Combining acetyl salicylic acid and rofecoxib into novel oral tablets normalize platelet function with potential higher tolerability in patients with cardiovascular disorders

2020 ◽  
Vol 59 ◽  
pp. 101851
Author(s):  
Mahmoud A. Younis ◽  
Helal F. Hetta ◽  
Mohamed A.Y. Abdel-Malek ◽  
Hassan Refat H. Ali ◽  
Noha N. Atia ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Platelet Function ◽  
Acetyl Salicylic Acid ◽  
Cardiovascular Disorders

Antiplatelet Drugs, Controlled by Platelet Survival

1979 ◽  
Author(s):  
G. Bremer ◽  
O. Richter ◽  
E. Jacobi
Keyword(s):  
Diabetes Mellitus ◽  
Salicylic Acid ◽  
Platelet Function ◽  
Acetyl Salicylic Acid ◽  
Antiplatelet Drugs ◽  
Secondary Complications ◽  
Platelet Survival ◽  
The Mean

The mean Platelet survival is an in-vivo parameter in the analysis of platelet function. Thromboembolic diseases are associated with shortened platelet survival, because platelets are consumed in the thrombus generanation. Platelet survival therefore is an parameter for controlling the effectiveness of antiplatelet drugs. In order to investigate the effect of several antiplatelet drugs, platelet survival is measured in Patients suffered from long-standing diabetes mellitus with secondary complications with and without the following antiplatelet drugs: 3 times of 500 mg per day SH 1117 (Sulfinylaceticacidemethylester), 3 times of R 149 per day (75 mg Dipyridamole + 330 mg Acetyl-Salicylic-Acid) and a third group treated with 3 times per day 150 mg Anturano + 150 mg Dipyridamole. The shortened platelet survival in Diabetes mellitus can be normalized by R 149, whilest SH 1117 increases the platelet survival only moderately. Under the treatment with Anturano combined with Dipyridamole platelet survival is prolonged, but not normalized.

The Combined Effect of Dipyridamole and Acetyl Salicylic Acid on Platelet Function and Bleeding Time : Evaluation of Dose for the Prophylaxis of Thrombosis

1979 ◽  
Author(s):  
A.F. Penny ◽  
M. J. Crow ◽  
S. M. Rajah ◽  
R.C. Kester
Keyword(s):  
Salicylic Acid ◽  
Platelet Function ◽  
Low Dose ◽  
Bleeding Time ◽  
Cumulative Effect ◽  
Acetyl Salicylic Acid ◽  
Additional Group ◽  
Dose Combination ◽  
Time Evaluation ◽  
Platelet Functions

The interaction of Dipyridamole (DPM) and Acetyl Salicylic Acid (ASA) on volunteers was investigated. ASA was given in single doses (multiples of 60mg) at 2 week intervals. DPM (multiples of 25 mg) was given tds for 2 days with a single dose of DPM and ASA on the morning of day 3. Bleeding time and platelet functions were performed 2 hours after each dose. ASA 300mg maximally inhibited aggregation, adhesion and PF4 release. Lower doses of ASA gave significant reductions in collagen aggregation at 120 mg, adhesion at 180mg and PF4 at 240mg. DPM 25mg tds produced reductions in collagen aggregation, adhesion and PF4. Maximal inhibition of platelet function without alteration in bleeding time was achieved by 50mg tds DPM + 180mg ASA or 75mg tds DPM + 120mg ASA. Bleeding time was normal with ASA 120mg, 180mg; prolonged at 300mg and 1000mg and tending to be normalised by 2g. Addition of DPM 75mg tds at each dose of ASA made no alteration in bleeding time. There was a cumulative effect of ASA on bleeding time. Combined DPM mg tds and low dose ASA present a balanced anti thrombotic regimen probably both inactivating thromboxane A2 production and enhancing prostacyclin activity. This dose combination is worthy of evaluation as an additional group, in trials.

Template bleeding time after ingestion of ultra low dosages of acetyl salicylic acid in healthy subjects. Preliminary study

1987 ◽  
Vol 48 (4) ◽  
pp. 501-504 ◽  
Author(s):  
C. Doutremepuich ◽  
D. Pailley ◽  
M.C. Anne ◽  
O. de Séze ◽  
J. Paccalin ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Healthy Subjects ◽  
Bleeding Time ◽  
Acetyl Salicylic Acid ◽  
Preliminary Study

Acetyl salicylic acid alleviates chilling-induced damage in muskmelon seedlings

2007 ◽  
Vol 87 (3) ◽  
pp. 581-585 ◽  
Author(s):  
Ahmet Korkmaz ◽  
Murat Uzunlu ◽  
Ali Riza Demirkiran
Keyword(s):  
Salicylic Acid ◽  
Cucumis Melo ◽  
Chilling Stress ◽  
Foliar Spray ◽  
Dry Weight ◽  
Acetyl Salicylic Acid ◽  
Signal Molecule ◽  
Stress Indicator ◽  
Shoot Dry Weight ◽  
Significant Difference

Salicylic acid (SA) is a common plant-produced signal molecule that is responsible for inducing tolerance to a number of biotic and abiotic stresses. An experiment was, therefore, conducted to test whether acetyl salicylic acid (ASA) application at various concentrations through seed immersion or foliar spray would protect muskmelon [Cucumis melo L. (Reticulatus Group)] seedlings subjected to chilling stress. Twenty-one-day-old plants pre-treated with ASA (0, 0.1, 0.25, 0.50 or 1.0 mM) were subjected to chilling stress for 72 h at 3 ± 0.5°C. ASA, applied either through seed immersion or foliar spray, was effective within the range of 0.1 to 1 mM in inducing tolerance to chilling stress in muskmelon seedlings; however, there was no significant difference between application methods. ASA significantly and curvilinearly affected all seedling growth and stress indicator variables tested except shoot dry weight. The best protection was obtained from seedlings pre-treated with 0.5 mM ASA. The highest ASA concentration used was slightly less effective in providing chilling stress protection. Even though both methods provided similar means of protection, due to its simplicity and practicality, immersion of muskmelon seeds prior to sowing in 0.5 mM ASA would be a more desirable method to induce tolerance to chilling stress. Key words: Cucumis melo, aspirin, chilling stress tolerance, gas exchange, electrolyte leakage

Control of post-harvest anthracnose infection in guava (Psidium guajava) fruits with phosphites, calcium chloride, acetyl salicylic acid, hot water, and 1-MCP

2015 ◽  
Vol 56 (3) ◽  
pp. 330-340 ◽  
Author(s):  
André Freire Cruz ◽  
Nathalia Lima Medeiros ◽  
Gustavo Lessa Benedet ◽  
Maira Borges Araújo ◽  
Carlos Hidemi Uesugi ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Calcium Chloride ◽  
Psidium Guajava ◽  
Hot Water ◽  
Acetyl Salicylic Acid ◽  
Post Harvest
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