scholarly journals Large auto-hemoinfusion versus rectal insufflation in patients with metabolic syndrome

Ozone Therapy ◽  
2016 ◽  
Vol 1 (1) ◽  
pp. 13
Author(s):  
Francesco Vaiano ◽  
Fortunato Loprete
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Clinical Situation ◽  
Gas Mixture ◽  
High Cardiovascular Risk ◽  
Factors Associated ◽  
The Metabolic Syndrome ◽  
Alternative Method

The metabolic syndrome is a clinical situation including a series of factors at high cardiovascular risk; the treatment with an oxygenozone gas mixture can influence all factors associated with this syndrome. The objective of the study has been to verify if the rectal insufflation could replace the large auto-hemoinfusion when treating the metabolic syndrome in those patients who, for various reasons cannot use the auto-hemoinfusion. Twenty-four individuals aged between 34 and 68 were recruited and included in the group treated with ozonated auto-hemoinfusion and other 24 individuals aged between 35 and 67 were recruited and included in the group treated with rectal insufflation of the oxygen-ozone gas mixture. According to the results obtained by means of oxygen-ozone mixture rectal insufflation, which are almost equivalent to the results obtained with the large ozonated auto-hemoinfusion, authors could conclude that the ozonated rectal insufflation can be taken into consideration as alternative method to the large auto-hemoinfusion, while treating the metabolic syndrome, in those patients difficult to manage due to the previously described reasons.

scholarly journals Acarbose therapy as prevention of multiple cardiovascular risk factors of metabolic syndrome

2003 ◽  
Vol 9 (2) ◽  
pp. 51-54 ◽  
Author(s):  
V. B. Mychka ◽  
R. M. Bogiyeva ◽  
K. M. Mamyrbayeva ◽  
I. Ye. Chazova
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Glycated Hemoglobin ◽  
Postprandial Glucose ◽  
High Cardiovascular Risk ◽  
Adequate Treatment ◽  
Death Rates ◽  
Glucose Levels ◽  
The Metabolic Syndrome

The metabolic syndrome is a state that precedes the development of atherosclerosis, type 2 diabetes mellitus, and arterial hypertension (AH) Timely adequate treatment may prevent the development and progression of these diseases that are main causes of higher death rates Peripheral acting drugs should be preferred for patients at high cardiovascular risk Acarbose is one of these drugs It prevents carbohydrates from being absorbed in the small bowel The results of our use of acarbose have shown its high efficacy Acarbose therapy significantly decreases body weight, postprandial glucose levels, glycated hemoglobin, and blood pressure Acarbose may be used as monotherapy in patients with the metabolic syndrome and mild AH

Abstract 1124: CD40L Induces Inflammation in Adipose Tissue - a Potential Link Between the Metabolic Syndrome and Atherosclerosis

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Anna Missiou ◽  
Isabel Platzer ◽  
Sandra Ernst ◽  
Uwe Schonbeck ◽  
Peter Libby ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Endothelial Cells ◽  
Adipose Tissue ◽  
Cardiovascular Risk ◽  
Inflammatory Cytokine ◽  
Inflammatory Responses ◽  
Human Adipose Tissue ◽  
Cell Types ◽  
High Cardiovascular Risk ◽  
The Metabolic Syndrome

Background: CD40L figures prominently as marker and mediator of atherosclerosis and its clinical complications. Recent data also demonstrate an association between CD40L and the metabolic syndrome. In the light of these data we hypothesized a functional pro-inflammatory role of CD40L in adipose tissue that provokes systemic pro-inflammatory responses and potentially mediates some of the high cardiovascular risk associated with the metabolic syndrome. Methods and Results: Adipocytes and preadipocytes isolated from adipose tissue obtained from bariatic surgery did not express CD40L but its receptor CD40 as assessed by PCR and immunohistochemistry. Furthermore, sections of human adipose tissue from obese donors contained more macrophages and T cells colocalizing with CD40L than those from lean controls. Stimulation of both adipocytes and preadipocytes with recombinant CD40L resulted in a concentration- and time-dependent release of the pro-inflammatory cytokine IL-6, the chemokines MCP -1 and IL-8 as well as the inhibitor of fibrinolysis PAI-1 into the supernatant as quantified by ELISA. Membranes isolated from a Murine cell line overexpressing human CD40L reproduced these pro-inflammatory effects compared to respective controls. Interestingly, fenofibrate but neither rosiglitazone, metformin, nor atorvastatin attenuated the CD40L-inducible expression of these pro-atherogenic mediators. Finally, supernatants from adipocytes and preadipocytes stimulated with CD40L activated endothelial cells and macrophages, typical cell types resident in atherosclerotic lesions, as assessed by FACS for tissue factor, Mac-1, and ICAM-1, respectively. Conclusions: Our data suggest that CD40L induces inflammatory cytokine production in adipose tissue resulting in activation of endothelial cells and macrophages. This new mechanism may contribute to the high cardiovascular risk of patients suffering from the metabolic syndrome.

