scholarly journals Quadrimodal distribution of death after trauma suggests that critical injury is a potentially terminal disease

2015 ◽  
Vol 30 (3) ◽  
pp. 656.e1-656.e7 ◽  
Author(s):  
Heena P. Santry ◽  
Charles M. Psoinos ◽  
Christopher J. Wilbert ◽  
Julie M. Flahive ◽  
Aimee R. Kroll-Desrosiers ◽  
...  
2019 ◽  
Vol 14 (5) ◽  
pp. 428-436 ◽  
Author(s):  
Gabriele D. Bigoni-Ordóñez ◽  
Daniel Czarnowski ◽  
Tyler Parsons ◽  
Gerard J. Madlambayan ◽  
Luis G. Villa-Diaz

Cancer is a highly prevalent and potentially terminal disease that affects millions of individuals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumorigenic characteristics and collect evidence demonstrating the importance of integrin α6 (ITGA6, also known as CD49f) in cancer stem cell (CSC) activity. ITGA6 is commonly used to identify CSC populations in various tissues and plays an important role sustaining the self-renewal of CSCs by interconnecting them with the tumorigenic microenvironment.


1997 ◽  
Vol 23 (1) ◽  
pp. 7-43
Author(s):  
Wendy E. Parmet ◽  
Daniel J. Jackson

The second social construction of HIV disease has begun. In the first fifteen years of the HIV epidemic, many viewed the disease “as the modern plague.” Now, as the epidemic matures and new “miracle treatments" are heralded, the disease is beginning to conjure a very different set of images. Where once AIDS was dreaded as the inexplicable cataclysm of the end of the millennium, now, as the virus appears amenable to treatment, we are beginning to see the disease as something both preventable and controllable, no longer beyond human direction. And, where the disease was once synonymous with death, disability, and decline, we now witness stories of miracle recoveries and long-term survival. In the minds of many, the terminal disease has become the chronic disease; the dreaded plague has become but another social problem.In most respects, the new social construction of HIV, emerging from the advent of potentially effective medical interventions, is a positive development.


2003 ◽  
Vol 84 (3) ◽  
pp. 377-384 ◽  
Author(s):  
Ida Roldán

As of June 2001, it was estimated that 22,000 people were living with AIDS in Chicago (CDC, 2001b), and 15% of these were Hispanic, of which 39% were Puerto Rican (Chicago Department of Health, 2000b). Although in recent years Chicago has seen a drop in HIV/AIDS-related deaths, HIV/AIDS is still devastating many Puerto Rican families. Many of those infected face the challenges of living with a chronic terminal disease, feeling alone and rejected by family and community. This research article summarizes the results of a qualitative study that explores the unique meanings that the Puerto Rican culture assigns to AIDS. The primary objective of this study was to capture the experience that is unique to the Puerto Rican family when a member has HIV/AIDS.


1993 ◽  
Vol 9 (6) ◽  
pp. 339-342 ◽  
Author(s):  
G. Lanzi ◽  
U. Balottin ◽  
R. Borgatti ◽  
A. Ottolini
Keyword(s):  

1998 ◽  
Vol 7 (5) ◽  
pp. 383-392 ◽  
Author(s):  
JS Leske ◽  
MK Jiricka

BACKGROUND: Increases in demands on patients' family members that are not reduced by family strengths may contribute to decreases in family adaptation and complicate patients' recovery after trauma. The purpose of this study was to examine family demands (prior stressors and severity of patients' injuries) and family strengths and capabilities (hardiness, resources, coping, and problem-solving communication) associated with outcomes of family well-being and adaptation. METHODS: A multivariate, descriptive design based on the Resiliency Model of Family Stress was used. A convenience sample of family members (N = 51) of adult patients participated within the first 2 days of critical injury. Family demands were measured with the Family Inventory of Life Events and Changes and the Acute Physiology, Age, and Chronic Health Evaluation III. Family strengths were measured with the Family Hardiness Index, Family Inventory of Resources for Management, Family Crisis Oriented Personal Evaluation Scale, and Family Problem Solving Communication Index. Family adaptation outcomes were measured with the Family Well Being Index and Family Adaptation Scale. RESULTS: Increases in family demands were significantly related to decreases in family strengths and family adaptation. Family demands scores accounted for 40% of the variance in family well-being scores. The only significant family strength variable influencing family adaptation was problem-solving communication. CONCLUSIONS: Increases in family demands seem to be an important indicator of the amount of assistance a family may need. Interventions that help mobilize family strengths, such as problem-solving communication, may be effective in promoting the adaptation of families of critically injured patients.


Injury ◽  
2020 ◽  
Vol 51 (5) ◽  
pp. 1203-1209
Author(s):  
Kim Foster ◽  
Connie Van ◽  
Andrea McCloughen ◽  
Rebecca Mitchell ◽  
Alexandra Young ◽  
...  

2001 ◽  
Vol 15 (3) ◽  
pp. 243-246 ◽  
Author(s):  
Giovambattista Zeppetella ◽  
Catherine A O'Doherty ◽  
Silke Collins

2015 ◽  
Vol 21 (Suppl 1) ◽  
pp. A3.3-A4
Author(s):  
Amy Peeples ◽  
Lindsey Myers ◽  
Shannon Breitzman ◽  
Tomi St. Mars

JAMA ◽  
1975 ◽  
Vol 232 (11) ◽  
pp. 1127c-1127
Author(s):  
S. A. Lack
Keyword(s):  

2020 ◽  
Vol 30 (7) ◽  
pp. 1033-1044
Author(s):  
Alexis M. Fabricius ◽  
Andrea D’Souza ◽  
Vanessa Amodio ◽  
Angela Colantonio ◽  
Tatyana Mollayeva

Despite recognizing that women have worse outcomes after traumatic brain injury (TBI), little is known about how gender influences their experiences of this critical injury. Past research has been dominated by androcentrism and quantitative approaches, leaving the lived experience of women with TBI insufficiently examined. To gain insight into their experiences, this qualitative study interviewed 19 Canadian women with mild and moderate-to-severe TBIs. Applying a thematic analysis, we discerned three themes: Gender prevails considers choosing to do gender over complying with physician advice; Consequences of TBI impeding performativity explores how women frame themselves as terrible people for being unable to do gender post-TBI; and Perceptions of receiving care looks at gendered caregiving expectations. These results broadly align with research on how doing gender influences recovery and health outcomes. We discuss the implications of our findings for knowledge translation, future research on women’s TBI recovery, and clinical practice.


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