beta Lactamase (ESBL) enzymes was confirmed by combined disk diffusion method. Data were analyzed using SPSS version 20. Result: Of the total 384 study participants, 96(25%) were culture positive. Majority of bacteria isolates 67(69.8%) were Gram negative. The commonly isolated bacterial species were K.pneumoniae 18(18.8%), Coagulase negative Staphylococcus 13(13.5%), K.ozanae 10(10.4%), K.rhinose 8(8.3%) and E.coli, E.cloacae, Citrobacter species, S.aureus each accounts 7(7.3%). Gram negative isolates were found to be resistant to ampicillin 66(98%), amoxicillin/clavulanate 64(95%) and ceftriaxone 52(77.6%). However, amikacin 64(95.5%), meropenem 58(87%) and Ciprofloxacin 56(83.6%) were relatively effective drugs. Gram positive isolates were found to be resistant to Penicillin 28(96.5%), amoxicillin/clavulanate27 (93.1%) and erythromycin 26(90%). They were sensitive to ciprofloxacin 22(79%) and clindamycin 24(83%). Methicillin resistant S.aureus accounted 4(57.1%) and ESBL enzyme producing Gram negative isolates accounted 41(78.8%). Conclusion: Klebsiella species were the predominant bacterial isolates in ICU settings. Antibiotic resistance due to ESBL enzyme production is alarmingly high. This result might be a reflection of inappropriate use of antibiotics and poor infection prevention control practice in these settings. Key words: Antibiotic resistance, ICU, ESBL, Gondar Ethiopia.

Increased Healthcare-Associated Infections in a Surgical Intensive Care Unit Related to Boarding Non-Surgical Patients

2019 ◽  
Vol 20 (4) ◽  
pp. 332-337
Author(s):  
Edward K. Len ◽  
Ritesh Akkisetty ◽  
Sandia Royal ◽  
Maryanne Brooks ◽  
Susette Coyle ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Surgical Patients ◽  
Surgical Intensive Care Unit ◽  
Healthcare Associated Infections ◽  
Surgical Intensive Care ◽  
Healthcare Associated

scholarly journals Impact of an Evidence-Based Antibiotic Protocol on Common Gram-Negative Bacteria's Antibiotic Resistance in a Cardiac Surgical Intensive Care Unit

2021 ◽  
Vol 05 (01) ◽  
pp. 012-017
Author(s):  
Sarvesh Pal Singh ◽  
Seshagiribabu Yagani ◽  
Shamsiya TP ◽  
Shivam Pandey ◽  
Manoj Kumar Sahu ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Antibiotic Resistance ◽  
Intensive Care ◽  
Antibiotic Sensitivity ◽  
Surgical Intensive Care Unit ◽  
Evidence Based ◽  
Gram Negative Bacteria ◽  
Surgical Intensive Care ◽  
Gram Negative ◽  
The Impact

Abstract Background Based on the analysis of infections and antibiotic usage in the years 2013 and 2014, an evidence-based antibiotic protocol was developed and implemented in our cardiac surgical intensive care unit (CSICU). This study intends to study the impact of this new protocol on the sensitivity profiles of common gram-negative bacteria in our CSICU. Methods The medical records of patients who underwent cardiac surgery at our center, between January 2017 and December 2018, were reviewed and the incidence of different hospital-acquired bacteria and their antibiotic sensitivity profiles were recorded. The antibiotic-sensitivity profiles of common gram-negative bacteria, for the years 2017 and 2018, were compared with the published data of 2013 and 2014 from our department. Results There was a significant decrease in the incidence of Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa resistant to carbapenems during 2017 and 2018. The incidence of colistin-resistant A. baumannii and P. aeruginosa also decreased significantly in 2017 and 2018. A significant increase in the proportion of amikacin resistant A. baumannii and E. coli and A. baumannii resistant to B lactam/B lactamase inhibitors also occurred. Conclusion Antibiotic stewardship can reverse the antibiotic resistance of common gram-negative bacteria in the ICU.

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