scholarly journals Closed loop bioreactor system for the ex vivo expansion of human T cells

Cytotherapy ◽  
2019 ◽  
Vol 21 (1) ◽  
pp. 76-82
Author(s):  
MATTHEW LI ◽  
LING-YEE CHIN ◽  
SYUKRI SHUKOR ◽  
ALFRED TAMAYO ◽  
MARCELA V. MAUS ◽  
...  
2015 ◽  
Vol 4 (1) ◽  
pp. e31 ◽  
Author(s):  
Corey Smith ◽  
Grethe Økern ◽  
Sweera Rehan ◽  
Leone Beagley ◽  
Sau K Lee ◽  
...  

2005 ◽  
Vol 175 (6) ◽  
pp. 3656-3662 ◽  
Author(s):  
María-Eugenia Miranda-Carús ◽  
Marta Benito-Miguel ◽  
Miguel A. Llamas ◽  
Alejandro Balsa ◽  
Emilio Martín-Mola

2021 ◽  
Vol 12 ◽  
Author(s):  
Mia Levite

T cells are essential for eradicating microorganisms and cancer and for tissue repair, have a pro-cognitive role in the brain, and limit Central Nervous System (CNS) inflammation and damage upon injury and infection. However, in aging, chronic infections, acute SARS-CoV-2 infection, cancer, chronic stress, depression and major injury/trauma, T cells are often scarce, exhausted, senescent, impaired/biased and dysfunctional. People with impaired/dysfunctional T cells are at high risk of infections, cancer, other diseases, and eventually mortality, and become multi-level burden on other people, organizations and societies. It is suggested that “Nerve-Driven Immunity” and “Personalized Adoptive Neuro-Immunotherapy” may overcome this problem. Natural Neurotransmitters and Neuropeptides: Glutamate, Dopamine, GnRH-II, CGRP, Neuropeptide Y, Somatostatin and others, bind their well-characterized receptors expressed on the cell surface of naïve/resting T cells and induce multiple direct, beneficial, and therapeutically relevant effects. These Neurotransmitters and Neuropeptides can induce/increase: gene expression, cytokine secretion, integrin-mediated adhesion, chemotactic migration, extravasation, proliferation, and killing of cancer. Moreover, we recently found that some of these Neurotransmitters and Neuropeptides also induce rapid and profound decrease of PD-1 in human T cells. By inducing these beneficial effects in naïve/resting T cells at different times after binding their receptors (i.e. NOT by single effect/mechanism/pathway), these Neurotransmitters and Neuropeptides by themselves can activate, rejuvenate, and improve T cells. “Personalized Adaptive Neuro-Immunotherapy” is a novel method for rejuvenating and improving T cells safely and potently by Neurotransmitters and Neuropeptides, consisting of personalized diagnostic and therapeutic protocols. The patient’s scarce and/or dysfunctional T cells are activated ex vivo once by pre-selected Neurotransmitters and/or Neuropeptides, tested, and re-inoculated to the patient’s body. Neuro-Immunotherapy can be actionable and repeated whenever needed, and allows other treatments. This adoptive Neuro-Immunotherapy calls for testing its safety and efficacy in clinical trials.


1999 ◽  
Vol 8 (2) ◽  
pp. 129-139 ◽  
Author(s):  
Danna Skea ◽  
Nan-Hua Chang ◽  
Robin Hedge ◽  
Barbara Dabek ◽  
Truman Wong ◽  
...  

Apmis ◽  
2019 ◽  
Vol 127 (12) ◽  
pp. 737-745 ◽  
Author(s):  
Sasan Ghaffari ◽  
Monireh Torabi‐Rahvar ◽  
Azadeh Omidkhoda ◽  
Naser Ahmadbeigi

2018 ◽  
Vol 36 (2) ◽  
pp. 160-169 ◽  
Author(s):  
Alexander S Cheung ◽  
David K Y Zhang ◽  
Sandeep T Koshy ◽  
David J Mooney

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