scholarly journals Red algae ( Gelidium amansii ) hot-water extract ameliorates lipid metabolism in hamsters fed a high-fat diet

2017 ◽  
Vol 25 (4) ◽  
pp. 931-938 ◽  
Author(s):  
Tsung-Han Yang ◽  
Hsien-Tsung Yao ◽  
Meng-Tsan Chiang
Keyword(s):  
Lipid Metabolism ◽  
Red Algae ◽  
High Fat Diet ◽  
Water Extract ◽  
Hot Water ◽  
High Fat ◽  
Gelidium Amansii ◽  
Hot Water Extract

scholarly journals Polygonum multiflorum Thunb. Hot Water Extract Reverses High-Fat Diet-Induced Lipid Metabolism of White and Brown Adipose Tissues in Obese Mice

Plants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1509
Author(s):  
Ra-Yeong Choi ◽  
Mi-Kyung Lee
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
High Fat Diet ◽  
Water Extract ◽  
Hot Water ◽  
Obese Mice ◽  
High Fat ◽  
Polygonum Multiflorum ◽  
Hot Water Extract ◽  
Brown Adipose

The purpose of the present study was to determine whether an anti-obesity effect of a Polygonum multiflorum Thunb. hot water extract (PW) was involved in the lipid metabolism of white adipose tissue (WAT) and brown adipose tissue (BAT) in high-fat diet (HFD)-induced C57BL/6N obese mice. Mice freely received a normal diet (NCD) or an HFD for 12 weeks; HFD-fed mice were orally given PW (100 or 300 mg/kg) or garcinia cambogia (GC, 200 mg/kg) once a day. After 12 weeks, PW (300 mg/kg) or GC significantly alleviated adiposity by reducing body weight, WAT weights, and food efficiency ratio. PW (300 mg/kg) improved hyperinsulinemia and enhanced insulin sensitivity. In addition, PW (300 mg/kg) significantly down-regulated expression of carbohydrate-responsive element-binding protein (ChREBP) and diacylglycerol O-acyltransferase 2 (DGAT2) genes in WAT compared with the untreated HFD group. HFD increased BAT gene levels such as adrenoceptor beta 3 (ADRB3), peroxisome proliferator-activated receptor γ (PPARγ), hormone-sensitive lipase (HSL), cluster of differentiation 36 (CD36), fatty acid-binding protein 4 (FABP4), PPARγ coactivator 1-α (PGC-1α), PPARα, and carnitine palmitoyltransferase 1B (CPT1B) compared with the NCD group; however, PW or GC effectively reversed those levels. These findings suggest that the anti-obesity activity of PW was mediated via suppression of lipogenesis in WAT, leading to the normalization of lipid metabolism in BAT.

scholarly journals The Anti-Obesity Effect of Polysaccharide-Rich Red Algae (Gelidium amansii) Hot-Water Extracts in High-Fat Diet-Induced Obese Hamsters

Marine Drugs ◽  
2019 ◽  
Vol 17 (9) ◽  
pp. 532
Author(s):  
Yang ◽  
Chiu ◽  
Lu ◽  
Liu ◽  
Chiang
Keyword(s):  
Red Algae ◽  
Guar Gum ◽  
Uncoupling Protein ◽  
Water Extract ◽  
Diet Group ◽  
Water Soluble ◽  
Hot Water ◽  
Peroxisome Proliferator ◽  
High Fat ◽  
Gelidium Amansii

This study investigated the anti-obesity effect of a polysaccharide-rich red algae Gelidium amansii hot-water extract (GHE) in high-fat (HF) diet-induced obese hamsters. GHE contained 68.54% water-soluble indigestible carbohydrate polymers. Hamsters were fed with a HF diet for 5 weeks to induce obesity, and then randomly divided into: HF group, HF with 3% guar gum diet group, HF with 3% GHE diet group, and HF with orlistat (200 mg/kg diet) group for 9 weeks. The increased weights of body, liver, and adipose in the HF group were significantly reversed by GHE supplementation. Lower plasma leptin, tumor necrosis factor-α, and interleukin-6 levels were observed in the GHE+HF group compared to the HF group. GHE also increased the lipolysis rate and decreased the lipoprotein lipase activity in adipose tissues. GHE induced an increase in the phosphorylation of AMP-activated protein kinase (AMPK) and the protein expressions of peroxisome proliferator-activated receptor alpha (PPARα) and uncoupling protein (UCP)-2 in the livers. The decreased triglyceride and total cholesterol in the plasma and liver were also observed in obese hamsters fed a diet with GHE. These results suggest that GHE exerts a down-regulation effect on hepatic lipid metabolism through AMPK phosphorylation and up-regulation of PPARα and UCP-2 in HF-induced obese hamsters.

scholarly journals Hot Water Extract of Mulberry Leaf Ameliorates Hepatic Fat Accumulation and Inflammation in Rats Fed a High-Fat Diet

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 415-415
Author(s):  
Jibin Kim ◽  
Chaemin Kim ◽  
Mak-Soon Lee ◽  
Hyunmi Ko ◽  
Soojin Lee ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Water Extract ◽  
Density Lipoprotein ◽  
Hot Water ◽  
Mrna Levels ◽  
High Fat ◽  
Fat Accumulation ◽  
Mulberry Leaf ◽  
Hot Water Extract ◽  
Hepatic Fat