scholarly journals Salud electrónica para el autocuidado de pacientes con factores de riesgo asociados al síndrome metabólico

2016 ◽  
Vol 18 (1) ◽  
pp. 170 ◽  
Author(s):  
Consuelo Vélez Álvarez ◽  
José Armando Vidarte Claros ◽  
Rosa Elvira Álvarez Rosero ◽  
Jully Andrea García Navarro
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Overweight And Obesity ◽  
World Health ◽  
Factors Associated ◽  
The Metabolic Syndrome ◽  
Síndrome Metabólico ◽  
Factores De Riesgo

ResumenEl propósito de esta revisión, es identificar la evidencia científica sobre el uso de estrategias de salud electrónica en las intervenciones dirigidas a mejorar el autocuidado de pacientes con factores de riesgo cardiovascular asociado con la presencia de síndrome metabólico. Los artículos analizados fueron identificados en las bases de datos PubMed, Science Direct, Embase, Elsevier, Scielo, Adicional a esto se revisaron publicaciones estadísticas de la Organización Mundial de la Salud, La Federación Internacional de Diabetes, Guía de Síndrome Metabólico 2009 y ICT Facts and Figures World in 2013. Se tuvieron en cuenta 51 publicaciones realizadas entre los años 2009 y 2015, encontrándose mayor información en la intervención basada en el control del sobrepeso y la obesidad, como principal factor de riesgo para el desarrollo del síndrome metabólico. La evidencia encontrada en la literatura científica muestra la utilidad de la salud electrónica en el manejo de los factores de riesgo cardiovasculares asociados al síndrome metabólico, y el impacto de esta en la calidad de vida cuando son aplicadas con un adecuado protocolo.  AbstractThe purpose of this review is to identify the scientific evidence on the use of electronic health strategies in interventions aimed at improving self-care of patients with cardiovascular risk factors associated with the presence of metabolic syndrome. The articles analyzed were identified in the databases PubMed, Science Direct, Embase, Elsevier and Scielo. In addition, statistical publications from the World Health Organization, the International Diabetes Federation, Metabolic Syndrome Guide 2009 and ICT Facts and Figures World in 2013 were reviewed. 51 publications between the years 2009 and 2015 were considered, where there were more information about the intervention based on the control of overweight and obesity as a major risk factor for the development of the metabolic syndrome. The evidence found in the scientific literature shows the usefulness of e-health in the management of cardiovascular risk factors associated with metabolic syndrome, and its impact on the quality of life when they are applied with a suitable protocol.

scholarly journals Moderate red wine consumption is associated with a lower prevalence of the metabolic syndrome in the PREDIMED population

2015 ◽  
Vol 113 (S2) ◽  
pp. S121-S130 ◽  
Author(s):  
Anna Tresserra-Rimbau ◽  
Alexander Medina-Remón ◽  
Rosa M. Lamuela-Raventós ◽  
Monica Bulló ◽  
Jordi Salas-Salvadó ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Red Wine ◽  
Multiple Logistic Regression Analysis ◽  
Incidence Rates ◽  
Mediterranean Population ◽  
Lower Prevalence ◽  
High Cardiovascular Risk ◽  
Cross Sectional ◽  
The Metabolic Syndrome