Abstract Objectives This study was conducted to investigate the effect of mulberry leaf extract on hepatic fat accumulation and inflammation in rats fed a high-fat diet. Methods Male Sprague–Dawley rats were randomly divided into three groups. Each group fed normal diet (NOR), high-fat diet (HF), or HF supplemented with 0.8% (w/w) hot water extract of mulberry leaf (HF + ME) for 14 weeks. Results The mulberry extract (ME) supplementation reduced body weight and white adipose tissues (epididymal, retroperitoneal, and mesenteric) weights. Serum levels of triglyceride (TG), total cholesterol (TC), free fatty acids (FFAs), and low-density lipoprotein cholesterol (LDL-C) were lower, while high-density lipoprotein cholesterol (HDL-C) level was higher in the HF + ME group compared to the HF group. The ME reduced the hepatic total lipid, TG, and TC levels compared to the HF group. The mRNA levels of genes related to fatty acid synthesis, such as CD36, sterol regulatory element binding protein 1c (SREBP-1c), and fatty acid synthase (FAS) were down-regulated by the ME supplementation. In addition, the ME lowered the mRNA levels of pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), compared to the HF group. The serum TNF-α level of the HF + ME group was significantly lower than that of the HF group. Conclusions These results suggested that the ME attenuated high-fat diet-induced hepatic fat accumulation and inflammation via regulating gene expression related to hepatic lipid metabolism and pro-inflammatory mediators. Therefore, it is postulated that the ME might be useful as a functional food ingredient to prevent obesity-induced hepatic fat accumulation and inflammation. Funding Sources None.

Standardized hot water extract from the leaves of Hydrangea serrata (Thunb.) Ser. alleviates obesity via the AMPK pathway and modulation of the gut microbiota composition in high fat diet-induced obese mice

2021 ◽  
Author(s):  
Hee-Soo Han ◽  
Hwi-Ho Lee ◽  
Hyo-Sun Gil ◽  
Kyung-Sook Chung ◽  
Jeon-Kyung Kim ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Water Extract ◽  
Hot Water ◽  
Microbiota Composition ◽  
Obese Mice ◽  
Mtor Signaling Pathway ◽  
High Fat ◽  
Hot Water Extract ◽  
Gut Microbiota Composition

WHS prevented the HFD-induced obesity via regulating AMPK and AKT/mTOR signaling pathway. WHS might be a potential dietary supplement for alleviating obesity.

scholarly journals Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet

2010 ◽  
Vol 17 (Suppl 1) ◽  
pp. S39 ◽  
Author(s):  
Huan Du ◽  
Xu Zhao ◽  
Jeong-Soon You ◽  
Ji-Yeon Park ◽  
Sung-Hoon Kim ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Water Extract ◽  
Hot Water ◽  
Protective Effects ◽  
High Fat ◽  
Taurine Supplementation ◽  
Lotus Root ◽  
Hot Water Extract

scholarly journals Antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet

2010 ◽  
Vol 17 (Suppl 1) ◽  
pp. S42 ◽  
Author(s):  
Huan Du ◽  
Jeong-Soon You ◽  
Xu Zhao ◽  
Ji-Yeon Park ◽  
Sung-Hoon Kim ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Water Extract ◽  
Hot Water ◽  
High Fat ◽  
Taurine Supplementation ◽  
Lotus Leaf ◽  
Hot Water Extract

scholarly journals Anti-obesity effects of hot water extract from Wasabi (Wasabia japonica Matsum.) leaves in mice fed high-fat diets

2013 ◽  
Vol 7 (4) ◽  
pp. 267 ◽  
Author(s):  
Masayuki Yamasaki ◽  
Tetsuro Ogawa ◽  
Li Wang ◽  
Takuya Katsube ◽  
Yukikazu Yamasaki ◽  
...  
Keyword(s):  
Water Extract ◽  
Hot Water ◽  
High Fat ◽  
Wasabia Japonica ◽  
Hot Water Extract ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Camellia oleifera seed extract attenuated abdominal and hepatic fat accumulation in rats fed a high-fat diet

2019 ◽  
Vol 44 (3) ◽  
pp. 320-325 ◽  
Author(s):  
Hsin-Yi Yang ◽  
Wan-Ju Yeh ◽  
Jung Ko ◽  
Jiun-Rong Chen
Keyword(s):  
High Fat Diet ◽  
Control Diet ◽  
Water Extract ◽  
Liquid Diet ◽  
Hot Water ◽  
Liver Fat ◽  
Camellia Oleifera ◽  
High Fat ◽  
Fat Accumulation ◽  
Hepatic Fat

The objective of this study was to evaluate the effects of the hot-water extract of defatted Camellia oleifera seeds (CSE) on body and liver fat accumulation in rats. Forty rats were divided into 5 groups and each group was fed either an isocaloric control diet or a high-fat liquid diet with 0% (H), 0.12% (H1), 0.24% (H2), or 0.48% CSE (H3) for 8 weeks. Ingestion of the high-fat liquid diet increased abdominal and liver fat accumulation, although no difference was found in body weights compared with rats fed the control diet. We found that rats fed the H2 and H3 diets had lower plasma alanine aminotransferase activities than the H group in the fourth and eighth weeks. At the end of the study, the H2 and H3 groups also had lower epididymal and retroperitoneal fat masses, and all CSE groups had lower circulatory leptin levels than the H group. CSE consumption decreased hepatic fat accumulation in terms of liver triglycerides and a histopathology analysis, and ameliorated high-fat diet-induced elevation of hepatic tumor necrosis factor-α levels. We also found that CSE groups had lower malondialdehyde and hydroxyproline levels in the liver. Our results suggested that CSE may exert beneficial effects through decreasing body fat accumulation and hepatic steatosis and regulating adipokine levels in diet-induced nonalcoholic fatty liver disease.

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