Previous studies on the association between alcohol intake and the development of the metabolic syndrome (MetS) have yielded inconsistent results. Besides, few studies have analysed the effects of red wine (RW) consumption on the prevalence of the MetS and its components. As moderate RW drinkers have a better lipid profile and lower incidence rates of diabetes, hypertension and abdominal obesity, all components of the MetS, it was hypothesised that moderate RW consumption could be associated with a lower prevalence of the MetS. In the present cross-sectional study of 5801 elderly participants at a high cardiovascular risk included in the PREDIMED (Prevención con Dieta Mediterránea) study, 3897 fulfilled the criteria of the MetS at baseline. RW intake was recorded using a validated 137-item FFQ. Multiple logistic regression analysis was carried out to estimate the association between RW intake and the prevalence of the MetS. Compared with non-drinkers, moderate RW drinkers ( ≥ 1 drink/d) were found to have a reduced risk of prevalent MetS (OR 0·56, 95 % CI 0·45, 0·68;P< 0·001), a lower risk of having an abnormal waist circumference (OR 0·59, 95 % CI 0·46, 0·77;P< 0·001), low HDL-cholesterol concentrations (OR 0·42, 95 % CI 0·32, 0·53;P< 0·001), high blood pressure (OR 0·28, 95 % CI 0·17, 0·45;P< 0·001) and high fasting plasma glucose concentrations (OR 0·67, 95 % CI 0·54, 0·82;P< 0·001) after adjusting for several confounders. This association was found to be stronger in female participants, in participants aged < 70 years and in participants who were former or current smokers. No significant association was found between RW intake ( ≥ 1 drink/d) and TAG concentrations. In conclusion, moderate RW consumption is associated with a lower prevalence of the MetS in an elderly Mediterranean population at a high cardiovascular risk.

Cardiovascular Risk Assessement in Osteoporotic Patients Using Osteoprotegerin as a Reliable Predictive Biochemical Marker

2018 ◽  
pp. 253
Author(s):  
Noora Wael Rasheed ◽  
Ooroba Jameel Taresh
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Serum Level ◽  
Biochemical Markers ◽  
Hdl Cholesterol ◽  
Predictive Marker ◽  
Serum Levels ◽  
Arterial Calcification ◽  
The Metabolic Syndrome

       Some studies indicated a relationship between increased serum levels of osteoprotegerin with arterial calcification and as a result, it leads to the risk of cardiovascular disease. In our study group we selected patients with osteoporosis, with similar age and body mass index for the assessment of the relationship between cardiovascular disease and osteoprotegerin serum level. We took into account the analysis of correlation and association between the presence of distinct patterns of atherosclerosis and associated diseases like high blood pressure,  diabetes mellitus, low HDL cholesterol, increased LDL cholesterol, increased triglycerides and was the case of presence of any type of dyslipidemia, in case of pre-existent treatment. Objective of study was the assessment of osteoprotegerin value as predictive marker for cardiovascular and metabolic risk in osteoporotic patients. Our results showed significant correlations of parathyroid hormone, osteocalcin and biochemical markers of bone with glucose metabolism and lipid were found in our research, maintaining crosstalk between calcium and biochemical markers of bone and cardiovascular risk. The serum level of Osteoprotegerin has been shown to have a large predictive value for the metabolic syndrome as a cardiovascular risk standard in patients with osteoporosis. The osteoprotegerin serum levels were increased in the patients with metabolic syndrome as a protective response facing the atherosclerotic lesions.

Risk Factors for Cardiovascular Disease in Patients Undergoing Peritoneal Dialysis

2007 ◽  
Vol 27 (2_suppl) ◽  
pp. 205-209 ◽  
Author(s):  
Elvia García–López ◽  
Juan J. Carrero ◽  
Mohamed E. Suliman ◽  
Bengt Lindholm ◽  
Peter Stenvinkel
Keyword(s):  
Risk Factors ◽  
Peritoneal Dialysis ◽  
Cardiovascular Risk ◽  
Pressure Control ◽  
High Cardiovascular Risk ◽  
Cardiovascular Research ◽  
Factors Associated ◽  
Glycation End Products ◽  
Anemia Management ◽  
Altered Lipid

Patients on peritoneal dialysis (PD) are at high cardiovascular risk. Although some risk factors are unmodifiable (for example, age, sex, genetics), others are exacerbated in the unfriendly uremic milieu (inflammation, oxidative stress, mineral disturbances) or contribute per se to kidney disease and cardiovascular progression (diabetes mellitus, hypertension). Moreover, several factors associated with PD therapy may both increase (by altered lipid profile, hyperinsulinemia, and formation of advanced glycation end-products) and decrease (by better blood pressure control and anemia management) cardiovascular risk. The present review discusses recent findings and therapy trends in cardiovascular research on the PD population, with emphasis on the roles of inflammation, insulin resistance, homocysteinemia, dyslipidemia, vascular calcification, and genetics/epigenetics.

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